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Öğe Can Apelin-13 be a new actor in control of obesity?(Wiley-Blackwell, 2014) Tekin, S.; Erden, Y.; Etem, E.; Sandal, S.; Colak, C.[Abstract Not Available]Öğe Chronic intracerebroventricular apelin-13 infusion in rats increases daily food intake and body weight by reducing leptin levels(Wiley-Blackwell, 2014) Sandal, S.; Tekin, S.; Yilmaz, B.[Abstract Not Available]Öğe Comparison of exfoliated human mammary cells count with demographical and nutritional parameters of lactating mothers(Wiley-Blackwell, 2014) Agus, S.; Dinc, S. E.; Apaydin, A.; Sandal, S.; Vitrinel, A.; Yilmaz, B.[Abstract Not Available]Öğe Determination of antitumor properties of synthesized chalcone-phosphazenes containing dioxybiphenyl groups against PC-3 and LNCaP cell lines(Wiley-Blackwell, 2014) Tekin, S.; Koran, K.; Ozen, F.; Sandal, S.; Gorgulu, A. O.[Abstract Not Available]Öğe Does apelin-13 affect the development of brown fat?(Wiley-Blackwell, 2014) Yilmaz, U.; Erden, Y.; Tekin, S.; Etem, E.; Sandal, S.[Abstract Not Available]Öğe Effect of intracerebroventricular irisin injection on the uncoupling protein expression in the rat brain(Wiley-Blackwell, 2014) Tekin, S.; Erden, Y.; Etem, E.; Tektemur, A.; Kirbag, S.; Sandal, S.[Abstract Not Available]Öğe THE EFFECT OF MELATONIN ON THE EXPERIMENTALLY PRODUCED ALZHEIMER IN RATS AND RELATIONSHIP WITH FEZ1 GENE EXPRESSION(Wiley, 2017) Demir, M.; Yilmaz, U.; Sandal, S.; Colak, C.; Cigremis, Y.; Tekedereli, I.[Abstract Not Available]Öğe Effects of central salusin-beta infusion on pituitary-thyroid axis in rats(Wiley, 2019) Tekin, S.; Demir, I; Ozyalin, F.; Sandal, S.[Abstract Not Available]Öğe Effects of chronic central administration of irisin on food intake, body weight and body temperature in the rats(Wiley-Blackwell, 2014) Tekin, S.; Erden, Y.; Colak, C.; Sandal, S.[Abstract Not Available]Öğe The effects of chronic intraperitoneally infusion of irisin on liver antioxidant balance in rats(Wiley, 2017) Tekin, S.; Cakir, M.; Beytur, A.; Sandal, S.[Abstract Not Available]Öğe Effects of intracerebroventricular infusion of apelin-13 on the metabolism rate and energy expenditure(Wiley-Blackwell, 2014) Sandal, S.; Erden, Y.; Tekin, S.; Etem, E.[Abstract Not Available]Öğe Effects of N-(p-amylcinnamoyl) anthranilic acid (ACA) on various human cancer cell lines(Wiley, 2017) Tekin, S.; Cakir, M.; Beytur, A.; Sandal, S.[Abstract Not Available]Öğe Effects of saxagliptin on human prostate and breast cancer: An in vitro study(Wiley, 2017) Tekin, S.; Beytur, A.; Cakir, M.; Sandal, S.[Abstract Not Available]Öğe Estimation of the relationships between irisin concentration and food intake, body weight and body temperature using polynomial regression models in the rats(Wiley-Blackwell, 2014) Tekin, S.; Colak, C.; Erden, Y.; Sandal, S.[Abstract Not Available]Öğe Evaluation of estrogenic effects of polychlorinated biphenyls and organochlorinated pesticides using immature rat uterotrophic assay(Sage Publications Ltd, 2013) Uslu, U.; Sandal, S.; Cumbul, A.; Yildiz, S.; Aydin, M.; Yilmaz, B.In this study, we investigated the effects of polychlorinated biphenyls (PCBs) and organochlorinated pesticides on the serum levels of luteinising hormone (LH), follicle stimulating hormone (FSH) and weights and histomorphometry of uterine tissue in immature female rats using uterotrophic assay. A total of 36 rats were randomly divided into six groups (n = 6 per group) as control, oestradiol (E-2, 100 mu g/kg), PCB 180, Aroclor 1221, endosulfan and mirex at 10 mg/kg dosage. After 3 days of injections (subcutaneous), animals were decapitated and