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    Comparison of the effects of midazolam and dexmedetomidine on cognitive functions, anxiety and hemodynamics in fiber optic bronchoscopy
    (2020) Perincek, Gokhan; Yagci, İbrahim
    Aim: Fiber optic bronchoscopy (FB) is an invasive method used in the diagnosis and treatment of lung diseases. There are several different sedation guidelines for FB, all of which are used by different healthcare providers. We aimed to compare the sedative effects of midazolam and dexmedetomidine in FB, together with their effects on cognitive functions, hemodynamic parameters, and patient satisfaction and anxiety. Material and Methods: The study includes a total of 80 randomly selected subjects aged ≥ 18 years. The subjects were divided into two groups: midazolam (n = 40) and dexmedetomidine (n = 40). We evaluated treatment outcomes using hemodynamic findings, the Mini-Mental State Examination, the State Anxiety Inventory, and a survey form.Results: The two groups were not significantly different in terms of systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, and peripheral oxygen values. Patient and medical professional satisfaction levels were significantly higher in the dexmedetomidine group. The cognitive functions and anxiety levels both before and after the intervention were similar for the two groups.Conclusion: We conclude that dexmedetomidine can be used safely for sedation in fiber optic bronchoscopy and is preferable to midazolam.
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    The predictors of 3-month mortality in community-acquired pneumonia
    (2021) Avci, Sema; Perincek, Gokhan
    Aim: The aim of the study was to compare the pneumonia severity scoring systems (PSI, CURB-65) and inflammatory markers (CRP, CAR, NLR and PLR) in predicting community-acquired pneumonia (CAP) patients’ 3-month mortality.Materials and Methods: This study included 113 patients (43 females, 70 males) diagnosed with CAP. Demographics, comorbidities, complete blood count, arterial blood gas, electrolytes, liver-renal functions and radiological findings were evaluated. PSI and CURB-65 were classified: PSI low risk (I-III, point ≤90); PSI moderate-high risk (IV-V, point 91≤); CURB-65; low risk (0-2) and high risk (3-5). All statistical calculations were performed with SPSS 23.0 for Windows.Results: The mean age of the patients was 69.08 ± 16.58 and 3-month mortality rate among the patients hospitalized on admission was 22.4% (n=24). Albumin, hemoglobin, lymphocyte, PaO2 were lower; NLR and lactate were higher in non-survivors. Albumin and lactate were higher in CURB-65 (0-2) and (3-5) groups, respectively. NLR was significantly higher in PSI group (IV-V). Red cell distribution width and lactate were lower in PSI (I-III); basophil and PaO2 were significantly lower in PSI group (IV-V). CRP (AUC 0.744), PSI classification (AUC 0.72) and PSI scoring (AUC 0.746) showed higher mortality prediction. Conclusion: Albumin, hemoglobin, lymphocyte, PaO2 were lower; NLR and lactate were higher in non-survivors. CRP and PSI score are potent predictors of 3-month mortality.
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    Prevalence of tandoor smoke exposure in female patients with asthma: A cross-sectional study from the East of Turkey
    (2019) Perincek, Gokhan
    Aim: The aim of this study was to evaluate the use of cow dung cake (cdc) for heating, cooking and baking in female patients (pts) with asthma.Material and Methods: This cross-sectional study was conducted between January 2016 and 2018. The study included 522 female pts with asthma. Pts were divided into three groups based on using cdc (for heating, cooking and baking). Secondly, the pts who used cdc in tandoor for baking were evaluated and these pts were divided into three groups based on exposure to tandoor smoke [a) currently using, b) previously used, c) never used]. Age, BMI, comorbidity, the place where pts live, educational status, occupation, smoking status, pulmonary functions and complete blood counts of all pts were evaluated. All statistical calculations were performed with SPSS 23.0.Results: 219 (42%) of all pts were using the cdc, 165 (31.7%) pts were using tandoor, 106 (20.4%) pts had previously used tandoor. The pts who exposed to tandoor smoke previously were significantly older and these pts had higher BMIs. The incidence of comorbidities, the place where pts live, occupation and educational status were significantly different between tandoor smoke exposure groups. The pts who were currently using tandoor for baking lived in villages. In all three groups, most of the women were housewives and most of them who were exposed to tandoor smoke were illiterate. Hemoglobin levels of the pts who were exposed to tandoor smoke were higher. The pts who were currently using tandoor for baking had significantly lower MPV and pulmonary function tests such as FEV1, FVC, PEF and FEF 25% levels. Conclusion: The women with asthma who exposed to tandoor smoke are older, overweight, rural housewife people and they have comorbidities. The pulmonary functions and hemoglobin of them may be affected by exposure to tandoor smoke.