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    A clinically feasible kinematic assessment method of upper extremity motor function impairment after stroke
    (Elsevier Sci Ltd, 2016) Ozturk, Ali; Tartar, Ahmet; Huseyinsinoglu, Burcu Ersoz; Ertas, Ahmet H.
    The development of feasible kinematic assessment methods of upper extremity motor function impairment after stroke is clinically extremely important in physiotherapy and rehabilitation engineering. Microsoft Kinect has a potential of a low-cost and compact solution for clinical based assessment of the upper limb motor function after stroke. However, the reliability of Microsoft Kinect in the upper limb motor function assessment has not been well established. Therefore, there is a hesitation in usage of Microsoft Kinect for clinical applications. It is expected that any measurement procedure has the capability to differentiate between pathological and normal performance. On the other hand, the identification of the kinematic metrics that best evaluate impairment of upper-extremity motor function is a key problem of any measurement protocol. Primary objective of our study is, by differentiating pathological performance from the healthy performance and identifying the kinematic metrics that best evaluate the impairment, to demonstrate the robustness/usability of Microsoft Kinect in kinematic analysis of motor performance of stroke patients. We compared the kinematic metrics of the forward reaching movement obtained data recorded from Microsoft Kinect between three stroke patients and two healthy subjects based on the Principal Component Analysis (PCA). In the study, we have defined a new inter-joint coordination index (IJCI) based on PCA to capture inter-joint coordination dynamic of reaching movement in addition to other metrics those have been previously defined and used in literature to quantify upper limb impairment. We observed that the IJCI has significant importance to detect impairment of upper-extremity motor function during a forward reaching task and to discriminate stroke patients from healthy controls. We hope that this paper will promote the acceptance of objective kinematic analysis into routine rehabilitation practices. (C) 2015 Elsevier Ltd. All rights reserved.
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    Investigation of antifungal, antibiofilm and anti-filamentation activities of biocides against Candida isolates
    (2020) Ozturk, Ali; Abdulmajed, Olkar; Aydin, Merve
    Aim: This study was aimed to evaluate the antifungal, antibiofilm, and anti-filamentation activities of three commonly used biocides against clinical Candida isolates.Material and Methods: The in vitro activities of benzalkonium chloride (BZC), chlorhexidine digluconate (CHX), and triclosan (TRC) were studied against three Candida (C. albicans, C. parapsilosis, and C. glabrata) isolates. The isolates were identified, using the germ tube test, Cornmeal agar, and ID32 C (bioMerieux, France) kit. Antifungal susceptibility of these isolates was determined using the broth microdilution method. Antibiofilm activity of biocides were assessed with a colorimetric method based on crystal violet. The effect of biocides on the ability of C. albicans to form hyphae was examined microscopically.Results: The antifungal, antibiofilm, and anti-filamentation activities of biocides used were determined against Candida isolates. Antifungal activities of biocides against Candida isolates ranged from 1–4 µg/ml. The potent fungistatic effect of biocides tested was detected against Candida spp. at 1 µg/ml. All tested biocides showed good antifungal activity against Candida isolates. The results of the antibiofilm activity assay showed that the highest biofilm inhibition ratios were reported in BZC, CHX, and TRC (66%, 60.3%, and 58%, respectively) at 16 and 32 µg/ml. The lowest biofilm inhibition ratios were reported at MIC values for each biocide between 6% and 12%. In addition, the anti-filamentation activity of biocides tested was screened against C. albicans at concentrations of 1, 2, and 4 µg/ml of biocide and the inhibition rates varied from 10% to 59%.Conclusions: Important information has been obtained about the fungistatic/fungicidal, antibiofilm activities, and effects on C. albicans micromorphology of the biocides used in this study.
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    Seroprevalence of hepatitis E virus infection in acute leukemia patients with allogeneic transplantation
    (2020) Haydarlou, Mehdi Meskini; Ibahim, Bashar Mohammed Salih; Ozturk, Ali
    Aim: Hepatitis E Virus (HEV) infection is an emerging threat in allogeneic Hematopoietic Stem Cell Transplant (allo-HSCT) recipients. The aim of this study was to determine the prevalence of HEV infection in patients with acute leukemia before and after the transplantation.Material and Methods: The study was carried out with the serum samples taken before and after the transplantation from patients (n=42) with acute leukemia, who were 4 months to 64 years of age and who had allogenic transplant at Gazi University Hospital. All samples were tested in terms of HEV-specific anti-IgG and IgM positive value by using ELISA kit.Results: While 1 (2.3%) of the samples that were included in the study was positive anti-HEV IgG before transplantation, it was found negative after the transplantation (58th month). Positive anti-HEV IgM was not found before and after the transplantation in the collected samples. The average age of the seronegative group was determined as 30.8 ± 33.1 for male and female, respectively. There was no statistically significant difference in terms of anti-HEV IgM positivity and anti-HEV IgG positivity compared with seronegative cases of seropositive cases. Conclusions: This study was conducted to determine the prevalence of HEV infection in allogeneic stem cell patients. With this study, the incidence and importance of HEV can be determined in these patients before and after transplantation. This study can also create an important epidemiological data for our country.