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Öğe AKUT BATIN SENDROMUNUN NADİR BİR SEBEBİ: İLEOÇEKAL TÜBERKÜLOZ(2017) Çakır, Tuğrul; Polat, Cemal; Baştürk, Ahmet; Koç, SüleymanÖz: Gastrointestinal tüberküloz en sık görülen eks-trapulmoner tüberküloz tiplerindendir. Klinikte karın ağrısı, kilo kaybı, ateş, halsizlik, bulantı, iştahsızlık, kusma, distansiyon, gece terlemesi, diare, kabızlık gibi nonspesifik semptom ve bul-gular gösterir. İleoçekal bölgede kitleye bağlı akut karın sendromuna yol açması nadirdir. Hasta akut perfore apandisit ön tanısıyla ope-re edildi, fakat apandisitin ileoçekal tüberküloz kitlesine bağlı geliştiği görüldü ve sağ hemiko-lektomi ve ileotransversostomi uygulandı. Pos-toperatif dönemde bir sorun gelişmedi.Öğe Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?(Acta Cirurgica Brasileira, 2015) Cakiri, Tugrul; Basturk, Ahmet; Polat, Cemal; Aslaner, Arif; Durgut, Himmet; Sehirli, Ahmet Ozer; Gul, MehmetPURPOSE: To determine the antioxidant and anti-inflammatory effects of alfa lipoic acid (ALA) on the liver injury induced by methotrexate (MTX) in rats. METHODS: Thirty two rats were randomly assigned into four equal groups; control, ALA, MTX and MTX with ALA groups. Liver injury was performed with a single dose of MTX (20 mg/kg) to groups 3 and 4. The ALA was administered intraperitonealy for five days in groups 2 and 4. The other rats received saline injection. At the sixth day the rats decapitated, blood and liver tissue samples were removed for TNF-alpha, IL-1 beta, malondialdehyde, glutathione, myeloperoxidase and sodium potassium-adenosine triphosphatase levels measurement and histological examination. RESULTS: MTX administration caused a significant decrease in tissue GSH, and tissue Na+, K+ ATPase activity and which was accompanied with significant increases in tissue MDA and MPO activity. Moreover the pro-inflammatory cytokines (TNF-alpha, IL-beta) were significantly increased in the MTX group. On the other hand, ALA treatment reversed all these biochemical indices as well as histopathological alterations induced by MTX. CONCLUSION: Alfa lipoic acid ameliorates methotrexate induced oxidative damage of liver in rats with its anti-inflammatory and antioxidant effects.Öğe Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats?(E-Century Publishing Corp, 2015) Aslaner, Arif; Cakir, Tugrul; Celik, Betul; Dogan, Ugur; Mayir, Burhan; Akyuz, Cebrail; Polat, CemalMethotrexate is a chemotherapeutic agent used for many cancer treatments. It leads to toxicity with its oxidative injury. The purpose of our study is investigating the medical ozone preconditioning and treatment has any effect on the methotrexate-induced kidneys by activating antioxidant enzymes in rats. Eighteen rats were divided into three equal groups; control, Mtx without and with medical ozone. Nephrotoxicity was performed with a single dose of 20 mg/kg Mtx intraperitoneally at the fifteenth day of experiment on groups 2 and 3. Medical ozone preconditioning was performed at a dose of 25 mcg/ml (5 ml) intraperitoneally everyday in the group 3 and treated with medical ozone for five more days while group 2 was received only 5 ml of saline everyday for twenty days. All rats were sacrificed at the end of third week and the blood and kidney tissue samples were obtained to measure the levels of TNF-alpha, IL-1 beta, malondialdehyde, glutathione and myeloperoxidase. Kidney injury score was evaluated histolopatologically. Medical ozone preconditioning and treatment ameliorated the biochemical parameters and kidney injury induced by Mtx. There was significant increase in tissue MDA, MPO activity, TNF-alpha and IL-1 beta (P<0.05) and significant decrease in tissue GSH and histopathology (P<0.05) after Mtx administration. The preconditioning and treatment with medical ozone ameliorated the nephrotoxicity induced by Mtx in rats by activating antioxidant enzymes and prevented renal tissue.Öğe Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats(Taylor & Francis Inc, 2018) Arpag, Huseyin; Gul, Mehmet; Aydemir, Yusuf; Atilla, Nurhan; Yigitcan, Birgul; Cakir, Tugrul; Polat, CemalObjective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was performed with a single dose of MTX (20mg/kg) to groups 2 and 3. On the sixth day, animals in all groups were sacrificed by decapitation and lung tissue and blood samples were removed for histological examination and also measurement the levels of interleukin-1-beta (IL-1), malondialdehyde (MDA), glutathione (GSH), tumour necrosis factor-alpha (TNF-), myeloperoxidase (MPO), and sodium potassium-adenosine triphosphatase (Na+/K+ATPase). Results: In MTX group tissue GSH, Na+/K+ATPase activities were lower, tissue MDA, MPO and plasma IL-1?, TNF-? were significantly higher than the other groups. Histopathological examination showed that lung injury was less severe in group 2 according to group 3. Conclusions: Oxidative damage of MTX in rat lung is partially reduced when combined with ALA.
