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Öğe Effects of cyanocobalamin on immunity in patients with pernicious anemia(Karger, 2008) Erkurt, Mehmet Ali; Aydogdu, Ismet; Dikilitas, Mustafa; Kuku, Irfan; Kaya, Emin; Bayraktar, Nihayet; Ozhan, OnurObjective: The aim of the study was to evaluate the role of vitamin B-12 in patients with pernicious anemia. Materials and Methods: This study was conducted prospectively at the Turgut Ozal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B-12 effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. Results: In vitamin B-12-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. Conclusion: These findings suggest that vitamin B-12 has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B-12 replacement therapy. Copyright (C) 2008 S. Karger AG, Basel.Öğe Fulminant progression of peripheral T-cell lymphoma with skin involvement mimicking zona zoster: Letter to editor(2012) Demircioğlu, Sinan; Aydoğdu, İsmet; Erkurt, Mehmet Ali; Gürses, İclal; Kuku, İrfan; Kaya, Emin; Ozhan, OnurAbstract: Burada periferik T hücreli lenfomalı bir erkek hasta sunduk. Hasta remisyona girdikten iki ay sonra nüks etti. Kurtarma tedavisi sırasında vefat etti. Periferik T hücreli lenfomalar kötü prognoza sahiptir ve agresif seyir gösterirler. Hastalar hızlı değerlendirilmelidir. Çünkü kemoterapinin başarı şansı düşüktür. Tedavi için kemik iliği nakli akılda tutulmalıdır.Öğe Molsidomine (MOL) reduces postoperative pelvic adhesion: A rat uterine horn model(2019) Koleli, Isil; Parlakpinar, Hakan; Ozhan, Onur; Tanbek, Kevser; Sahin, Nurhan; Yilmaz, Ercan; Sariibrahim, Bahar; Bakir, LaleAim: Postoperative pelvic adhesions (PPAs) are a common complication that leads to many problems. This study aimed to compare the role of Seprafilm (a protective barrier), and molsidomine (MOL), recognized for its antioxidative and antiproliferative effects, in preventing pelvic adhesion. Material and Methods: A total of 30 of female Wistar albino rats were randomly divided into 3 groups. They underwent bilateral uterine horn injury. The rats in the Sham group (n=10) received no special treatment. The rats in the Seprafilm group (n=10) were treated withSeprafilm. The rats in the MOL group (n=10) received 10 mg/kg MOL orally for 14 days. Adhesion scores were evaluated using macroscopic, microscopic, and immunohistochemical grading 14 days postoperatively. Results:The Majuzi adhesion score of the rats in the MOL group [1 (0-4)] was lower than the score of the rats in the sham [4 (2-5)] and Seprafilm [4 (1-5)] (p<0.05). The glutathione peroxidase level in the MOL group [9.34 (5.45 - 19.82)] was higher than that in the sham [7.05 (2.67 – 8.9)] and Seprafilm [5.85 (3.92 - 22.55)] groups (p<0.05). Conclusions: This study showed that MOL reduced the formation of PPAs in a rat uterine horn model.The need for larger studies is an obvious need to elucidate this issue.Öğe Serum Zinc Levels in Iron Deficient Women: A Case-Control Study(Galenos Yayincilik, 2016) Ozhan, Onur; Erdem, Neslihan; Aydogdu, Ismet; Erkurt, Ali; Kuku, IrfanSince similar symptoms and findings can be seen in the deficiencies of both iron and zinc, we aimed to evaluate the serum zinc levels of women with iron deficiency anemia (IDA). This study was conducted with women with iron deficiency and a healthy control group. When serum zinc levels were compared, they were found to be lower in the IDA group, which was statistically significant. With the help of these studies, iron and zinc treatment instead of only iron replacement may be considered in cases of iron deficiency.
