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Hepatit B Virüsü (HBV) Dna Miktarları ile Serum Alanin Aminotransferaz Düzeyleri ve HBV Serolojik Göstergeleri Arasındaki İlişki
(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2006) Kaya, Serpil; Yönem, Özlem; Özdemir, Levent; Sümer, Zeynep
We aimed to determine the relationship between serum HBV-DNA levels and serum alanine aminotransferase (ALT) levels in different age and sex groups. Materıal And Methods: Serum HBV-DNA levels of 90 patients with chronic HBV infection and serum alanine aminotransferase (ALT) levels were evaluated according to their age and sex retrospectively. Results: HBV-DNA levels of these patients were grouped as 1-5 pg/mL in 8.9%, 5-100 pg/mL in 45.6%, 101-2000 pg/mL in 27.8%, ³2000 pg/mL in 17.8%. ALT levels were grouped as ≤40 U/L in 26.7%, 41-60 U/L in 17.8%, 61-80 U/L in 13.3%, 81-100 U/L in 10.0%, >100U/L in 32.2% of the patients. There was a correlation between HBV-DNA and age. There were no a statistically significant difference between sex and age, serum HBV-DNA levels and serum ALT levels. Statistical significance were obtained between HBe antigenemi and age and serum HBV-DNA levels. Conclusion: Our results suggested that HBe seroconversion does not accurately determine infectivity and HBV- DNA levels may be very useful in diagnosis, therapy and follow-up periods of chronic HBV infection.