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Öğe Aim: Although the the contribution of gamma-glutamyltransferase (GGT) to hyperuricemia (hUA) has been previously shown in literature, there is not any study showing the contribution of GGT to hUA in a Turkish population. The aim of this study was to investigate both the association between GGT and uric acid (UA) and the contribution of GGT to hUA in the Turkish population.Materials and Methods: This retrospective study was conducted in Antalya, Turkey. A total of 14049 subjects (5521 males and 8528 females) aged > 40 years were recruited and divided into four subgroups according to serum GGT quartiles. Patient demographic data and laboratory results of biochemical parameters were obtained from electronic medical records. Linear regression analysis was applied to GGT quartiles with UA and binary logistic regression analysis was applied to GGT quartiles with hUA.Results: Firstly, serum UA levels were increased across GGT quartiles (p 0.001). Linear regression models showed GGT in the fourth quartile was strong associated with a 0.22 mmol/L (95% confidence interval (CI) 0.16- 0.29, p = 0.001) increase in UA after adjustment. Logistic regression analysis revealed that compared with subjects in the lowest GGT quartile, the adjusted odds ratio (OR) for hyperuricemia in the fourth quartile was 2.62 (95% CI 2.27- 3.01, p = 0.001) after adjustment for age, sex, creatinine, total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), glycosylated hemoglobin (HbA1c) and alanine aminotransferase (ALT).Conclusions: Serum GGT is closely associated with serum UA and might contributes greatly to hUA.(2021) Kara, Burcak; Yilanci, Hilal; Ramoglu, Sabri IlhanAim: The aim of this study was to determine changes in bone structure after laser and piezo incisions evaluated with micro-computed tomography (micro-CT).Materials and Methods: Forty-eight adult male Sprague Dawley rats were randomly divided into 4 groups: no additional intervention to accelerate tooth movement (n=15), laser incision (n=15), piezocision (n=15), and control (n=3). These groups were divided into subgroups based on duration of applied force: 0, 3, 7, 14, 21, and 28 days. Piezo and laser incisions were made vertically on the mesial palatal side of the left maxillary molar without flap elevation. Tooth movement, bone volume, and bone mineral density were evaluated with micro-CT. P values less than 0.05 were considered statistically significant.Results: There were no significant differences in bone mineral density, bone volume, or amount of tooth movement between time points in any of the groups. The amount of tooth movement was significantly different between the groups at day 21.Conclusion: These findings provide some initial basic understanding of changes in the bone following tooth movement alone and with piezocision and laser incisions. Larger sample sizes are needed to better elucidate their effects.Öğe Comparison of the outcomes of the lower incisor extraction, premolar extraction and non-extraction treatments(Oxford Univ Press, 2012) Ileri, Zehra; Basciftci, Faruk Ayhan; Malkoc, Siddik; Ramoglu, Sabri IlhanThe aim of this retrospective study was to evaluate the treatment outcome of lower incisor extraction and to compare it with premolar extraction and non-extraction treatment. The sample consisted of 60 subjects with Class I malocclusion and moderate crowding. The sample was separated into three groups: extraction of a lower incisor group, extraction of a four first premolar group and a non-extraction group. All groups involved 13 girls and 7 boys with a total of 20 patients. The Peer assessment rating (PAR) index was applied to a patient's pre-treatment (T1) and post-treatment (T2) dental casts. T1 dental casts were also used for determining Bolton discrepancy. One-way analysis of variance and post hoc Tukey HSD tests were used for statistical analysis. For the mean percentage PAR score reduction for each group, there was one significant difference seen between the lower incisor extraction group and the non-extraction group (P = 0.047). For the mean anterior ratios, there were significant differences among premolar extraction group versus non-extraction group (P = 0.042) and non-extraction group versus lower incisor extraction group (P = 0.000). For the mean overall ratios, there were significant differences among the premolar extraction group versus lower incisor extraction group (P = 0.048) and the non-extraction group versus lower incisor extraction group (P = 0.001). Orthodontic treatment without extraction has a better treatment outcome than the four-first premolar extraction and single lower incisor extraction protocols in Class I cases with moderate to severe mandibular anterior crowding.
