Yazar "Ozercan, Ibrahim H." seçeneğine göre listele

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    (3R, 3'R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers
    (Taylor & Francis Ltd, 2019) Sahin, Kazim; Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Gencoglu, Hasan; Sahin, Nurhan; Ozercan, Ibrahim H.
    Purpose: Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan (R); OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation. Methods: Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Retinal morphology was analyzed by histopathology, and target gene expressions were detected with real-time polymerase chain reaction methods. Results: OMX treatment significantly increased the serum zeaxanthin concentration (p < 0.001) and ameliorated oxidative damage by increasing the antioxidant enzyme activities in the retina induced by light (p < 0.001). OMX administration significantly upregulated the expression of genes, including Rhodopsin (Rho), Rod arrestin (SAG), G alpha Transducin 1 (GNAT-1), neural cell adhesion molecule (NCAM), growth-associated protein 43 (GAP43), nuclear factor-(erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase (HO-1) and decreased the expression of nuclear factor-kappa B (NF- kappa B) and GFAP by OMX treatment rats. The histologic findings confirmed the antioxidant and gene expression data. Conclusions: This study suggests that OMX is a potent substance that can be used to protect photoreceptor cell degeneration in the retina exposed to intense light.
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    Effect of inositol -stabilized arginine silicate on arthritis in a rat model
    (Pergamon-Elsevier Science Ltd, 2019) Sahin, Kazim; Ojalvo, Sara Perez; Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Sahin, Nurhan; Ozercan, Ibrahim H.
    The purpose of this study was to test the effects of arginine-silicate-inositol complex (ASI), compared to a combination of the individual ingredients (A + S + I) of the AM, on inflammatory markers and joint health in a collagen-induced arthritis (CIA) rat model. A total of 28 Wistar rats were divided into four groups: (i) Control; (ii) Arthritic group, rats subjected to CIA induction by injection of bovine collagen type II (A); (iii) Arthritic group treated with equivalent doses of the separate components of the ASI complex (arginine hydrochloride, silicon, and inositol) (A + S + I); (iv) Arthritic group treated with the ASI complex. The ASI complex treatment showed improved inflammation scores and markers over the arthritic control and the A + S + I group. ASI group had also greater levels of serum and joint-tissue arginine and silicon than the A + S + I group. Joint tissue IL-6, NF-kappa B, COX-2, TNF-alpha, p38 MAPK, WISP-1, and beta-Catenin levels were lower in the ASI group compared to the other groups (P < 0.05 for all). In conclusion, these results demonstrate that the ASI complex may be effective in reducing markers of inflammation associated with joint health and that the AM complex is more effective than a combination of the individual ingredients.