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    Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy
    (Springer Heidelberg, 2022) Sabanci, Arife; Karasu, Basak; Sabanci, Halil Ibrahim; Kuku, Irfan; Kirmizigul, Omer Alperen
    Objectives Oral mucositis (OM) is a frequent complication of cancer treatments. Oral mucositis and periodontal disease have a common inflammatory pattern. The purpose of this study was to evaluate the OM and its association with periodontal status in patients with hematologic malignancies who undergo high-dose chemotherapy. Materials and methods Fifty-five patients who received high-dose chemotherapy were included in the study. Full-mouth periodontal clinical measurements including plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD) values were recorded before the condition chemotherapy regime. OM monitoring was initiated 1 day after the chemotherapy and maintained for 20 days. Results Twenty-two of patients (40%) were observed oral mucositis after high-dose chemotherapy. Patients with mucositis had significantly higher GI scores than those who did not have mucositis (p < 0.05). There was a significantly moderate positive correlation between the grade of mucositis and GI scores (p < 0.05). In patients with periodontitis, the incidence of grade 1-2 mucositis was significantly higher than in the healthy group (p < 0.05). In individuals with periodontitis and gingivitis, the healing duration of mucositis was significantly longer than the healthy group (p < 0.05). Conclusions The results of this study showed that the severity grades of oral mucositis may increase in patients with gingival inflammation. The results also suggest that periodontal diseases may have a significant impact on the duration of oral mucositis.
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    Inflammatory parameters in gingival crevicular fluid and saliva of patients with celiac disease: a comparative analysis
    (Springer Heidelberg, 2025) Sabanci, Arife; Kirmizigul, Omer Alperen; Ozgen, Nazmi; Sabanci, Halil Ibrahim; Koc, Ahmet; Disli, Faruk; Yildiz, Sedat
    Objective Celiac disease (CD) is an immune-mediated chronic enteropathy that causes chronic inflammation and has been found to cause oral health problems. The aim of this study was to compare the levels of the inflammatory markers calcium (Ca), caspase-1 and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) and saliva of patients with and without celiac disease. Methods A total of 60 participants were divided into two groups: patients with celiac disease on a gluten diet (C) (n = 30) and systemically healthy controls (H) (n = 30). Full-mouth periodontal measurements, including the gingival index (GI), plaque index (PI), bleeding on probing (BOP), and probing depth (PD), were recorded for all participants. Saliva and GCF samples were collected for analysis of the levels of TNF-alpha, Ca, and caspase-1 via enzyme-linked immunosorbent assay (ELISA). Results Salivary and GCF Ca, caspase-1, and TNF-alpha levels were not different between the two groups (p > 0.05). Conclusions Oral inflammatory profiles of celiac disease patients on a gluten-free diet show similarities with systemically healthy individuals.