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    Decreased levels of plasma preptin in female patients with knee osteoarthritis
    (2019) Cakir, Murat; Sabah Ozcan, Seda; Korkmaz, Murat; Durusoy, Serhat
    Aim: Osteoarthritis (OA) is a common joint disease which is caused by the effects of mechanical, genetic and biochemical factors. In studies conducted in recent years, it has been shown that osteoblasts play roles in OA pathogenesis. In this study, we investigated the relation between the level of preptin, which is known to have an effect on osteoblast proliferation and differentiation, bone metabolism, and the OA disease.Materials and Methods: A total of 40 healthy control patients and 40 women who were diagnosed with knee OA were included in the present study. The plasma preptin levels of the individuals who were included in the study were measured with Enzyme-linked Immuno-Sorbent Assay (ELISA) Method. Blood glucose, triglyceride, High-Density Lipoprotein Cholesterol (HDL-c), Low-Density Lipoprotein Cholesterol (LDL-c), total cholesterol levels and Body Mass Indices (BMI) leukocyte, lymphocyte, neutrophil, Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) of all participants were measured.Results: The preptin levels of the knee OA patients in plasma were significantly lower (206 ± 103 ng/L) compared to the healthy control Group (501 ± 525 ng/L) (p0.001). In addition, the (CRP) levels (p0.02) and the Body Mass Indices (BMI) (p0.001) were also higher in the OA Group compared to the Control Group. Conclusion: In the present study, it was determined that there is a significant relation between knee OA disease and plasma preptin levels. Preptin may have roles in the pathogenesis of the OA disease. Further studies are needed to elucidate the mechanisms through which molecular mechanisms preptin is related to knee OA. Keywords: Osteoarthritis; knee; preptin; ELISA; plasma.
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    Decreased serum periostin level is associated with carpal tunnel syndrome
    (2020) Sabah Ozcan, Seda; Sacmaci, Hikmet; Cakir, Murat
    Aim: Noninflammatory subsynovial connective tissue (SSCT) fibrosis with nerve compression is an obvious feature of carpal tunnel syndrome (CTS). We investigated serum levels of periostin, which is known to have an effect on fibrosis, in patients with CTS. Material and Methods: A total of 39 healthy individuals and 32 patients who were newly diagnosed with CTS were included in this prospective clinical study. Duration of symptoms, severity, unilateral or bilateral side of CTS diagnosis of patients were recorded. Serum samples were received for the measurement of periostin levels from all participants and were analyzed using commercial enzyme-linked immunosorbent assay (ELISA) kits. Results: Serum periostin levels were significantly lower in CTS patients than controls (p=0.030). Additionally, there was no correlation between serum periostin levels and CTS disease regarding the duration of symptoms and electrophysiological severity of symptoms (p > 0.05).Conclusion: In the current study, it was evaluated that there is a significant relation between CTS and serum periostin levels. Periostin may have roles in the pathogenesis of the CTS. This is the first study to determine serum periostin levels in CTS patients.
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    Negative correlation between TNF-α and triglyceride levels in patients with cerebral infarction
    (2021) Sacmaci, Hikmet; Cakir, Murat; Sabah Ozcan, Seda
    Aim: To investigate the interactions between tumor necrosis factor-alpha (TNF-α) and blood lipid levels in patients with acute cerebral infarction. Materials and Methods: A total of 43 cerebral infarction patients who applied to the neurology and emergency department of our faculty were included in cross-sectional matched case-control study, and the results were compared with 41 controls who had similar age and comorbidities. In addition to fasting serum lipids, serum glucose, C-reactive protein and hemogram were analyzed as well. Classification of infarct was made. An enzyme-linked immunosorbent test was used to determine baseline plasma TNF-α levels at the time of first admission and potential correlations between the groups were analyzed. Results: Compared to the control group, the cerebral ischemia group had a higher median TNF-α level (23.53; range, 21.74-43.29 ng/L vs. 23.00; range, 20.62-37.34 ng/L); however, the difference was not significant (p > 0.05). Groups were similar regarding blood lipid values (p > 0.05). In the patient group, TNF-α level showed a negative correlation with triglyceride (TG) and TG / HDL cholesterol (HDL-C) (rho= -0.319 p= 0.037 and rho= -0.321 p= 0.036), whereas no significant correlation was determined in the control group (p > 0.05), on the other hand plasma level of TNF-α was positively correlated with the National Health Stroke Scale score (rho = 0.455 p = 0.002). Conclusions: Our cross-sectional study revealed an interaction between decreased TG and TG / HDL-C and a high concentration of TNF-α in cerebral infarction for the first time. The importance of our finding is that it provides useful preliminary information, which is necessary for further research in this field.