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    Artificial Intelligence-based Colon Cancer Prediction by Identifying Genomic Biomarkers
    (2022) Paksoy, Nur; Yağın, Fatma Hilal
    Aim: Colon cancer is the third most common type of cancer worldwide. Because of the poor prognosis and unclear preoperative staging, genetic biomarkers have become more important in the diagnosis and treatment of the disease. In this study, we aimed to determine the biomarker candidate genes for colon cancer and to develop a model that can predict colon cancer based on these genes.Material and Methods: In the study, a dataset containing the expression levels of 2000 genes from 62 different samples (22 healthy and 40 tumor tissues) obtained by the Princeton University Gene Expression Project and shared in the figshare database was used. Data were summarized as mean ± standard deviation. Independent Samples T-Test was used for statistical analysis. The SMOTE method was applied before the feature selection to eliminate the class imbalance problem in the dataset. The 13 most important genes that may be associated with colon cancer were selected with the LASSO feature selection method. Random Forest (RF), Decision Tree (DT), and Gaussian Naive Bayes methods were used in the modeling phase.Results: All 13 genes selected by LASSO had a statistically significant difference between normal and tumor samples. In the model created with RF, all the accuracy, specificity, f1-score, sensitivity, negative and positive predictive values were calculated as 1. The RF method offered the highest performance when compared to DT and Gaussian Naive Bayes.Conclusion: In the study, we identified the genomic biomarkers of colon cancer and classified the disease with a high-performance model. According to our results, it can be recommended to use the LASSO+RF approach when modeling high-dimensional microarray data. 
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    EVALUATION OF PATIENTS ADMISSING EMERGENCY CARE SERVICES FROM THE POINT OF VIEW OF FAMILY MEDICINE
    (2020) Kayhan Tetik, Burcu; Tetik, Bora; Karaoğlan, Aytaç; Alpağan, Cem; Mete, Burak; Paksoy, Nur
    Abstract: Objectives: Inappropriate use of Emergency Department (ED) for non-urgent complaints compromises the functioning of ED and has been increasing day by day. In this study, we examined the annual data of the patients who admitted to the Emergency Department in order to determine the ratio of appropriate usage according to the definitive diagnoses of the patients and to help forward new policies regarding this issue. Materials and Methods: Files of patients, who admitted to our ED between January 1 and December 31 , 2017, were examined. Data were evaluated by SPSS software version 22 , and the analyses were performed by using the Chi-square test. A value of p <0.05 was accepted to be statistically significant. Results: We found that 72.20% (n: 42785\59282) of the people who admitted to the ED during one year had admitted for complaints that should be addressed in the primary healthcare centers or specialist policlinics and only 19.2% (n: 11359\59282) of the ED visits were appropriate. We also found that the most frequent reasons for ED visits were respiratory system symptoms and pain. Conclusion: We found that the vast majority of the patients admitted to the emergency department were not actually urgent. We suggest that measures such as effectuation of the referral system for effective use of the family medicine system, use of triage in emergency departments, and extra fees for using the emergency department inappropriately can be implemented to reduce the workload in emergency services.
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    İnönü Üniversitesi Tıp Fakültesi 1. ve 6. Sınıf Öğrencilerinin Gözünden Hekime Şiddet Nedenleri
    (Acıbadem Sağlık Bilimleri Dergisi, 2018) Tetik, Burcu Kayhan; Bağ, Harika Gözükara; Paksoy, Nur; Tural, Cansu; Gedik, Işılay; Sertkaya, Serap
    ÖZET Amaç: Bu çalışmanın amacı 1. ve 6. Sınıf tıp fakültesi öğrencilerinin gözünden hekime şiddet nedenlerini araştırmak, bu konudaki bilgi düzeylerini belirleyebilmek ve sağlıkta şiddet ile ilgili farkındalıklarını artırabilmektir. Gereç - Yöntem: İnönü Üniversitesi Tıp Fakültesi 1. ve 6. Sınıf öğrencilerinden çalışmaya katılmayı kabul eden 246 öğrenci alınmıştır. Hekime neden şiddet uygulanabileceği ile ilgili hazırlanan sorulardan oluşan anket uygulanmıştır. Veriler SPSS 22 prog ile değerlendirilmiştir. Bulgular: Çalışmaya toplam 246 öğrenci katılmıştır. Öğrencilere en yaygın şiddet sebeplerinin ne olduğu sorulduğunda, dönem 1 öğrencilerinin %26.8’i, dönem 6 öğrencilerinin %61.3’ü “Muayene olmak için hastanın çok bekletilmesi” cevabını vermiş ve bu fark istatistiksel olarak anlamlı kabul edilmiştir (p<0.001). Aynı soruya dönem 1 öğrencilerinin %28.8’i dönem 6 öğrencilerinin %8.6‘sı “Doktorun hastayı muayene etmeden ilaç yazması” cevabını vermiş ve bu fark istatistiksel olarak anlamlı kabul edilmiştir (p<0.001). Sonuç: Toplumda yaygınlaşma eğilimi gösteren şiddet, sağlık sektörünü de ciddi biçimde etkilemektedir. Bu nedenle tıp fakültelerinde mezuniyet öncesi dönemde; hasta ile etkili iletişim kurabilme ve şiddete maruziyet durumunda sahip oldukları hukuki hakları ile ilgili derslerin müfredata eklenmesinin daha uygun olduğunu ayrıca yasal mevzuatın eksikliği de dikkate alınarak yeni hukuki düzenlemeler yapılabilmesi için ilgili mercilerle görüşmelerin yapılmasının gerekliliğini vurgulamak istedik. Anahtar sözcükler: Şiddet, tıp öğrencisi, etkili faktörler
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    Spondyloarthritis recovering after scorpion sting: A case report
    (2022) Kayhan Tetik, Burcu; Paksoy, Nur
    Scorpion venom, which is also utilized in Traditional Chinese Medicine, has been an efficient alternative medicine practice passed down from generation to generation since the Ancient Roman Period. Scorpion venom is now being investigated as a raw material (drug precursors) in a variety of sectors including new-generation pharmaceuticals. We present a 63-year-old male patient who had sacroiliitis symptoms that went away after a scorpion sting, and who recovered completely during follow-up. Apart from developing scorpion venom as a complementary therapy to existing medical techniques in the treatment of chronic inflammatory illnesses, more research into the effects of this prospective pharmaceutical on these diseases is required.