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Öğe Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?(Kafkas Univ, Veteriner Fakultesi Dergisi, 2015) Sahin, Levent; Sahin, Hilal; Karahan, Feride; Gul, Semir; Bahar, Leyla; Gul, Mehmet; Ozaksit, Muzeyyen GulnurWe investigated the effects of a caerulein-induced acute pancreatitis (AP) on uterus and possible uterine protective effects of melatonin administration. Twenty-eight animals were divided into four groups: (1) control group (n = 7); (2) melatonin group (n = 7); (3) caerulein group (n = 7); (4) melatonin + caerulein group (n = 7). AP was induced by 4 intraperitoneal injection of caerulein given hourly (50 mu g/kg) into young female animals. Melatonin (20 mg/kg) was given via intraperitoneal injection 30 min prior to the induction of AP. The rats were sacrificed by decapitation 12 h after the last injection of caerulein and their uterus were taken for histopathological evaluation. Mean body weight and uterine wet weight was recorded. The H-Score method was used to score the degree of histological changes of endo-myometrium edema, hemorrhage, necrosis, leucocyte infiltration, endometrial proliferation and endometrial thickness. There was no significant difference in the mean body weight observed after treatment in each group. The uterine wet weight differences between the control and caerulein given rats were significant (P < 0.01). The endometrial thickness, edema, hemorrhage, necrosis and leucocyte infiltration of the caerulein group was significantly higher than the control and melatonin groups (P < 0.01). It was observed that preteratment with melatonin normalized histological abnormalities and significantly reduced uterine wet weight as compared with the caerulein only group. Melatonin application may play an important role in the prophylaxis of uterine endometrium arising from adverse effects of caerulein.Öğe The Effect of Ceftriaxone on Testicular Connexin 43 Expression.(Sage Publications Inc, 2016) Sahin, Levent; Sahin, Hilal; Vardi, Nigar; Karahan, Feride; Yildiz, Azibe; Taslidere, Elif; Gul, Semir[Abstract Not Available]Öğe THE EFFECTS OF VINPOCETINE ON THE PREVENTION AND TREATMENT OF THE ISCHEMIA/REPERFUSION INJURY: AN EXPERIMENTAL STUDY(Carbone Editore, 2017) Sahin, Levent; Sarihan, M. Ediz; Parlakpinar, Hakan; Polat, Alaadin; Vardi, NigarObject: Histopathological and biochemical effects of vinpocetine, which is an anti-inflammatory and antioxidant agent, on ischemia / reperfusion (I/R) injury were studied in an animal model. Material and methods: Forty Sprague Dawley rats were divided into five groups. Group1 underwent only a right nephrectomy. Group 2 was administrated vinpocetine after right nephrectomy. Group 3 initially underwent a right nephrectomy. Them, left kidney of this group was applied ischemia for 60 minutes, which was followed by reperfusion for 24 hours. Group 4 underwent same steps as group 3; but was administrated vinpocetine 10 mg/kg i.p. before I/R to the left kidney. Similarly, group 5 underwent same steps as group 3 but was administrated vinpocetine 10 mg/kg i.p. after I/R to the left kidney. Results: Plasma BUN and creatinine showed no significant differences between control ( Sham) group and groups that were administrated vinpocetine. Decrease in plasma urea and creatinine was detected group 5, but this finding was not present in group 4. Superoxide dismutase and glutathione reductase levels in groups 4 and 5 were significantly higher than the group 3. Parallel to this, oxidative stress index was higher in the group 3compared to groups 2, 4, and 5 (p<0.05). No significant difference was found between levels of malondialdehite in sham and vinpocetine administrated only group (p<0.005). All groups showed no differences in catalase levels and Total Antioxidant Capacity. Decreased tubular injury was present in the groups administrated vinpocetine before and after I/R. In control and vinpocetine given groups, there were some apoptosis in tubules after tested with caspase 3. Caspase 3 positivity was significantly higher in I/R group compared to control group. Vinpocetine if given after I/R was more effective to prevent apoptosis then to be administrated before I/R. Conclusion: This experimental study showed that vinpocetine promotes achieving better renal functions. The results of this study suggest that vinpocetine may be used in the treatment of renal I/RÖğe An investigation of extremity injuries in school-aged children presenting to the emergency department(2020) Ekmekyapar, Muhammed; Sahin, LeventAim: It was aimed that various preventive measures should be taken with the demographic characteristics, trauma etiology, injury sites and radiological imaging results of school-age pediatric patients