blood samples were collected. Uteri were dissected, weighed out and then fixed in 10% formaldehyde. They were processed for histomorphometry. The serum levels of LH and FSH were determined by enzyme immunoassay. Uterine weight was significantly increased by E-2 and reduced by mirex (p < 0.001 and p < 0.05, respectively). Total volume of uterus was significantly raised by E-2, Aroclor 1221 and endosulfan compared with that of the control group (p < 0.01). The ratio of epithelium was significantly increased by E-2, PCBs and pesticides (p < 0.01). The uterine cavity ratio was decreased by aroclor (p < 0.01), PCB 180 and mirex (p < 0.05). The serum levels of LH did not significantly differ among the groups but the levels of FSH were decreased by PCB 180 and endosulfan (p < 0.05 and p < 0.01, respectively). These findings suggest that PCB 180, Aroclor 1221 and endosulfan may be estrogenic in immature uterotrophic assay.Öğe Investigation on the effect of nano-TiO2 synthesized by the hydrothermal method on LNCaP cancer cells(Bulgarian Acad Science, 2017) Emre, F. B.; Okusluk, F.; Tekin, S.; Sandal, S.The nanosized TiO2 synthesis was performed through the hydrotheimal method by using titanium alkoxides. The structural, physical and chemical characteristics of the nanosized TiO2 were determined via XRD, SEM and particle size analyzer. The synthesized nano-TiO2 particles were obtained in a completely anatase form. Different concentrations of nano-TiO2's turned into sol were applied into the LNCaP cells in the cell culture media, and their antitumour/proliferation activities were tried to be determined photocatalytically with and without the UV-ray. For this, the numbers of living and dead cells were detected by means of MTT method, and thus, the anticancer characteristic was determined.Öğe Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?(Comenius Univ, 2019) Demir, M.; Yilmaz, U.; Colak, C.; Cigremis, Y.; Ozyalin, F.; Tekedereli, I; Sandal, S.Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart. MLT injections were implemented for 14 days (ip; 10mg/kg/day). The Morris Water Maze (MWM) test was performed and rats were sacrificed to assess FEZ1 gene expression and protein levels from the hippocampus tissues and serum levels of noradrenaline (NA), dopamine and serotonin were determined from the blood samples. It was determined that the FEZ1/beta-actin protein ratio in the STZ group was significantly higher than that of the Vehicle group (p < 0.05) and in the MLT-administered group, the protein levels were decreased to the levels observed in the Vehicle group. Serum NA levels of STZ and STZ+MLT groups were found to be lower than those in the Vehicle group, while no difference was found regarding dopamine and serotonin levels. These findings show that reversal of increased FEZ1 levels in AD-induced rats with melatonin administration is the evidence of the effect of melatonin through FEZ1 in AD (Tab. 2, Fig. 5, Ref. 67).Öğe New synthesized phosphazenes containing chalcone on human prostate cancer cell lines: An in vitro study(Wiley-Blackwell, 2014) Tekin, S.; Koran, K.; Ozen, F.; Sandal, S.; Cil, E.; Gorgulu, A. O.[Abstract Not Available]Öğe The relationship between Saxagliptin and renal ischemia/reperfusion: A morphological approach(Wiley, 2017) Tekin, S.; Beytur, A.; Taslidere, A.; Cakir, M.; Sandal, S.[Abstract Not Available]Öğe Synthesis of New 1,1,3,3-Tetra(4?-oxy-3-substituted-chalcone)-5,5-diphenylcyclotriphosphazene Derivatives and Investigation of Their Anti Cancer Activities(Wiley, 2017) Tekin, S.; Tekin, I.; Koran, K.; Gorgulu, A. O.; Sandal, S.[Abstract Not Available]
