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Öğe Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis(Baishideng Publishing Group Inc, 2022) Satilmis, Basri; Cicek, Gizem Selen; Cicek, Egemen; Akbulut, Sami; Sahin, Tevfik Tolga; Yilmaz, SezaiDetermination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved. Adipose-derived mesenchymal stem cells (AD-MSC) are easily isolated and cultured for a long time before losing their stem cell characteristics, which are self-renewal and pluripotency. AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics. They are easily accessible, and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells. It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression. These advantages have popularized its use in many fields including plastic reconstructive surgery. However, in the field of hepatology and liver transplantation, the progress is slower. AD-MSC have the potential to modulate inflammation, ameliorate ischemia-reperfusion injury, and support liver and biliary tract regeneration. These are very important for the treatment of various hepatobiliary diseases. Furthermore, the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis. We need alternative therapeutic approaches to treat end-stage liver failure. AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation. Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis.Öğe Assessment of Liver Regeneration in Patients Who Have Undergone Living Donor Hepatectomy for Living Donor Liver Transplantation(Mdpi, 2023) Satilmis, Basri; Akbulut, Sami; Sahin, Tevfik Tolga; Dalda, Yasin; Tuncer, Adem; Kucukakcali, Zeynep; Ogut, ZekiBackground: Inflammation and the associated immune pathways are among the most important factors in liver regeneration after living donor hepatectomy. Various biomarkers, especially liver function tests, are used to show liver regeneration. The aim of this study was to evaluate the course of liver regeneration following donor hepatectomy (LDH) by routine and regeneration-related biomarkers. Method: Data from 63 living liver donors (LLDs) who underwent LDH in Inonu University Liver Transplant Institute were prospectively analyzed. Serum samples were obtained on the preoperative day and postoperative days (POD) 1, 3, 5, 10, and 21. Regenerative markers including alfa-fetoprotein (AFP), des carboxy prothrombin (DCP), ornithine decarboxylase (ODC), retinol-binding protein 4 (RBP4), and angiotensin-converting enzyme isotype II (ACEII) and liver function tests including alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and total bilirubin levels were all analyzed. Results: The median age of the LLDs was 29.7 years and 28 LLDs were female. Eight LLDs developed postoperative complications requiring relaparotomy. The routine laboratory parameters including AST (<0.001), ALT (<0.001), ALP (<0.001), and total bilirubin (<0.001) showed a significant increase over time until postoperative day (POD) 3. For the regeneration-related parameters, except for the RBP4, all parameters including ACEII (p = 0.006), AFP (p = 0.002), DCP (p = 0.007), and ODC (p = 0.002) showed a significant increase in POD3. The regeneration parameters showed a different pattern of change. In right-lobe liver grafts, ACEII (p = 0.002), AFP (p = 0.035), and ODC (p = 0.001) showed a significant increase over time. DCP (p = 0.129) and RBP4 (p = 0.335) showed no significant changes in right-lobe liver grafts. Conclusions: Regenerative markers are increased in a sustained fashion following LDH. This is more prominent following right-lobe grafts which are indicative of progenitor-associated liver regeneration.Öğe Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature(Baishideng Publishing Group Inc, 2018) Akbulut, Sami; Cicek, Egemen; Kolu, Mehmet; Sahin, Tevfik Tolga; Yilmaz, SezaiAlveolar echinococcosis (AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins (R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for margin-negative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery.Öğe Comment on a new treatment strategy for end-stage hepatic alveolar echinococcosis: IVC resection without reconstruction(Elsevier Sci Ltd, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on A serious complication of liver hydatid cysts in children: cystobiliary fistulas(Springer, 2020) Akbulut, Sami; Koc, Cemalettin; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on A Worldwide Survey of Live Liver Donor Selection Policies at 24 Centers With a Combined Experience of 19 009 Adult Living Donor Liver Transplants(Lippincott Williams & Wilkins, 2021) Akbulut, Sami; Sahin, Tevfik Tolga; Yilmaz, Sezai[Abstract Not Available]Öğe Comment on Closed Cyst Resection for Liver Hydatid Disease: a New Standard(Springer, 2020) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on current status of liver transplantation in Asia (Int J Surg 2020; 825:4-8)(Elsevier, 2021) Akbulut, Sami; Koc, Cemalettin; Sahin, Tevfik Tolga; Yilmaz, Sezai[Abstract Not Available]Öğe Comment on Evaluating Giant Hydatid Cysts: Factors Affecting Mortality and Morbidity(Int Acad Publishing Co Ltd, 2022) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on experience with LDLT in patients with hepatocellular carcinoma and portal vein tumor thrombosis postdownstaging(Elsevier Sci Ltd, 2020) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on gallbladder polyps: Correlation of size and clinicopathologic characteristics based on updated definitions(Elsevier Sci Ltd, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on hepatic artery reconstruction in living donor liver transplantation: strategy of the extension of graft or recipient artery(Taylor & Francis Ltd, 2020) Akbulut, Sami; Sahin, Tevfik Tolga; Yilmaz, Sezai[Abstract Not Available]Öğe Comment on Idiopathic Granulomatous Mastitis with Skin Rupture: A Retrospective Cohort Study of 200 Patients Who Underwent Surgical and Nonsurgical Treatment(Taylor & Francis Inc, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on idiopathic granulomatous mastitis: A systematic review of 3060 patients(Elsevier Sci Ltd, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on management and prognosis of low-grade appendiceal mucinous neoplasms: A clinicopathologic analysis of 50 cases(Elsevier Sci Ltd, 2020) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on Minimally Invasive Donor Hepatectomy for Adult Living Donor Liver Transplantation: An International, Multi-institutional Evaluation of Safety, Efficacy, and Early Outcomes''(Lippincott Williams & Wilkins, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on Neuroendocrine Tumors in Meckel's Diverticulum: Recommendation for Lymphadenectomy Regardless of Tumor Size Based on the NCDB Experience(Springer, 2020) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on Operative treatment of hepatic hydatid cysts: A single center experience(Elsevier Singapore Pte Ltd, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment On Our clinical experience and follow-up results in hydatid cyst cases: A review of 393 patients from a single center(Elsevier Sci Ltd, 2021) Akbulut, Sami; Sahin, Tevfik Tolga[Abstract Not Available]Öğe Comment on Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital(Springer, 2020) Akbulut, Sami; Sahin, Tevfik Tolga; Yilmaz, Sezai[Abstract Not Available]
