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Öğe A case of erythema ab igne induced by laptop computer(2019) Ozturk, Murat; Dere, GokturkÖğe A case of flat wart that responds perfectly to isotretinoin(2019) Ozturk, Murat; An, IsaÖğe Clinical features of patients diagnosed with recidivan cutaneous leishmaniasis(2020) An, Isa; Ozturk, Murat; Aksoy, Mustafa; Yentur, Nebiye; Ayhan, Erhan; Eroglu, NaimeAim: Cutaneous leishmaniasis (CL) is a disease with chronic nodulo-ulcerative lesions on the skin that heals with atrophic scars. This study aims to investigate the clinical features of patients admitted to our clinic and diagnosed as recidivan CL.Material and Methods: This retrospective study included 11 patients who were admitted to our skin and venereal diseases clinic between October 2017 and July 2019 and who were diagnosed as recidivan CL by anamnesis, clinical and microscopic examination. Clinical characteristics of the patients such as age, sex, survival in the endemic region, intralesional or systemic antimony therapy and number, location, size and duration of the lesions were recorded.Results: Seven (63.6%) of the 11 patients were male and 4 (36.4%) were female. The mean age of the patients was 13.8 ± 4.04 years. All of the patients in the study had one lesion on their face. The mean lesion duration was 36.27 ± 24.3 months. The mean lesion size was 6.9 ± 3.4 cm. Before the diagnosis, 2 (18.2%) patients received intralesional antimony treatment, 1 patient (9.1%) received systemic antimony treatment, and 8 (72.7%) patients did not receive any treatment.Conclusion: In conclusion, recidivan CL is a rare form of chronic CL. Because parasites are rare in the lesions, the diagnosis is usually delayed and therefore the lesions can cause destruction and deformity. Prospective studies with a large number of patients are needed to better understand the clinical findings of recidivan CL.Öğe Evaluation of cardiometabolic function with serum adropin levels in psoriasis patients(2021) Onder, Sevda; Bayrak, Tulin; Kaya, Yasemin; Cankaya, Soner; Ozturk, MuratAim: Psoriasis is a skin disease with metabolic and cardiac comorbidities. Adropin is a peptide hormone which is thought to play a role in metabolic diseases, energy homeostasis, endothelial function and cardiac diseases in recent years. In this study, we aimed to evaluate adropin levels in psoriasis patients Materials and Methods: The study included 51 plaque psoriasis patients aged 18-65 years who had no systemic disease and had not received systemic treatment in the last three months and 37 healthy controls matched by sex, age and body mass index (BMI). Serum adropin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG), fasting blood glucose (FBG), fasting serum insulin, BMI, systolic blood pressure (SBP) and diastolic blood pressure (DBP) values were recorded. Results: Serum adropin level was 73.04 ± 46.21 pg / ml in the patient group. In the control group, serum adropin level was 77.26 ± 43.69 pg / ml. Serum adropin levels were lower in the patient group, but this was not statistically significant (p = 0.667). PASI value was negatively correlated with serum adropin level. There was no correlation between serum adropin level and other variables. Insulin level, Homa-IR level, systolic and diastolic pressure were significantly higher in the patient group (p <0.05). Conclusion: In our study, although adropin levels were not significantly lower in the patient group, we concluded that this may be associated with low PASI values. The role of adropin in psoriasis vulgaris will emerge with further studies.Öğe Evaluation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with lichen planus(2019) An, Isa; Ucmak, Derya; Ozturk, MuratAim: In recent years, neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and mean platelet volume (MPV) has been shown to be important indicators of systemicinflammation. Studies have shown that NLR and PLR are higher and that MPV is lower in lichen planus patients compared to the control group. In this study, NLR, PLR and MPV values of lichen planus patients were calculated and investigated whether these parameters were related to nail and oral mucosal involvement. Material and Methods: Eighty one patients with lichen planus without any systemic, infectious and autoimmune disease were included in this study while 81 patients who were admitted to the outpatient clinic for any non-inflammatory condition and whom had blood picture were included in the study as control group. Results: There was no statistically significant difference between neutrophil count, lymphocyte count, leukocyte count, platelet count, NLR and PLR values in LP patients and control group (p> 0.05). MPV value of LP patients had a mean of 8.10 ± 1.40 , and controls had a mean of 7.21 ± 1.45, and the difference was statistically significant (p <0.001). There wasn’t statistically significant relationship between neutrophil count, lymphocyte count, leukocyte count, platelet count, NLR, PLR and MPV values and nail and oral mucosa involvement (p> 0.05). Conclusion: It can be concluded that NLR and PLR were not suitable parameters to show inflammation in LP. The significant higher values of MPV in LP patients suggests that it may be used as a better marker of inflammation in LP patients than NLR and PLR. Nevertheless, the lack of significant association of MPV with nail involvement and oral mucosal involvement may restrict clinical use of it in LP.