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    Investigation of glycopeptide resistance in enterococcal strains isolated from Malatya, Kayseri and Elazi? Medical Faculty Hospitals
    (2001) Ersoy Y.; Sönmez E.; Young H.J.; A?el E.; Durmaz B.
    Enterococci are now receiving increased attention because of their resistance to multiple antimicrobial drugs, which probably explain their importance in nosocomial infections. The incidence of glycopeptide resistance of enterococci and detailed information about resistance genes has not yet been well recognized in our country. The aim of this study was to investigate the phenotypic and genotypic resistance of enterococci to glycopeptides, which were isolated from clinical specimens of patients in Medical Faculty Hospitals of Malatya, Kayseri and Elazi? Universities between the period from January 1998 to September 1999. A total of 235 enterococcus strains were included to the study and MIC values of vancomycin and teicoplanin for all isolates were determined by agar dilution method. All isolates were found to be susceptible to teicoplanin, but 11 strains showed intermediate resistance to vancomycin (4?g/ml?MIC?12?g/ml), while others were all susceptible. The vancomycin resistance genes of these 11 strains were investigated by single step polymerase chain reaction. As a result, vanC genes were detected in 7 strains and vanC2-3 genes in 2 strains, while there were no resistance genes in the other 2 isolates. In none of the strains vanB genes were positive. In conclusion, it has been suggested that the incidence of vancomycin resistance of enterococci in our region is not as high as in the other countries.