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Öğe Awareness of Dental Students Related to COVID-19 and Problems in Distance Education(2021) Toy, Vesile Elif; Sabanci, Arife; Yüksel Kırmızıgül, İnciObjective: In this survey, it was aimed to evaluate the awareness of dental students related to COVID-19 and to define their problems and concerns during distance education. Materials and Methods: A new survey about COVID -19 was conducted. The online survey was sent to the students of seven dental faculties and the study consisted of 1310 students. Results: Gender distribution of the respondents was as 38% male and 62% female. While 24.4% were very worried about getting coronavirus, 78.7% were very worried about transmitting it to their immediate environment. Most of the students (84.7%) knew the 3 most evident symptoms of coronavirus, 90.5% of them were aware of the most important measures to be taken to protect against it. Students who thought that transition to distance education was necessary were afraid of getting infected with COVID-19 at a high rate if formal education will be started again (88.3%). Although 63.5% of the participants stated that theoretical courses given by distance education system were sufficient, only 9.8% of them stated that practical courses were sufficient. Conclusion: Currently challenges related to dental education remain as an important issue to be managed during this pandemic. Dental schools urgently need to improve their education policies and protocols and develop an emergency plan to maintain practical training safely.Öğe The effects of diabetes mellitus on peri-implant marginal bone loss in the posterior maxilla(2019) Uslu, Ozay Mustafa; Karaca, Mustafa; Sabanci, ArifeAbstract: Aim: The aim of this retrospective study was to evaluate the effects of Diabetes Mellitus on peri-implant marginal alveolar bone lossin sinus lifted well-controlled diabetic patients at long term.Materials and Methods: Thirty eight patients with 77 dental implants were included the study. The study consists of 2 groups;control group (C) and diabetes mellitus group (DM). The dental implants were placed after open window maxillary sinus liftingsurgery at maxillary posterior region. After conventional loading process patients were followed periodically for bone loss andclinical parameters. The peri-implant marginal bone loss was assessed at minimum 3 years after functional loading. Standardizedpanoramic radiographs were obtained at the baseline and maintenance which were used for evaluating the marginal bone loss andclinical and anatomical crown to implant ratio. The Student-t test and Mann Whitney-U test were used to analyse any significantdifferences between two groups (p<0.05). The Kruskal Wallis test was used for inter-group comparisons of parameters and Chisquare test, Fisher’s Exact Chi-square test and Continuity (Yates) correction were used to compare qualitative data. Spearman’s rhocorrelation analysis was used to examine the relationships between parameters with non-normal distribution.Results: A total of 77 dental implants were followed up for at least 36 months. The mean follow-up was 43.47±10.30 months. 2implants were failed in DM group. The mean marginal bone loss in DM and C group were 1.35±1.22 mm and 0.91±1 mm respectively.There was no statistically significance in terms of marginal bone loss between the two groups (p>0.05).Conclusion: Within the limitations of this study, it was shown that long-term follow-up results of dental implants in well-controlleddiabetic patients were similar to those of healthy individuals and DM did not increase the peri-implant marginal bone loss.Öğe EVALUATION OF AWARENESS AND CONCERN LEVELS ABOUT COVID-19 PANDEMIC OF PATIENTS WHO ADMIT TO THE FACULTY OF DENTISTRY(2021) Sabanci, Arife; Toy, E.; Kırmızıgül, İnciAbstract: In this research, it was aimed to evaluate the awareness and concerns of patients applying to the faculty of dentistry about the COVID-19 pandemic and to determine their thoughts and concerns about dental treatment during the pandemic period. The questionnaire included questions about personal demographic characteristics, concern, awareness and knowledge level related to COVID-19 disease, and also questioned their need for oral and dental health services and to what extent these needs were met. This cross-sectional survey was conducted on 517 patients. Of the patients, 44.9% knew both the symptoms of COVID-19 and prevention methods of COVID-19. The level of knowledge was higher in; females (64.7%) than males (35.3%), university graduates (57.3%) than middle and high school graduates. Those who were concerned about getting coronavirus had a significantly higher rate of hesitation about coming to dental treatment during this period compared to those who were not concerned (p<0.05). The majority of patients believed that the healthcare facility could prevent coronavirus transmission and 80.5% thought they could be infected from other patients in the waiting room. This study provides us important information about access to safe oral dental health services and the awareness and concern of dental patients.