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    Antihepatitis B response to hepatitis B vaccine administered simultaneously with tetanus toxoid in nonresponder individuals
    (Elsevier Sci Ltd, 2002) Sönmez, E; Sönmez, AS; Bayindir, Y; Coskun, D; Aritürk, S
    In this prospective study, our aim was to test the effect of simultaneous administration of preS2 and S containing recombinant hepatitis B vaccine (S2SRHB) with tetanus toxoid (TT) to the individuals who did not respond after three doses of hepatitis B vaccine previously. There were three groups (healthy individuals, pregnant women, hemodialysis patients), each was divided into two subgroups as groups A and B. Group A received S2SRHB + TT and group B received only S2SRHB. We found that in groups receiving both vaccines, both seroconversion rate and antibody titer level were significantly higher (P < 0.05). In conclusion, simultaneous administration of S2SRHB + TT is more effective than administration of S2SRHB alone. (C) 2002 Elsevier Science Ltd. All rights reserved.