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Öğe The comparison of serum interleukin, growth factor and lactoferrin levels in the primary and reactive thrombocytosis(Blackwell Science Ltd, 1998) Seçkin, Y; Sahin, K; Sari, R; Hartputluoglu, MM; Aydogdu, I; Sevinç, A; Yologlu, S[Abstract Not Available]Öğe The evaluation of serum cytokine levels in febrile neutropenic patients(Blackwell Science Ltd, 1998) Seçkin, Y; Sahin, K; Harputluoglu, MM; San, R; Türk, HM; Sevinç, A; Aydogdu, I[Abstract Not Available]Öğe False-positive reaction between syphilis and hepatitis C infection(Israel Journal Med Sciences, 1997) Sonmez, E; Ozerol, IH; Senol, M; Kizilkaya, N; Sahin, K; Ozbilge, HThere are limited data about false-positive reactions against hepatitis C virus (HCV) in syphilitic patients and false-positive reactions against syphilis in the patients with HCV infection, The aim of this study was to demonstrate the false-positivity of syphilis in patients with HCV infection, the false-positivity of anti-HCV in patients with syphilis and the validity of the serological tests in such patients. Fifty patients with positive anti-HCV, 21 patients with positive VDRL and 50 healthy subjects were studied. Syphilis serology was determined by the Venereal Disease Research Laboratory (VDRL) test and microhemagglutination for T. pallidum (MHA-TP) test. Hepatitis C serology was determined by a second generation ELISA (Ortho Diagnostics) test for HCV antibody, and anti-HCV positive patients were tested for HCV RNA by polymerase chain reaction (PCR). All assays were performed on all subjects. Not only the false-positive VDRL reaction in the patients with HCV infection but also false-positive anti-HCV tests in syphilitic patients have been observed. Four patients with syphilis had positive anti-HCV and negative HCV-RNA, whereas 10% (5 of 50) of patients with hepatitis C infection had positive VDRL and these patients were negative for MHA-TP test, The rates of false-positivity of VDRL and anti-HCV were higher than within the control group (p<0.05). According to these data, positive anti-HCV in syphilitic patients and positive VDRL in chronic hepatitis C may be false-positive results with regard to the reaginic tests, Therefore, therapeutic measures should not be initiated without confirmation with a treponemal test or PCR. VDRL and HCV-ELISA tests may be interacted with IgM or IgG antibodies. This relationship should be investigated in further studies.Öğe Methicillin-resistance among Turkish isolates of Staphylococcus aureus strains from nosocomial and community infections and their resistance patterns using various antimicrobial agents(W B Saunders Co Ltd, 1997) Durmaz, B; Durmaz, R; Sahin, KThe purposes of this study were to determine the prevalence of Turkish isolates of methicillin-resistant Staphylococcus aureus (MRSA) in nosocomial and community infections and their antibiotic resistant patterns. The oxacillin disk diffusion method for the detection of methicillin resistance and the Kirby-Bauer disk diffusion for antibiotic susceptibility tests were used. A total 383 S. aureus strains were identified from different patients. The prevalence of methicillin resistance among S. aureus strains was 31.3% (120/383). The proportions of MRSA isolated from nosocomial and community infections were 26.4% (46/174) and 35.4% (74/209), respectively. The resistance rates of MRSA to other antibiotics were as follows: 71% resistant to erythromycin, 54% to clindamycin, 52% to gentamicin, 44.5% to trimethoprim-sulfamethoxazole and 36% to ciprofloxacin. No strain resistant to vancomycin was recorded in this study.