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Öğe Adrenomedullin and nitrite levels in children with Bartter syndrome(Springer-Verlag, 2000) Balat, A; Çekmen, M; Yürekli, M; Kutlu, O; Islek, I; Sönmezgöz, E; Çakir, MChildren with Bartter syndrome have lower than normal vascular reactivity with normotension in spite of biochemical and hormonal abnormalities which are typical of hypertension. Nitric oxide (NO) is a potent endogenous vasodilator, and plays an important role in the control of vascular tone. Adrenomedullin (AM) is a novel hypotensive peptide originally isolated from human pheochromocytoma. The possible role of NO and PLM in maintaining this reduced vascular reactivity was examined by studying plasma and urinary nitrite, a stable metabolite of NO, and AM levels in ten children with Bartter syndrome, ten healthy controls, and five children with hypokalemia of causes other than Bartter syndrome (pseudo-Bartter). Urinary excretion of nitrite (mu mol/mg urinary creatinine) was 8.9.+/-1.2 in children with Bartter syndrome, 4.7.+/-0.9 in healthy controls, and 2.9.+/-0.8 in pseudo-Bartter (P<0.05). Plasma nitrite levels (mol/l) were 101.9+/-23.4, 59.9+/-14.7, and 65.0+/-29.7, respectively (P>0.05), in the three groups. Urinary excretion of AM (pmol/mg urinary creatinine) was 187+/-40, 65+/-10, and 160+/-50, respectively (P<0.05), in the three groups. Plasma AM levels were 47.4+/-1.8, 39.9+/-5.9, and 42.4+/-3.9, respectively (P>0.05), in the three groups. The same parameters were repeated in the two groups of controls and in the Bartter patients in the 6th month of therapy. Urinary nitrite and AM levels were still higher in the Bartter patients than in the other groups. We conclude that in Bartter syndrome the increased NO production may be responsible for the reduced vascular response of the disease. Initially, increased levels of AM in Bartter syndrome and pseudo-Bartter may be a compensatory response to acute hypokalemia; however, continuation of a high level of urinary excretion of AM in children with Bartter syndrome may suggest also the possible role of AM in the reduced vascular response of the disease.Öğe A child with dehydration and severe hypernatraemia(Springer-Verlag, 2000) Soylu, H; Kutlu, NO; Sönmezgöz, E; Ertas, K[Abstract Not Available]Öğe The effects of androstenediol and dehydroepiandrosterone on the immune response to BCG at puberty(Oxford Univ Press, 2003) Kutlu, NO; Akinci, A; Sönmezgöz, E; Temel, I; Evliyaoglu, EIn order to assess the effects of age-related changes of serum dehydroepiandrosterone sulphate (DHEAS) and androstenediol (AED) concentrations on BCG vaccination throughout the puberty period, we matched 41 prepubertal (mean age 8.63+/-1.36 years, range 8-14 years) and 43 pubertal (mean age 13.8+/-1.31 years, range 10-16 years) schoolchildren who were PPD negative and free of disease or medication known to affect immune function. The tuberculin test was performed 8 weeks after vaccination and tuberculin response and hormone levels were compared between prepubertal and pubertal subjects. We found a higher tuberculin response in the pubertal group when compared with the prepubertal ones. The pubertal children had 79.1 per cent tuberculin positivity compared with 46.4 per cent of prepubertal children (p<0.05). Diameters of induration of the tuberculin test among prepubertal students vs. pubertal students were 9.5+/-3.8 mm and 11.9+/-3.7 mm, respectively (p<0.005). Pubertal stage, testis volume, and pubic stage were also found to have significant effects on tuberculin test results. No difference was observed between both sexes with regard to responses of the tuberculin test in either the prepubertal or the pubertal group (p>0.05). DHEAS and AED levels in the tuberculin-positive subjects were found to be significantly higher than tuberculin-negative ones (p=0.040 and p=0.046, respectively). Among both these hormones, only AED levels were correlated with tuberculin test responses. These results suggest that AED may play a role in the immunity to BCG vaccination and further immunological investigations are warranted to provide support for this idea.Öğe Prune-belly syndrome and pulmonary hypoplasia(Blackwell Science Asia, 2001) Soylu, H; Kutlu, NO; Sönmezgöz, E; Bükte, Y; Özgen, Ü; Akinci, A[Abstract Not Available]
