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    Hypochlorous acid for accidental vincristine overdose: A preliminary experimental study
    (Inst Exp Pathol Oncol Radiobiol, 2003) Ozgen, U; Stout, M; Turkoz, Y; Ozugurlu, F; Kutlu, NO; Soylu, H; Koltuksuz, U
    Aim: to investigate the potential efficacy of in vivo treatment of accidental vincristine (VCR) overdose using hypochlorous acid (HOCl). Methods: 24 New Zealand rabbits were divided into 4 groups as control, HOCl-treated, VCR + treated and HOCl + VCR-treated, and their clinical and laboratory indexes were examined. Results: there were no clinical and laboratory abnormalities observed in control and HOCl group subjects. All rabbits died after quadriplegia and respiratory insufficiency in VCR and HOCl + VCR groups. Bone marrow suppression was more pronounced and onset of the neurotoxicity was early in VCR group compared to HOCl + VCR group subjects. Serum half-life of VCR was lower in HOCl + VCR group animals suggesting a contribution of HOCl in eliminating VCR resulting in the observed clinical and laboratory differences in these two groups. Conclusion: although further research is necessary, our results indicate a potential role for HOCl in the treatment of accidental VCR overdose.
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    Periorbital solitary-type infantile myofibromatosis
    (Slack Inc, 1997) Bayramlar, H; Hepsen, IF; Sarac, K; Hasanoglu, A; Tecimer, T; Ozgen, U; Senol, M
    [Abstract Not Available]
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    Severe epistaxis in brucellosis-induced isolated thrombocytopenia: A report of two cases
    (Blackwell Science Ltd, 2000) Sevinc, A; Kutlu, NO; Kuku, I; Ozgen, U; Aydogdu, I; Soylu, H
    Brucellosis can present initially with its haematological findings including anaemia, leukopenia, and thrombocytopenia and may mimic primary haematological diseases. We present two patients with complaints of severe epistaxis and isolated thrombocytopenia which was initially diagnosed as idiopathic thrombocytopenic purpura but which was finally attributed to brucellosis. Their platelet count reverted to normal within 2-3 weeks of initiating antibrucellosis treatment with recovery from the disease.