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    Hemisection: A modern endodontic approach as an alternative treatment for the extraction of molar teeth-case series
    (2020) Tavsan, Oguz; Ozturk, Hasan; Simsek, Neslihan
    Hemisection is the separation of the whole tooth from the mesial to distal in the upper molars and premolars and from the buccal to lingual in the lower molars, and removal of the pathological root together with the crown. Hemisection is an appropriate treatment option when caries, resorption, iatrogenic complication or periodontal damage is limited to one root and the other root is relatively healthy. Hemisection of the affected tooth helps to preserve alveolar bone which surrounding the tooth structure and supports fixed dentures. Therefore, when a molar tooth should be extracted only because of damage at one root, hemisection or root amputation treatment alternatives should be kept in mind. This case series describes hemisection as a successful treatment method to recover teeth with iatrogenic complications and irretrievable root caries were limited to single root.
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    Osteogenic effects of metformin and exenatide on bone regeneration in non‑diabetic rats: A Micro‑CT and histological study
    (Wolters Kluwer Medknow Publications, 2025) Ozturk, Hasan; Simsek, Neslihan; Akinci, Levent; Ozgocmen, Meltem; Yigit, Dilek Helvacioglu
    Aim: This study aimed to evaluate the osteogenic effects of systemic metformin and exenatide administration on bone tissue regeneration in an experimental rat model by utilising micro‑computed tomography (micro‑CT) and histological analysis. Materials and Methods: Uniform craniotomy defects measuring 3 mm in diameter and 2 mm depth were performed in the parietal bones of 27 female albino Wistar rats, which were randomly divided into three groups: 1) a group receiving 100 mg/kg/day of oral metformin, 2) a group receiving 3 μg/kg/day of intraperitoneal exenatide, and 3) a control group receiving no medication. Bone volume and density at the defect site were evaluated using micro‑CT scanning and analysis. Results: Bone regeneration and the integration of newly formed bone into intact bone were assessed through histological and immunohistochemical examinations. In all three groups, the results showed no significant differences in bone volume, bone density, the presence of fibrous connective tissue, or the complete integration of the defect area into the bone tissue. However, the experimental groups exhibited significant differences in the number of osteoblasts (P = 0.007) and osteoclasts (P = 0.007) when compared to the control group. Conclusions: Metformin and exenatide enhance the activity of osteoblasts and osteoclasts in bone defects, promoting osteogenic potential during the healing process in non‑diabetic rats. © 2025 Journal of Oral and Maxillofacial Pathology.