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    Effects of cyanocobalamin on immunity in patients with pernicious anemia
    (Karger, 2008) Erkurt, Mehmet Ali; Aydogdu, Ismet; Dikilitas, Mustafa; Kuku, Irfan; Kaya, Emin; Bayraktar, Nihayet; Ozhan, Onur
    Objective: The aim of the study was to evaluate the role of vitamin B-12 in patients with pernicious anemia. Materials and Methods: This study was conducted prospectively at the Turgut Ozal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B-12 effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. Results: In vitamin B-12-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. Conclusion: These findings suggest that vitamin B-12 has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B-12 replacement therapy. Copyright (C) 2008 S. Karger AG, Basel.
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    Fulminant progression of peripheral T-cell lymphoma with skin involvement mimicking zona zoster: Letter to editor
    (2012) Demircioğlu, Sinan; Aydoğdu, İsmet; Erkurt, Mehmet Ali; Gürses, İclal; Kuku, İrfan; Kaya, Emin; Ozhan, Onur
    Abstract: Burada periferik T hücreli lenfomalı bir erkek hasta sunduk. Hasta remisyona girdikten iki ay sonra nüks etti. Kurtarma tedavisi sırasında vefat etti. Periferik T hücreli lenfomalar kötü prognoza sahiptir ve agresif seyir gösterirler. Hastalar hızlı değerlendirilmelidir. Çünkü kemoterapinin başarı şansı düşüktür. Tedavi için kemik iliği nakli akılda tutulmalıdır.
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    Serum Zinc Levels in Iron Deficient Women: A Case-Control Study
    (Galenos Yayincilik, 2016) Ozhan, Onur; Erdem, Neslihan; Aydogdu, Ismet; Erkurt, Ali; Kuku, Irfan
    Since similar symptoms and findings can be seen in the deficiencies of both iron and zinc, we aimed to evaluate the serum zinc levels of women with iron deficiency anemia (IDA). This study was conducted with women with iron deficiency and a healthy control group. When serum zinc levels were compared, they were found to be lower in the IDA group, which was statistically significant. With the help of these studies, iron and zinc treatment instead of only iron replacement may be considered in cases of iron deficiency.