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    Brain diffusion-weighted imaging in diabetic patients with retinopathy
    (Verduci Publisher, 2012) Dogan, M.; Ozsoy, E.; Doganay, S.; Burulday, V.; Firat, P. G.; Ozer, A.; Alkan, A.
    Objective: Our aim was to detect whether there is any change in apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the vision, in diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI). Materials and Methods: Conventional magnetic resonance imaging (MRI) and DWI of the brain were obtained from 45 diabetic patients (15 patients with proliferative diabetic retinopathy (group 1), 15 patients with nonproliferative diabetic retinopathy (group 2), 15 diabetic patients without retinopathy (group 3) and from 15 age-matched healthy volunteers (group 4). ADC values of visual cortex, cingulate gyrus, orbitofrontal, dorsomedial and dorsolateral frontal, corona radiate, and thalamus were obtained. Results: The ADC values of visual cortex, cingulate gyrus and orbitofrontal cortex significantly increased in groups 1 and 2 compared to groups 3 and 4 (p < 0.001). The ADC values of visual cortex significantly increased in group 1 compared to group 2 (p < 0.001). The duration of disease and value of HbA1c positively correlated with ADC values of the visual and orbitofrontal cortexes, and cingulate gyrus. Conclusions: We found an increase in ADC values supporting the neuronal loss in some regions, especially in visual center by DWI in the diabetic patients with retinopathy. This result supports the association between diabetic retinopathy and brain injury.
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    The influence of soft contact lenses on the intraocular pressure measurement
    (Nature Publishing Group, 2012) Firat, P. G.; Cankaya, C.; Doganay, S.; Cavdar, M.; Duman, S.; Ozsoy, E.; Koc, B.
    Purpose To evaluate the influence of silicone hydrogel contact lenses on the intraocular pressure (IOP) measurement using Goldmann applanation tonometry (GAT), non-contact tonometry (NCT), and Pascal dynamic contour tonometry (DCT). Methods We included in the study 40 eyes of 40 patients who did not have any ocular or systemic diseases or contraindications to contact lens use. We measured and recorded the IOP values of each patient using NCT without and with contact lenses (groups 1 and 2, respectively), using DCT without and with contact lenses (groups 3 and 4, respectively), and using GAT without contact lenses (group 5). Results The mean IOP value of group 1 was 14.55 +/- 2.95 mmHg and 13.92 +/- 2.58 mmHg in group 2. We detected no statistically significant difference between group 1 and group 2 (P = 0.053). The mean IOP values for group 3 and group 4 were 16.26 +/- 2.33 mmHg and 15.19 +/- 2.40 mmHg, respectively. We detected a statistically significant difference between groups 3 and 4 (P = 0.005). Group 5's mean IOP value was 12.97 +/- 2.65 mmHg. IOP values measured with DCT were statistically significantly higher compared with IOP values measured with NCT and GAT (P < 0.0001 and P < 0.0001, respectively). Additionally, IOP values measured with NCT were statistically significantly higher compared with IOP values measured with GAT (P < 0.0001). Conclusion According to the results of our study, silicone hydrogel soft contact lens use does not significantly affect IOP values measured with NCT, but it affects IOP values measured with DCT. Eye (2012) 26, 278-282; doi:10.1038/eye.2011.271; published online 11 November 2011