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    The Impact of Vaccination Among Hospitalized Patients with the Diagnosis of COVID-19
    (Doc Design Informatics Co Ltd, 2023) Yildiz, Yesim; Ozger, Hasan Selcuk; Acar, Ali; Seremet-Keskin, Aysegul; Binay, Umut Devrim; Unlu, Gulten; Bayram, Halim
    Objective: We aimed to investigate the vaccination status and the risk factors for the intensive care unit (ICU) support need of the laboratory-confirmed breakthrough COVID-19 infection inpatients. Materials and Methods: This multi-center point-prevalence study was conducted on inpatients, divided into two groups as 'fully' and 'partially' vaccinated according to COVID-19 vaccination status. Results: Totally 516 patients were included in the study. The median age was 65 (55-77), and 53.5% (n=276) of the patients were male. Hypertension (41.9%, n=216), diabetes mellitus (DM) (31.8%, n=164), and coronary artery disease (CAD) (16.3%, n=84) were the predominant comorbidities. Patients were divided into two groups ICU (n=196) and non-ICU (n=301). Hypertension (p=0.026), DM (p=0.048), and congestive heart failure (CHF) (p=0.005) were significantly higher in ICU patients and the median age was younger among non-ICU patients (p=0.033). Of patients, 16.9% (n=87) were fully vaccinated, and this group's need for ICU support was statistically significantly lower (p=0.021). Conclusion: We conclude that older age, hypertension, DM, CHF, and being partially vaccinated were associated with the need for ICU support. Therefore, all countries should continuously monitor post-vaccination breakthrough COVID-19 infections to determine the national booster vaccine administration approach that will provide vulnerable individuals the highest protection.
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    Outbreak of bacteremia caused by Ralstonia insidiosa isolated from a contaminated blood gas syringe
    (Tubitak Scientific & Technological Research Council Turkey, 2025) Sahin, Elif Ayca; Ozgen Top, Ozge; Aysert Yildiz, Pinar; Tanriverdi, Elif Seren; Ozger, Hasan Selcuk; Otlu, Baris; Guzel Tunccan, Ozlem
    Background/aim: Ralstonia species are opportunistic, waterborne microorganisms known for their ability to survive and proliferate in a wide range of water-based environments. They can contaminate solutions used for patient care and cause hospital outbreaks due to contaminated solutions. The aim of this study was to investigate the source and clonal relationship of Ralstonia insidiosa bacteremia detected in 28 patients between August and December 2021, as part of an unusual outbreak. Materials and methods: Active prospective surveillance studies were conducted, and environmental samples, including saline, antiseptic, and antibiotic solutions, injectors, arterial blood gas syringes, tap water, and hand soap, were collected from wards to determine the source of the outbreak. An arbitrary-primed polymerase chain reaction (AP-PCR) genotyping method was used to determine the clonal relationship between the isolates. Results: All the samples were cultured, and R. insidiosa was isolated from arterial blood gas syringes with the same location and time- based identifier (LOT number). All the arterial blood gas syringes were recalled from the hospital departments and sent back to the manufacturer. The outbreak was reported to the national health authorities. Clonal analysis between isolates from the patients and the blood gas syringes was performed using AP-PCR. It was observed that the R. insidiosa isolates were monoclonal and identical. Conclusion: It was concluded that these contaminated arterial blood gas syringes caused the R. insidiosa bacteremia, especially in immunocompromised patients.