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    Apoptotic, Cytotoxic and Antimigratory Activities of Phenolic Compounds
    (Pleiades Publishing Inc, 2022) Yuce, H.; Sahin, Y.; Turkmen, N. Basak; Ozek, D. Askin; Unuvar, S.; Ciftci, O.
    The objective of this study was to evaluate the biological activities of chrysin (CRY), curcumin (CUR), and ellagic acid (EA) by comparing the anti-proliferative, anti-migration effects, and apoptotic gene expressions between the three human cancer cell lines: lung (A549), liver (HEP3B), and breast (MCF-7) compared to normal human fibroblast cell line (L929). Antiproliferative effects of certain phenolic compounds were determined by the MTS assay. Cells were treated with different concentrations of the compounds for two consecutive days. Their effect on cell migration was evaluated using the wound-healing assay. Apoptosis was evaluated by Bax, Bcl-2, Cas-3, Cas-8, Cas-9, Cas-10, CDK 2, CDK4, CDK6, CCNB1, and CCND2 gene expressions. The MTS assay showed that the compounds had antiproliferative effects on A549, HEP3B, and MCF-7 cell lines in a dose- and time-dependent manner. All three compounds also suppressed the migration of the tumor cell lines, significantly increased the levels of apoptotic gene expression, and induced apoptotic cell death. This study shows that chrysin, curcumin, and ellagic acid could be considered promising chemotherapeutic agents in the treatment of lung, liver, and breast cancers.
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    A CASE OF CONFINED PLACENTAL MOSAICISIVI WITH TRISOMY 15 ASSOCIATED WITH TURNER SYNDROME
    (Medecine Et Hygiene, 2016) Ekici, C.; Sahin, Y.; Yaykasli, K. O.; Melekoglu, R.; Sahin, N.; Yuksel, S.
    A case of confined placental mosaicism with trisomy 15 associated with Turner syndrome: We here present a rare case of a Turner syndrome with mosaic trisomy 15 identified on chorionic villous sampling (CVS). Although there are several reports in the literature indicating confined placental mosaicism (CPM), counseling parents of a fetus with trisomy 15 mosaicism at CVS remains difficult because of the phenotypic variability. To illuminate that condition an amniocentesis or cord blood study should be offered in conjunction with genetic counseling.