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Öğe Beta-glucan attenuates cerebral ischemia/reperfusion-induced neuronal injury in a C57BL/J6 mouse model(Univ Sao Paulo, Conjunto Quimicas, 2019) Kaya, Kursat; Ciftci, Osman; Oztanir, Mustafa Namik; Taslidere, Elif; Turkmen, Nese BasakBeta-glucans (beta g), that have many useful effects on human health, are natural polysaccharides. Our aim in this study was to determine useful effect of beta g against oxidative and neuronal damage caused by global cerebral ischemia/reperfusion (IR) in stroke imitated mice via surgical operation. A total of 40 mice divided into four equal groups randomly. The group 1 (sham operated) was kept as control. Bilateral carotid arteries of subjects in group 2 (I/R) and group 4 (I/R + beta g) were clipped for 15 min, and the mice in group 4 (I/R + beta g) were treated with beta g (50 mg/kg/day), while the mice in group 2 (I/R) were treated with only vehicle for 10 days. The mice of group 3 (beta g) were treated with beta g for 10 days without carotid occlusion. Global cerebral I/R significantly increased oxidative stress and decreased members of anti-oxidant defense system. In addition, I/R caused histopathological damage in the brain tissue. However, beta g treatment ameliorated both oxidative and histopathological effects of I/R. Our present study showed that beta g treatment significantly ameliorated oxidative and histological damage in the brain tissue caused by cerebral I/R. Therefore, beta g treatment can be used as supportive care for ischemic stroke patients.Öğe The Evaluation of Vertebrobasilar Artery System in Neuro-Behcet and Behcet Disease using Magnetic Resonance Angiography(Wiley, 2014) Kose, Evren; Kamisli, Suat; Dogan, Metin; Tasolar, Sevgi; Kahraman, Aysegul; Oztanir, Mustafa Namik; Sener, SerpilThe aim of this study is the evaluation of the vertebrobasilar artery system in patients with Behcet's and Neuro-Behcet's disease. For this aim; 20 adults with clinically diagnosed Behcet's disease, 20 adults with Neuro-Behcet's disease, and 19 age-and gender-matched controls were examined by magnetic resonance angiography (MRA). During MRA, diameters of left vertebral artery (LVA), right vertebral artery (RVA), basilar artery (BA), and proximal segment (P1) of posterior cerebral artery between origin and junction with the posterior communicating artery were measured. In all groups, LVA was dominant than RVA (P < 0.05). The diameters of BA and right P1 of Neuro-Behcet's disease were larger than the other groups (P < 0.05). In addition, the diameters of left P1 of Neuro-Behcet's disease were larger but not statistically significant. There is no difference between the groups in terms of gender. Behcet's disease can affect vascular structures; therefore vertebrobasilar artery system should be examined in patients with Behcet's and Neuro-Behcet's disease. (C) 2014 Wiley Periodicals, Inc.Öğe Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury(Termedia Publishing House Ltd, 2019) Kamisli, Suat; Basaran, Cenk; Batcioglu, Kadir; Oztanir, Mustafa Namik; Gul, Mehmet; Satilmis, Basri; Uyumlu, Ayse BurcinIntroduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study. Material and methods: Global cerebral ischemia was induced for five minutes in adult male Wistar Albino rats via the 4-vessel occlusion method. Intravenous administration of 1 mg/kg RS100642 following reperfusion for 30 min (RS100642 group) was compared with a sham treatment group (ischemia group) and nonischemized group (control) histologically based on morphology and caspase-3 immunohistochemistry, and biochemically based both on measurement of oxidative stress including malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and on assessment of apoptosis including caspase-3 and -8 activities and tumor necrosis factor alpha (TNF-alpha) levels at the end of 6 h. Results: While the RS100642 group had significantly lower MDA levels and higher SOD activities than the sham treatment group (p < 0.05), GPx and CAT activities of the RS100642 and sham treatment groups were similar (p > 0.05) and significantly lower than those of the controls (p < 0.05). Necrosis and caspase-3 activity and immunoreactivity in the RS100642 group were significantly lower than those in the sham treatment group (p < 0.05), while there was no significant difference between groups regarding caspase-8 and TNF-alpha (p > 0.05). Conclusions: Na+ channel blockade by RS100642 has remarkable neuroprotective effects following global brain ischemia/reperfusion damage. Further research is required to determine the optimum dose and time of administration.