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Öğe ASSOCIATION BETWEEN HLA CLASS II ALLELES AND MORBID OBESITY Basic science and research in bariatric surgery(Springer, 2019) Ozmen, F.; Ergen, G. O.; Sahin, T. T.; Ozmen, M. M.[Abstract Not Available]Öğe Comment on: Prevention of biliary fistula after partial hepatectomy by transcystic biliary drainage: randomized clinical trial(Oxford Univ Press, 2020) Akbulut, S.; Sahin, T. T.; Yilmaz, S.[Abstract Not Available]Öğe Early Hepatic Artery Thrombosis After Pediatric Living Donor Liver Transplantation(Elsevier Science Inc, 2019) Kutluturk, K.; Sahin, T. T.; Karakas, S.; Unal, B.; Bag, H. G. Gozukara; Akbulut, S.; Aydin, C.Aim. Hepatic artery thrombosis is one of the major complications affecting patient and graft survival after liver transplantation. In this study, we analyzed the factors affecting the development of early hepatic artery thrombosis (eHAT) and its outcomes in pediatric liver transplantation. Methods. A total of 175 pediatric patients underwent living donor liver transplantation between January 2013 and November 2018. Factors affecting eHAT and its outcomes were examined. Results. Nine patients (5.1%) developed eHAT. In multivariate analysis, intraoperative hepatic artery revision and Roux-en-Y hepaticojejunostomy biliary reconstruction type were statistically significant (all, P < .05). Thrombectomy and reanastomosis was performed in 5 patients. Two of them were successful. In total, 3 retransplantations were performed and all of those patients are still alive. Conclusion. The factors affecting eHAT are still a matter of debate. Intraoperative hepatic artery anastomosis revision and Roux-en-Y hepaticojejunostomy reconstruction were independent risk factors for development of eHAT. In the present study, the confidence interval of the variables is high, therefore exact determination of the risk factors may not be possible. Early detection and thrombectomy and reanastomosis may be the first treatment of choice to rescue the patient and graft. When it fails, retransplantation must be an alternative. The results of the present study state that at least once a day the vascular anastomosis must be examined by Doppler ultrasonography in the post-transplant first week. It must be repeated when liver enzymes increase. The patients under high risk for eHAT may be followed up closer.Öğe In vitro effects of neopterin on invasion, metastasis and proliferation of hepatocellular cancer cell lines(Lippincott Williams & Wilkins, 2023) Satilmis, B.; Sahin, T. T.; Otan, E.; Kutluturk, K.; Karakas, S.; Yilmaz, S.[Abstract Not Available]Öğe The incidence and risk factors for persistent unconsciousness following liver transplantation for acute liver failure(Lippincott Williams & Wilkins, 2019) Sarici, K. B.; Otan, E.; Ince, V; Sahin, T. T.; Karakas, S.; Saglam, K.; Aydin, C.[Abstract Not Available]Öğe Liver paired exchange transplantation: overcoming the obstacles in living donor liver transplantation(Lippincott Williams & Wilkins, 2023) Sahin, T. T.; Yilmaz, S.; Emre, S.; Kutluturk, K.; Karakas, S.; Otan, E.; Cicek, E.[Abstract Not Available]Öğe New and different expanded criteria for liver transplantation in hepatocellular carcinoma: Malatya criteria(Lippincott Williams & Wilkins, 2019) Ince, V; Akbulut, S.; Otan, E.; Ersan, V; Karakas, S.; Sahin, T. T.; Baskiran, A.[Abstract Not Available]Öğe Significance and Outcome of Living-donor Liver Transplantation in Acute Mushroom Intoxication(Wolters Kluwer Medknow Publications, 2018) Baskiran, A.; Dirican, A.; Ozgor, D.; Kement, M.; Koc, S.; Sahin, T. T.; Ates, M.Introduction: Mushroom intoxication ( MT) can lead to acute liver injury which may result in Mushroom intoxication-related liver failure ( M-ALF) requiring liver transplantation ( LT). In the present study, we want to share the experience of our institute regarding living-donor LT ( LDLT) due to mushroom poisoning. Aim: The aim of this study is to identify the predictors of poor prognosis in patients with ALF secondary to mushroom intoxication requiring LDLT. Materials and Methods: All patients with MT between 2008 and 2016 were evaluated. Demographics, symptoms, interval between symptoms and admission to our institute, laboratory data, model for end-stage liver disease ( MELD)/ pediatric end-stage liver disease ( PELD) scores, clinical course, and outcomes of supportive therapy and LT were evaluated. There were two groups in the study: Group A = responsive to supportive therapy ( n = 9) versus Group B = unresponsive to supportive therapy ( n = 9). Results: During the study, a total of 18 patients were admitted with M-ALF. Twelve ( 66.7%) of them were female, and the mean age was 39.9 +/- 18.2 years. All of the nine patients in Group A fully recovered with supportive therapy. In Group B, one patient died during waiting period for LT and 8 patients received LDLT LDLT. Three of the eight patients who were transplanted died in the postoperative early period within postoperative 5 days. The patients in Group B had significantly higher MELD/ PELD scores and encephalopathy rate than in Group A ( P < 0.05). International normalized ratio ( INR), bilirubin, ammonium levels, and platelet count were significantly different between groups ( P < 0.05). The patients in Group B had significantly longer interval before admission to our institute ( P < 0.05). Conclusion: The presence of encephalopathy, higher MELD/ PELD, INR, bilirubin, ammonium levels, and lower platelet count was related to poor prognosis in MT. LDLT provides a good therapeutic option in patients with M-ALF. The time is a crucial factor in successful treatment of MT. Early admission to a tertiary referral center with expertise in LT results in a better prognosis and increased survival following M-ALF.