Öğe Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's disease(Bmj Publishing Group, 2002) Er, H; Evereklioglu, C; Cumurcu, T; Türköz, Y; Özerol, E; Sahin, K; Doganay, SBackground/aims: Beligei's disease (BD) is a systemic inflammatory vasculitis of young adults with unknown aetiology, characterised by endothelial dysfunction and occlusion in both deep venous and retinal circulation. Ocular involvement occurs in 70% of cases and is characterised by periphlebitis, periarteritis, vascular occlusion, and thrombosis leading to blindness despite vigorous treatment. Endothelin-1 (ET-1) is a vasoconstricting peptide while nitric oxide (NO) is a relaxing molecule and both are released by endothelium for blood flow regulation. Homocysteinaemia is a newly defined term connected to the increased risk of atherothrombotic and atherosclerotic systemic and retinal vascular occlusive diseases, and its role in the course of BID has not been previously described. The authors aimed to detect serum total homocysteine (tHcy), ET-1, and NO in BID and to assess if tHcy, ET-1, and NO are associated with ocular BD or disease activity. Methods: 43 consecutive patients with ocular (n = 27) or non-ocular (n = 16) BD (36.95 (SD 9.80) years, 22 male, 21 female) satisfying international criteria, and 25 age and sex matched healthy control subjects (37.88 (8.73) years, 13 male, 12 female) without a history of systemic or retinal venous thrombosis were included in this study. Patients were examined by two ophthalmologists with an interest in BID. Serum tHcy, ET-1, and NO concentrations were measured in both groups. Hype rhomocysteinaemia was defined as a tHcy level above the 95th percentile in the control group. Patients were divided into active and inactive period by acute phase reactants including (X, antitrypsin, alpha(2), macroglobulin, erythrocyte sedimentation rate, and neutrophil count. Results: The overall mean serum tHcy, ET-1, and NO levels were significantly higher in patients with BD than in control subjects (tHcy = 15,83 (4.44) v7.96 (2.66) ng/ml, p <0.001; ET-1 = 17.47 (4.33) v 5.74 (2.34) mumol/ml, p <0.001; NO = 37.60 (10.31) v 27.08 (7.76) mumol/l, p <0.00 1). Serum I tHcy, ET-1, and NO levels were significantly higher in active patients than in inactive patients and control subjects. In addition, among patients with ocular BID, the mean tHcy levels were significantly increased and correlated with ET-1 and NO levels when compared with non-ocular disease and control subjects. All acute phase reactant levels were significantly higher in active period than in inactive stage and controls. Conclusions: Elevated tHcy may be responsible for the endothelial damage in BD and may be an additional risk Factor for the development of retinal vascular occlusive disease, contributing to the poor visual outcome in these patients. Assessment of tHcy may be important in the investigation and management of patients with BD, especially with ocular disease.Öğe Urinary excretion of deoxypyridinoline in 24-hour and first-void samples in healthy Turkish children(Pergamon-Elsevier Science Ltd, 2000) Soylu, H; Aras, S; Kutlu, NO; Egri, M; Sahin, KObjectives: Collagen cross-links are formed during the maturation process of bone matrix. They have been considered as valuable markers in some metabolic, endocrinologic, and neoplastic bone disorders. As an advantage, it can be measured in urine as well as in serum samples. However, the excretion characteristics remains controversial. Design and methods: We investigated urinary free deoxypyridinoline (f-Dpd) excretion in first-void urine samples and in 24-hour collections in healthy Turkish children. We also evaluated the possible correlations and gender-related differences in Dpd excretion between these sampling methods. Both urine samples of 62 subjects (aged from 31 to 120 months) were analyzed by Immulite chemiluminescent technique. Results: There were no remarkable differences in f-Dpd excretion between first-void and 24-hour urine samples, although f-Dpd values of the first-void samples were slightly higher (Dpd: creatinine, mean +/- SD, 20.5 +/-; 5.8 nmol/mmol vs. 19.6 +/- 5.6 nmol/mmol, respectively, p > 0.05), A strong linear correlation was found between 24-hour and first-void urine f-Dpd excretions (r = 0.77, p < 0.05). In addition, f-Dpd showed no gender-related differences between boys and girls in either 24-hour or first-void urine samples (p > 0.05). Conclusions: Because of difficulties in long-time urine collection in infants and young children, f-Dpd assessment in first-void single urine samples is an easy, safe, and non-invasive method. Copyright (C) 2000 The Canadian Society of Clinical Chemists.