Öğe Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease(Wiley, 2024) Kirmiziguel, Omer Alperen; Sabanci, Arife; Disli, Faruk; Yildiz, Sedat; Milward, Michael R.; Aral, KubraBackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria-endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation. Previously, proteins that have been associated with these MERC contact sites mitofusin-1 (MFN1) and mitofusin-2 (MFN2) have been found to be downregulated in periodontal disease in vitro. Therefore, the aim of the current study was to evaluate MFN1 and MFN2 in gingival crevicular fluid (GCF) of patients with periodontal disease compared with healthy controls clinically. MethodsA total of 48 participants were divided into three groups including periodontally healthy (n = 16), patients with gingivitis (n = 16), and patients with stage 3 grade B periodontitis (n = 16). GCF levels of MFN1, MFN2, calcium (Ca), caspase-1, and tumor necrosis factor-alpha (TNF-& alpha;) were determined via enzyme-linked immunosorbent assay (ELISA). Results were calculated as total amount and concentration. ResultsMFN1 levels (total amount) were significantly higher in patients with periodontitis and gingivitis when compared with healthy controls (p < 0.05). However, concentration levels of MFN1, MFN2, Ca, caspase-1, TNF-& alpha; significantly decreased in periodontal disease groups compared with healthy controls (p < 0.05). A positive correlation was detected among all evaluated markers (p < 0.05). ConclusionThe MERC protein MFN1 may have a role in the pathogenesis of periodontal disease due to its increase in GCF of patients with periodontitis and gingivitis.Öğe Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy(Springer Heidelberg, 2022) Sabanci, Arife; Karasu, Basak; Sabanci, Halil Ibrahim; Kuku, Irfan; Kirmizigul, Omer AlperenObjectives Oral mucositis (OM) is a frequent complication of cancer treatments. Oral mucositis and periodontal disease have a common inflammatory pattern. The purpose of this study was to evaluate the OM and its association with periodontal status in patients with hematologic malignancies who undergo high-dose chemotherapy. Materials and methods Fifty-five patients who received high-dose chemotherapy were included in the study. Full-mouth periodontal clinical measurements including plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD) values were recorded before the condition chemotherapy regime. OM monitoring was initiated 1 day after the chemotherapy and maintained for 20 days. Results Twenty-two of patients (40%) were observed oral mucositis after high-dose chemotherapy. Patients with mucositis had significantly higher GI scores than those who did not have mucositis (p < 0.05). There was a significantly moderate positive correlation between the grade of mucositis and GI scores (p < 0.05). In patients with periodontitis, the incidence of grade 1-2 mucositis was significantly higher than in the healthy group (p < 0.05). In individuals with periodontitis and gingivitis, the healing duration of mucositis was significantly longer than the healthy group (p < 0.05). Conclusions The results of this study showed that the severity grades of oral mucositis may increase in patients with gingival inflammation. The results also suggest that periodontal diseases may have a significant impact on the duration of oral mucositis.Öğe Inflammatory parameters in gingival crevicular fluid and saliva of patients with celiac disease: a comparative analysis(Springer Heidelberg, 2025) Sabanci, Arife; Kirmizigul, Omer Alperen; Ozgen, Nazmi; Sabanci, Halil Ibrahim; Koc, Ahmet; Disli, Faruk; Yildiz, SedatObjective Celiac disease (CD) is an immune-mediated chronic enteropathy that causes chronic inflammation and has been found to cause oral health problems. The aim of this study was to compare the levels of the inflammatory markers calcium (Ca), caspase-1 and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) and saliva of patients with and without celiac disease. Methods A total of 60 participants were divided into two groups: patients with celiac disease on a gluten diet (C) (n = 30) and systemically healthy controls (H) (n = 30). Full-mouth periodontal measurements, including the gingival index (GI), plaque index (PI), bleeding on probing (BOP), and probing depth (PD), were recorded for all participants. Saliva and GCF samples were collected for analysis of the levels of TNF-alpha, Ca, and caspase-1 via enzyme-linked immunosorbent assay (ELISA). Results Salivary and GCF Ca, caspase-1, and TNF-alpha levels were not different between the two groups (p > 0.05). Conclusions Oral inflammatory profiles of celiac disease patients on a gluten-free diet show similarities with systemically healthy individuals.