Öğe Expanding the phenotypic and genotypic characteristics of trichohepatoenteric syndrome: a report of eight patients from five unrelated families(Springer, 2024) Ozturk, Murat; Ates, Kubra; Esener, Zeynep; Mutlu, Hatice; Aydogmus, Cigdem; Boztug, Kaan; Sarac, HaticeBackground Trichohepatoenteric syndrome (THES) is characterized by neonatal-onset intractable diarrhea. It often requires long-term total parenteral nutrition (TPN). In addition, other characteristic findings of the syndrome include growth retardation, facial dysmorphism, hair abnormalities, various immunological problems and other rare system findings. Two genes and their associated pathogenic variants have been associated with this syndrome: SKIC3 and SKIC2. Methods and results In this case series, the clinical findings and molecular analysis results of a total of 8 patients from 5 different families who presented with persistent diarrhea and were diagnosed with THES were shared. Pathogenic variants were detected in the SKIC3 gene in 6 of our patients and in the SKIC2 gene in 2 patients. It was planned to compare the clinical findings of our patients with other patients, together with literature data, and to present yet-undefined phenotypic features that may be related to THES. In our case series, in addition to our patients with a novel variant, patient number 2 had a dual phenotype (THES and Spondyloepimetaphyseal dysplasia, sponastrime type) that has not been reported yet. Delay in gross motor skills, mild cognitive impairment, radioulnar synostosis, osteoporosis, nephropathy and cystic lesions (renal and liver) were observed as unreported phenotypic findings. Conclusions We are expanding the clinical and molecular repertoire of the syndrome regarding patients diagnosed with THES. We recommend that the NGS (next-generation sequencing) multigene panel should be used as a diagnostic tool in cases with persistent diarrhea.Öğe Neutrophil / Iymphocyte ratio, platelet / Iymphocyte ratio, mean platelet volume and C-reactive protein values in psoriatic arthritis patients(2019) An, Isa; Ucmak, Derya; Ozturk, Murat; Aksoy, Mustafa; Yildiz, Ismail; Ucan, EgemenAim: Studies have shown that neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio(PLR), mean platelet volume(MPV) and C-reactive protein(CRP) are higher in psoriatic arthritis patients than in the control group. In this study, NLR, PLR and MPV values of patients with psoriatic arthritis were calculated and if these parameters were related to CRP levels. Material and Methods: 74 psoriatic arthritis patients and 77 healthy controls without any systemic, infectious and autoimmune diseases were included in the study. Patients were divided into two groups according to their CRP values: normal (0-0.5 mg / dl) and high (> 0.5 mg / dl) Results: NLR, MPV and CRP values in the patient group were significantly higher than the control group. PLR value in the patient group was higher than the control group but the difference between them was not statistically significant. There was a statistically significant relationship between CRP and NLR and MPV values in psoriatic arthritis patients. Conclusion: Since NLR and MPV were significantly higher in psoriatic arthritis patients than in the control group and there was a statistically significant relationship with CRP elevation, it was thought that they were appropriate parameters to show inflammation in patients with psoriatic arthritis.Öğe Retrospective evaluation of clinical and demographic features of 135 patients with lichen planus(2018) An, Isa; Aksoy, Mustafa; Ozturk, Murat; Celik, HakimAim: Lichen planus (LP) is a chronic, inflammatory, papulosquamous skin disease with different clinical features. The incidence varies according to the geographical regions, although it is seen all over the world and all races. In this study, it was aimed to determine the clinical and demographic characteristics of patients with LP in our clinic. Material and Methods: We included 135 patients who applied to our clinic between January 2013 and December 2017 and who were diagnosed as LP by clinical and histopathological examination and who had HbsAg and Anti HCV tests. Patients’ age, sex, clinical variants of disease, mucosal involvement, nail involvement, HbsAg and Anti HCV tests were retrospectively recorded. Results: Of 135 patients included in the study, 68 (50.4%) were males and 67 (49.6%) females. The mean age of the patients ranged from 18 to 65 years, with a mean of 37.8 ± 12.7 years. Oral mucosal involvement was present in 30 (22.2%) patients and nail involvement in 10 (7.4%) patients. Classical LP was present in 111 of the patients (82.2%). HbsAg positivity was found in 3 of the patients (2.2%), but no anti HCV positivity was detected in any of the patients. Conclusion: The clinical and laboratory characteristics of the LP patients in our study were similar to the literature. More research which includes more patients is needed to better understand the clinical and epidemiological characteristics of LP.
