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    The aging kidney: A 10-year renal biopsy study of geriatric population
    (2019) Sahinturk, Yasin; Sarikaya, Metin; Dolu, Suleyman; Kok, Mehmet; Inci, Ayca; Caliskan, Ali Riza
    Aim: To report our experience with the renal biopsy/complications and histopathologic patterns of renal diseases according to their clinical presentation and to make the best disease management in the elderly patients. Material and Methods: Totally 136 patients were analyzed according to their renal biopsy histopathology, clinical diagnosis and biopsy related complications between 2006 and 2016.Results: Nephrotic syndrome (NS) and acute kidney injury (AKI) were the leading indications for renal biopsy. Totally 65 patients (47%) were diagnosed as NS and 60 patients (44%) were AKI. The most frequent histopathologic diagnosis was amyloidosis (30%). Membranous nephropathy (22%) was the second frequent histopathologic diagnosis. Amyloidosis (18.3%) was the leading cause of nephrotic syndrome and membranous nephropathy (17.6%) was the second most seen cause. Amyloidosis (11%) was the mostly seen histopathologic diagnosis of AKI. Back pain longer than 12 hours (10%) was the most common complication.Conclusion: According to our findings, renal disease of elderly differs from other age groups according to histopathologic distribution, early renal function loss and rapid progression to end stage renal disease. For an accurate early diagnosis and initiating specific treatment, renal biopsy should be performed on an individual basis without an increased risk for renal biopsy related complications.Keywords: Acute kidney injury; nephrotic syndrome; renal biopsy; elderly; renal histopathology.
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    Do hemoglobin levels affect the progression of chronic kidney disease in patients with stage 3-4 chronic kidney disease?
    (2019) Caliskan, Ali Riza; Sahinturk, Yasin; Ozdemir, Aygul; Sarikaya, Metin
    Aim: We aimed in our study to evaluate the effect of anemia on renal progression in patients with stage 3-4 CKD. Material and Methods: A total of 88 patients, 44 females, and 44 males, were followed up in a pre-dialysis outpatient clinic with a diagnosis of stage 3-4 CKD. Forty-four of these patients had hemoglobin (HGB) value above 12 g/dL, whereas 44 of them had a value between 10-12 g/dL. We accepted the first group as normal and the second group as mild anemia. We followed up the mild anemia group without Erythropoietin (EPO) treatment. Glomerular filtration rate (GFR) values were calculated with BUN, creatinine, hemoglobin, albumin and uric acid levels that had been measured in four months periods. GFR values were calculated using the MDRD formula. The follow-up duration of the two groups was twelve months. Results: Initial, fourth, eighth and twelfth months GFR values of the patients were calculated. There was no significant difference (F=1.242, p>0.05) between the GFR values of first, fourth, eighth, and twelfth months controls. GFR values measured at four different times were similar. Also, the GFR values showed no difference between the HGB groups (F=1.892, p>0.05). HGB levels did not affect GFR values measured at different times. Conclusion: It is thought that in stage 3-4 CKD, maintenance of-HGB level at 10-12 g/dL or above 12 g/dL had a similar effect on renal progression. During the follow-up of CKD, HGB level above 10 g/dL is sufficient for controlling the progression of CKD.