Öğe Qual e a eficacia do beta-glucano no tratamento da otite media aguda?(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2021) Cetinkaya, Erdem Atalay; Ciftci, Osman; Alan, Saadet; Oztanir, Mustafa Namik; Basak, NeseResumo Introducao: Como suplemento, o beta-glucano apresenta varios efeitos terapeuticos gerados pelas celulas imunologicas. Cientificamente aprovado, mostrou ser um modificador de defesa biologica. Objetivo: Investigar os efeitos do beta-glucano nos tratamentos administrados em um modelo de otite media aguda induzida em um modeloanimal. A eficacia foi avaliada imunologica e histologicamente. Metodo: A amostra do estudo foi composta por 35 ratos adultos, divididos aleatoriamente em 5 grupos de 7: grupo 1 (controle), grupo 2 (otite media aguda, sem tratamento), grupo 3 (otite media aguda + antibiotico), grupo 4 (otite media aguda + beta-glucano) e grupo 5 (otite media aguda + beta-glucano + antibiotico). Foram feitas analises dos resultados dos exames histopato-logicos e imunologicos em relacao ao espessamento da membrana timpanica, dano ao epitelio, inflamacao e esclerose. Os niveis sericos de TNF-ci, IL-4, IL-6 e IL-113 foram avaliados em todos os grupos. Resultados: Todos os niveis sericos de citocinas foram significativamente mais baixos nos grupos tratados com beta-glucano e antibioticos em comparacao com o grupo otite media aguda. Diferencas significativas na espessura da membrana timpanica, inflamacao, dano do epitelio e esclerose foram observadas entre os grupos otite media aguda + antibiotico e otite media aguda + beta-glucano. De acordo com esses parametros, os valores no grupo otite media aguda + antibiotico + beta-glucano foram acentuadamente inferiores aos dos demais grupos. Houve uma diferenca significante no grupo otite media aguda + antibiotico + beta-glucano em comparacao ao grupo otite media aguda (p < 0,001). Conclusao: Ambos os tratamentos com antibiotico e com beta-glucano reduziram os sinais de inflamacao da otite media aguda em um modelo de rato com otite media aguda induzida, diminuiram os danos histologicos e os niveis de citocinas. A administracao concomitante de antibiotico e beta-glucano levou a uma reducao significativa na espessura da membrana tim-panica, inflamacao e danos ao epitelio. O tratamento com antibioticos + beta-glucano resultou em maior diminuicao na espessura da membrana timpanica, inflamacao e danos no epitelio do que nos outros grupos. A partir desses resultados, pode-se sugerir que o beta-glucano, em combinacao com antibioticos, pode fornecer uma opcao para o tratamento da otite media aguda. (c) 2020 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Publicado por Elsevier Editora Ltda. Este e um artigo Open Access sob uma licenca CC BY (http:// creativecommons.org/licenses/by/4.0/).Öğe Red and White Thrombus Characteristics in Patients Undergoing Carotid Endarterectomy(Elsevier, 2021) Tosun, Hatice; Kamisli, Suat; Tecellioglu, Mehmet; Alan, Saadet; Tecellioglu, Fahriye Secil; Oztanir, Mustafa Namik; Kablan, YukselObjective: The study aimed to compare the characteristics of red and white thrombi in patients undergoing carotid endarterectomy. Material and Methods: The study was conducted in 81 patients with ischemic stroke who underwent carotid endarterectomy for carotid artery stenosis. Carotid plaques were graded by two pathologists. Thrombus materials were divided into two groups: white and red. The parameters of assessment were plaque rupture, lipid core, fibrous cap thickness, inflammation, intraplaque