Öğe Oral and post-transplantation infectious status in patients with hematopoietic stem cell transplants: A prospective observational study(Elsevier Science Inc, 2023) Sabanci, Arife; Kuku, IrfanObjective. Infectious status may be life threatening in hematopoietic stem cell transplant (HSCT) recipients. The aim of this study was to evaluate the effect of oral status on infectious conditions during the neutropenic phase after HSCT.Study Design. Seventy patients with various hematologic malignancies were involved. Before HSCT, oral and periodontal exami-nation, including the number of teeth and decayed, missing, and filled teeth index (DMFT); visible plaque (%); bleeding on prob-ing (BOP [%]); clinical attachment level; and probing depth (PD) values were collected. Daily blood cultures were collected and analyzed in terms of infection-related parameters, including febrile neutropenia (FN), bacteremia, and C-reactive protein (CRP) during the neutropenic phase of HSCT.Results. Forty-two patients (60%) received autologous and 28 (40%) allogeneic HSCT. In both groups, patients without FN after HSCT had significantly lower DMFT index scores and fewer sites with PD >4 mm (P < .05). However, bacteremia, FN, and CRP were similar in patients with periodontitis compared with non-periodontitis patients (P > .05).Conclusions. The results suggest that periodontal status may not significantly impact the infection-related parameters in patients treated for HSCT. However, DMFT and the prevalence of sites with PD >4 mm may be involved in febrile neutropenia. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;135:242-248)Öğe Resonance frequency analysis of dental implants in patients with vitamin D deficiency(Springer Heidelberg, 2024) Toy, Vesile Elif; Sabanci, ArifeObjectives Vitamin D deficiency may influence dental implant osseointegration unfavourably. The aim of this study was to compare dental implant stabilities of patients with different levels of vitamin D and investigate the effects of vitamin D supplementation. Materials and methods One hundred and twenty-nine patients who underwent dental implantation were grouped regarding vitamin D levels and supplement use: Group A; vitamin D deficiency and supplement usage, Group B; insufficiency with supplement usage, Group C; insufficiency without supplements and Group D; vitamin D sufficiency. Resonance frequency analysis (RFA) measurements were performed at baseline and 3 months. Patients with vitamin D deficiency (Group A) and insufficiency (Group B) were prescribed supplements by specialists. Pearson correlation analysis was used to examine an association between vitamin D levels and implant stability. Results Primary stability of Group D (76.34 +/- 6.55) was significantly higher than Groups A, B and C at baseline (p < 0.05). At 3 months, Group C scored significantly lower than the other groups (p < 0.05). The results revealed a correlation between serum levels of vitamin D and RFA measurements at 3 months (p < 0.05). Conclusion It was observed that high vitamin D levels influenced implant stabilities positively, as evidenced by higher Implant Stability Quotient values. Low levels of vitamin D may be associated with a decrease in implant stability. Statement of Clinical Relevance Vitamin D, concerning its impact on bone metabolism, is currently of particular interest in implant dentistry. The lower stability scores in patients with vitamin D deficiency reinforce the recommendation of Vitamin D supplementation when treating those patients with dental implants.Öğe Vitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-Implant Tissues: A Case-Control Study(Wiley, 2025) Toy, Vesile Elif; Sabanci, Arife; Dundar, Muhammed; Disli, Faruk; Yildiz, Sedat; Aral, KubraObjectives Vitamin D has been reported to be crucial for bone mineralization and to play a significant role in immune and inflammatory responses. Its deficiency has been stated to be highly prevalent and might alter osseointegration of dental implants. Successful osseointegration has been claimed to be a critical aspect of implant survival and the effects of vitamin D on implant osseointegration have not been well documented. This study aimed to evaluate bone markers and cytokine levels of patients with or without vitamin D insufficiency. Material and Methods A total of 42 patients were included and divided into two groups: vitamin D insufficient (Group IN-S; n = 21) and vitamin D sufficient (Group S; n = 21). Besides clinical periodontal parameters and implant stability measurements, the levels of RANKL, OPG, osteocalcin (OC), calcium (Ca), tumor necrosis factor alpha (TNF-alpha), IL-1 beta, caspase-1 (CASP1), and IL-10 in bone biopsy from implant preparation sockets and peri-implant crevicular fluid (PICF) were determined by enzyme-linked immunosorbent assay (ELISA). The results were represented as concentration and total amount. Results PICF RANKL levels (both concentration and total amount) were higher in patients with Vitamin D insufficiency compared to sufficient controls (p < 0.05). Concentration and total amount of IL-10 were significantly lower in vitamin D insufficient participants than those of vitamin D sufficient group (p < 0.05). No differences were detected between the groups in terms of other parameters. Bone levels of all evaluated parameters also did not differ between the groups (p > 0.05). Conclusion It may be concluded that a low serum level of vitamin D may affect peri-implant health through altering IL-10 and RANKL.
