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    Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome
    (Elsevier Science Inc, 2010) Ozkaya, Mesut; Cakal, Erman; Ustun, Yusuf; Engin-Ustun, Yaprak
    Objective: To evaluate serum visfatin levels and to determine the effects of metformin treatment on visfatin levels in patients with polycystic ovary syndrome (PCOS). Design: Cross-sectional study. Setting: University hospital. Patient(s): Nineteen patients with PCOS and 21 controls. Intervention(s): Metformin was given to patients with PCOS, and serum visfatin levels were measured before and after treatment. Main Outcome Measure(S): Glucose, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, DHEAS, total T, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and visfatin levels were measured. Result(s): Serum visfatin levels were significantly higher in women with PCOS than in controls. Visfatin could differentiate between women with and without increased diabetogenic risk at a cut-off value of 19.24 ng/mL, with a sensitivity of 93.3% and a specificity of 84%. In bivariate analysis of subjects, T, insulin, and waist circumference were significantly and positively correlated with visfatin. Treatment resulted in a significant decrease in body mass index and a decrease in visfatin concentration. After therapy, statistically significant decreases in HOMA-IR, fasting insulin, free T, and DHEAS concentrations were observed for the PCOS group. Conclusion(s): Circulating visfatin levels were higher in patients with PCOS than healthy controls, and metformin treatment significantly reduced circulating visfatin concentrations after 3 months of therapy. (Fertil Steril (R) 2010:93:880-4. (C)2010 by American Society for Reproductive Medicine.)
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    Temperament and Character Traits of The Patients with Type 2 Diabetes
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Biter, Elif; Bagcioglu, Erman; Bahceci, Bulent; Ozer, Ali; Ozkaya, Mesut; Karaaslan, Mehmet Fatih
    Objective: The aim of this study was to evaluate the differences among dimensions of temperament and character within type 2 diabetes patients. Methods: Temperament and character inventory, Montgomery-Asberg Depression Rating Scale, Hamilton Anxiety Rating Scale were administered to type 2 diabetes patients and control groups. Results: Anxiety and depression scores were significantly higher in patients with type 2 diabetes (p=0.0001 and p=0.009, respectively). According to inventory, the scores of harm avoidance-fatigability, self directednessresourcefulness, and cooperativeness-helpfulness of patients were significantly different from controls (p=0.001, p=0.004 and p=0.040, respectively). Conclusions: Our research findings indicate that the patients with type 2 diabetes differ from the control group members in terms of higher levels of anxiety and depression as well as the temperament and character traits of fatigability; resourcefulness and helpfulness.