hemorrhage, calcification, necrotic core, and neovascularization. Normally distributed data were evaluated using Mann-Whitney U and Chi-squared tests. Results: The ratio of white and red thrombus was 19.8% and 80.2%, respectively. Lipid core, plaque rupture, necrotic core, neovascularization, intraplaque hemorrhage, obstruction, and inflammation were observed more in red thrombus, which were statistically significant. Calcification and fibrous cap thickness were not statistically significant in the two groups. Moreover, intimal smooth muscle cells were present in all thrombus types. Conclusion: In our study, we found that red thrombi had more unstable characteristics than white thrombi. Thus, the risk for ischemic cerebrovascular events is more in red thrombi. However, this finding cannot be generalized due to the small number of patients in this study. Therefore, studies involving more patients are needed.Öğe Secukinumab Ameliorates Oxidative Damage Induced by Cerebral Ischemia-Reperfusion in Rats(Turkish Neurosurgical Soc, 2022) Oztanir, Mustafa Namik; Dogan, Muhammed Fatih; Basak Turkmen, Nese; Taslidere, Asli; Sahin, Yasemin; Ciftci, OsmanAIM: To investigate the histological and biochemical neuroprotective effects of secukinumab (SEC) on cerebral ischemia-reperfusion (IR) injury in Sprague-Dawley male rats. MATERIAL and METHODS: A total of 28 Sprague-Dawley male rats were randomly and equally divided into the following four groups: Sham, SEC, IR, and IR+SEC groups. Bilateral common carotid arteries were simultaneously separated and blocked for 15 minutes using two vascular mini clips in the IR and IR+SEC groups. The surgical procedure was similarly repeated in the Sham and SEC groups, but the carotid arteries were not clipped. Secukinumab was administered intraperitoneally to the SEC and IR+SEC groups once a week after the surgical procedure. Rat brain tissues were collected for biochemical analysis and histopathological examination 14 days after surgery. RESULTS: Cerebral IR caused abnormal changes in oxidative stress parameters by increasing the malondialdehyde (MDA) level and by decreasing the glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) levels. IR also induced histopathological alterations, such as vascular congestion, hemorrhage, and cell infiltration in the rat brain tissues. Secukinumab treatment significantly decreased the MDA levels and increased the GPx, GSH, CAT, and SOD levels. In addition, secukinumab partially prevented histopathological alterations in the brain tissues. The percentage of immunohistochemically Caspase-3-positive cells was high in the IR group; however, SEC decreased the density of cells stained with Caspase-3. CONCLUSION: IR injury was found to cause oxidative and histopathological changes in rat brain tissues, and secukinumab treatment ameliorated these pathological effects. Therefore, secukinumab may be useful to prevent and treat oxidative stress -induced brain damage in patients with ischemic stroke.Öğe Sudden-onset paraplegia during pregnancy caused by haemorrhage in a spinal cord haemangioblastoma: A case report(Pakistan Medical Assoc, 2016) Gormeli, Cemile Ayse; Sarac, Kaya; Ozdemir, Zeynep Maras; Gormeli, Gokay; Kahraman, Aysegul Sagir; Kahraman, Bayram; Oztanir, Mustafa NamikSpinal cord haemangioblastomas are rare central nervous systems tumours, and haemorrhage. It is an uncommon occurance. We report a 28-year-old pregnant patient who presented with paraplegia due to acute haemorrhage of a spinal haemangioblastoma. Magnetic resonance imaging showed extensive syrinx cavities, an intramedullary lesion at the T4-T5 spinal cord level e, and a subarachnoid haemorrhage. Digital subtraction angiography showed the feeding artery and dilated tortuous draining vein within the dural sac. The lesion was deemed a haemangioblastoma. The histopathological examination confirmed the diagnosis. Postoperatively, the paraplegia improved and the patient was able to walk within 2 weeks. Imaging is important for early diagnosis to prevent patients persistent neurological deficits.