admitted to the emergency department after isolated extremity trauma.Material and Methods: In our two-center study, 748 patients with isolated limb injuries aged 6-17 years were prospectively evaluated. Their gender, age, causes of trauma, requested radiological imaging in patients classified according to injury sites, treatments, requested consultations, hospitalization and discharge rates were examined.Results: The mean age was 12.2 ± 3.2 years. The most common cause of injury (52.8%) was fall while playing. Fall while playing (FWP) and extremity injuries occurring during sport were more in males than females (p = 0.020). When injury sites were compared according to trauma etiologies, injuries were observed mostly in the left upper extremity in FWPs and mostly in the right upper extremity in school accidents (p = 0.009). An orthopedic consultation request was high in patients who underwent splinting and surgical treatment (p = 0.000). While fracture was detected in 136 (18.1%) patients included in the study, splint or Velpeau bandage treatments were applied to 314 (41.9%) patients. Conclusion: In school-aged child injuries, the most common cause was observed to be "fall," which is a preventable cause. Protective measures that will be taken for the safety of children at home, playgrounds, and schools can reduce these injuries.Öğe Is preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?(Elsevier Taiwan, 2014) Sahin, Levent; Bozkurt, Murat; Sahin, Hilal; Gurel, Aykut; Yumru, Ayse EnderTo select cytogenetically normal embryos, preimplantation genetic diagnosis (PGD) aneuploidy screening (AS) is used in numerous centers around the world. Chromosomal abnormalities lead to developmental problems, implantation failure, and early abortion of embryos. The usefulness of PGD in identifying single-gene diseases, human leukocyte antigen typing, X-linked diseases, and specific genetic diseases is well-known. In this review, preimplantation embryo genetics, PGD research studies, and the European Society of Human Reproduction and Embryology PGD Consortium studies and reports are examined. In addition, criteria for embryo selection, technical aspects of PGD-AS, and potential noninvasive embryo selection methods are described. Indications for PGD and possible causes of discordant PGD results between the centers are discussed. The limitations of fluorescence in situ hybridization, and the advantages of the array comparative genomic hybridization are included in this review. Although PGD-AS for patients of advanced maternal age has been shown to improve in vitro fertilization outcomes in some studies, to our knowledge, there is not sufficient evidence to use advanced maternal age as the sole indication for PGD-AS. PGD-AS might be harmful and may not increase the success rates of in vitro fertilization. At the same time PGD, is not recommended for recurrent implantation failure and unexplained recurrent pregnancy loss. Copyright (C) 2014, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Serum salusins levels are increased and correlated positively with cyst size in ovarian endometrioma(Taylor & Francis Ltd, 2015) Sahin, Levent; Bozkurt, Murat; Celik, Onder; Celik, Nilufer; Aydin, Suleyman; Gencdal, ServetObjectives: The objective of this study is to evaluate plasma concentrations of salusin-alpha and salusin-beta levels in women with endometrioma and non-endometriotic benign ovarian cysts. Method: Endometrioma patients (n = 14), non-endometriotic ovarian cysts (n = 14), and age-matched normal healthy fertile subjects (n = 14) participated in this study. Plasma salusin-alpha and salusin-beta levels at the time of mid-luteal phase before and 3 months after L/S cystectomy were measured using ELISA and EIA tests, and their relation with demographic parameters was also assessed. Results: The mean salusin-alpha and salusin-beta levels were significantly higher in women with endometrioma before the removal of cyst compared with cases with non-endometriotic cyst and fertile cases. Surgical removal of the endometrioma decreased the mean salusin-alpha and salusin-beta levels to the level of those with non-endometriotic cyst before and after the cystectomy and fertile women, in both unilateral and bilateral endometrioma cases. Plasma salusin-beta concentrations were found to be positively correlated with age, size of cyst, bilaterality, and salusin-alpha levels. Salusin-beta values showed no correlations to BMI and size of the ovarian cysts. Conclusions: Plasma salusin-alpha and salusin-beta levels are increased in endometrioma patients and positively correlated with endometrioma size. Laparoscopic removal of the endometrioma by stripping technique decreases the salusin levels to a similar level of fertile women.
