Yazar "Sacmaci, Hikmet" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Decreased serum periostin level is associated with carpal tunnel syndrome
    (2020) Sabah Ozcan, Seda; Sacmaci, Hikmet; Cakir, Murat
    Aim: Noninflammatory subsynovial connective tissue (SSCT) fibrosis with nerve compression is an obvious feature of carpal tunnel syndrome (CTS). We investigated serum levels of periostin, which is known to have an effect on fibrosis, in patients with CTS. Material and Methods: A total of 39 healthy individuals and 32 patients who were newly diagnosed with CTS were included in this prospective clinical study. Duration of symptoms, severity, unilateral or bilateral side of CTS diagnosis of patients were recorded. Serum samples were received for the measurement of periostin levels from all participants and were analyzed using commercial enzyme-linked immunosorbent assay (ELISA) kits. Results: Serum periostin levels were significantly lower in CTS patients than controls (p=0.030). Additionally, there was no correlation between serum periostin levels and CTS disease regarding the duration of symptoms and electrophysiological severity of symptoms (p > 0.05).Conclusion: In the current study, it was evaluated that there is a significant relation between CTS and serum periostin levels. Periostin may have roles in the pathogenesis of the CTS. This is the first study to determine serum periostin levels in CTS patients.
  • Küçük Resim
    Öğe
    Negative correlation between TNF-α and triglyceride levels in patients with cerebral infarction
    (2021) Sacmaci, Hikmet; Cakir, Murat; Sabah Ozcan, Seda
    Aim: To investigate the interactions between tumor necrosis factor-alpha (TNF-α) and blood lipid levels in patients with acute cerebral infarction. Materials and Methods: A total of 43 cerebral infarction patients who applied to the neurology and emergency department of our faculty were included in cross-sectional matched case-control study, and the results were compared with 41 controls who had similar age and comorbidities. In addition to fasting serum lipids, serum glucose, C-reactive protein and hemogram were analyzed as well. Classification of infarct was made. An enzyme-linked immunosorbent test was used to determine baseline plasma TNF-α levels at the time of first admission and potential correlations between the groups were analyzed. Results: Compared to the control group, the cerebral ischemia group had a higher median TNF-α level (23.53; range, 21.74-43.29 ng/L vs. 23.00; range, 20.62-37.34 ng/L); however, the difference was not significant (p > 0.05). Groups were similar regarding blood lipid values (p > 0.05). In the patient group, TNF-α level showed a negative correlation with triglyceride (TG) and TG / HDL cholesterol (HDL-C) (rho= -0.319 p= 0.037 and rho= -0.321 p= 0.036), whereas no significant correlation was determined in the control group (p > 0.05), on the other hand plasma level of TNF-α was positively correlated with the National Health Stroke Scale score (rho = 0.455 p = 0.002). Conclusions: Our cross-sectional study revealed an interaction between decreased TG and TG / HDL-C and a high concentration of TNF-α in cerebral infarction for the first time. The importance of our finding is that it provides useful preliminary information, which is necessary for further research in this field.