Yazar "Sahin, Zeynel" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    N-Alkylation and N,C-Dialkylation of Amines with Alcohols in the Presence of Ruthenium Catalysts with Chelating N-Heterocyclic Carbene Ligands
    (Amer Chemical Soc, 2015) Sahin, Zeynel; Gurbuz, Nevin; Ozdemir, Ismail; Sahin, Onur; Buyukgungor, Orhan; Achard, Mathieu; Bruneau, Christian
    A series of new benzimidazolium salts and ruthenium(II) complexes containing chelating N-heterocyclic carbenes (NHCs) functionalized with a benzylic group and an acetal group were prepared. All of the synthesized compounds were characterized by elemental analysis and NMR spectroscopy, and the molecular structures of 2c and 2d were determined by X-ray crystallography. All of the,complexes were tested in the alkylation of cyclic amine derivatives with alcohols and showed excellent activity in this reaction. Cyclic amines were alkylated with primary and heteroaromatic alcohols. The Ru-NHC Complexes also catalyzed N,C3-dialkylation of cyclic amines.
  • Küçük Resim Yok
    Öğe
    New silver, rhodium and iridium complexes with anthracene-functionalized N-heterocyclic carbene ligands: Crystal structures, cytotoxicity and fluorescence studies
    (Pergamon-Elsevier Science Ltd, 2024) Bekci, Hatice; Ozdemir, Namuk; Sahin, Zeynel; Mumcu, Akun; Dayan, Serkan; Karatas, Mert Olgun
    In the present study, we have synthesized anthracene-functionalized metal complexes to investigate their cytotoxicity and photophysical properties. In this context, firstly, an Ag - NHC (NHC = N -heterocyclic carbene) complex ( 2a ) has been synthesized by the interaction of Ag 2 O and N -(2-methylbenzyl)- N -((anthracen-9-yl) methyl)benzimidazolium chloride ( 1a ). Corresponding Rh - ( 3a ) and Ir - NHC ( 4a ) complexes have also been synthesized by the transmetalation reaction between 2a and corresponding metal compounds. Additionally, for comparison purposes, an ether-functionalized Ag - NHC complex ( 2b ) with N -(methoxyethyl)- N -((anthracene-9- yl)methyl)benzimidazole-2-ylidene ligand, and [AgL 2 ]NO 3 type complex ( 2c ) with a N -coordinated N - ((anthracen-9-yl)methyl)benzimidazole ligand have been synthesized. All complexes have been characterized by the combination of NMR and mass spectroscopic techniques, and elemental analyses. Moreover, solid state structures of 2a , 2b and 4a have been determined by the single crystal X-ray diffraction analysis. Cytotoxic potentials of all compounds have been tested against human lung adenocarcinoma alveolar basal epithelial cell line (A549) using the MTT assay, and all complexes performed strong anti-proliferative activity. Stability studies have disclosed that only 1a and 2c are able to retain their structure in the culture medium (DMEM) that biological assays were carried out. Photophysical measurements revealed that all compounds have similar emission bands because of the conjugation of anthracene group. Finally, 1a and 2c have been visualized by fluorescence confocal microscopy to investigate cellular uptake and subcellular distribution of the complexes, and the findings indicated that both compounds dispersed along the cell membranes nuclear regions.