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    Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2015) Sahin, Levent; Sahin, Hilal; Karahan, Feride; Gul, Semir; Bahar, Leyla; Gul, Mehmet; Ozaksit, Muzeyyen Gulnur
    We investigated the effects of a caerulein-induced acute pancreatitis (AP) on uterus and possible uterine protective effects of melatonin administration. Twenty-eight animals were divided into four groups: (1) control group (n = 7); (2) melatonin group (n = 7); (3) caerulein group (n = 7); (4) melatonin + caerulein group (n = 7). AP was induced by 4 intraperitoneal injection of caerulein given hourly (50 mu g/kg) into young female animals. Melatonin (20 mg/kg) was given via intraperitoneal injection 30 min prior to the induction of AP. The rats were sacrificed by decapitation 12 h after the last injection of caerulein and their uterus were taken for histopathological evaluation. Mean body weight and uterine wet weight was recorded. The H-Score method was used to score the degree of histological changes of endo-myometrium edema, hemorrhage, necrosis, leucocyte infiltration, endometrial proliferation and endometrial thickness. There was no significant difference in the mean body weight observed after treatment in each group. The uterine wet weight differences between the control and caerulein given rats were significant (P < 0.01). The endometrial thickness, edema, hemorrhage, necrosis and leucocyte infiltration of the caerulein group was significantly higher than the control and melatonin groups (P < 0.01). It was observed that preteratment with melatonin normalized histological abnormalities and significantly reduced uterine wet weight as compared with the caerulein only group. Melatonin application may play an important role in the prophylaxis of uterine endometrium arising from adverse effects of caerulein.
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    The Effect of Ceftriaxone on Testicular Connexin 43 Expression.
    (Sage Publications Inc, 2016) Sahin, Levent; Sahin, Hilal; Vardi, Nigar; Karahan, Feride; Yildiz, Azibe; Taslidere, Elif; Gul, Semir
    [Abstract Not Available]
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    Is preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?
    (Elsevier Taiwan, 2014) Sahin, Levent; Bozkurt, Murat; Sahin, Hilal; Gurel, Aykut; Yumru, Ayse Ender
    To select cytogenetically normal embryos, preimplantation genetic diagnosis (PGD) aneuploidy screening (AS) is used in numerous centers around the world. Chromosomal abnormalities lead to developmental problems, implantation failure, and early abortion of embryos. The usefulness of PGD in identifying single-gene diseases, human leukocyte antigen typing, X-linked diseases, and specific genetic diseases is well-known. In this review, preimplantation embryo genetics, PGD research studies, and the European Society of Human Reproduction and Embryology PGD Consortium studies and reports are examined. In addition, criteria for embryo selection, technical aspects of PGD-AS, and potential noninvasive embryo selection methods are described. Indications for PGD and possible causes of discordant PGD results between the centers are discussed. The limitations of fluorescence in situ hybridization, and the advantages of the array comparative genomic hybridization are included in this review. Although PGD-AS for patients of advanced maternal age has been shown to improve in vitro fertilization outcomes in some studies, to our knowledge, there is not sufficient evidence to use advanced maternal age as the sole indication for PGD-AS. PGD-AS might be harmful and may not increase the success rates of in vitro fertilization. At the same time PGD, is not recommended for recurrent implantation failure and unexplained recurrent pregnancy loss. Copyright (C) 2014, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.