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Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women
(Pergamon-Elsevier Science Ltd, 2004) Cekmen, MB; Balat, A; Balat, O; Aksoy, F; Yurekli, M; Erbagci, AB; Sahinoz, S
Objective: To observe the adrenomedullin (AM) and total nitrite levels in the milk of preeclamptic and normal pregnant women. Design and methods: Fifteen women with preeclampsia and 15 normal pregnant women were included in the study. Total nitrite was quantitated by Griess reaction, while AM was measured by HPLC. Results: The levels of AM and total nitrite in colostrum and 30th-day breast milk were decreased in preeclamptics. Total. nitrite levels (mumol/l) were 56.09 +/- 11.18 vs. 82.20 +/- 12.01, P < 0.05, in colostrum of preeclamptics and controls, respectively. The level of total nitrite was 37.75 +/- 12.10 vs. 53.28 +/- 10.25, P < 0.05, in 30th-day milk of same patients. AM levels (pg/ml) were 11.18 +/- 1.11 vs. 16.59 +/- 1.24, P < 0.0001, in colostrum of preeclamptics and controls, respectively. In 30th-day milk of same patients, AM levels were 8.41 +/- 1.39 vs. 12.18 +/- 1.48, P < 0.005, respectively. Conclusion: This report shows for the first time that human milk has decreased levels of AM and total nitrite in preeclampsia. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.