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Öğe Eight different viral agents in childhood acute gastroenteritis(Turkish J Pediatrics, 2015) Bozkurt, Derya; Selimoglu, Mukadder Ayse; Otlu, Baris; Sandikkaya, AyseViral gastroenteritis is the most frequent cause of acute gastroenteritis (AGE) of childhood. The aim of this study was to determine the prevalence of viral agents including astrovirus, rotavirus, adenovirus, enterovirus, norovirus, parechovirus, Aichivirus and sapovirus in children with AGE in a pediatric Turkish population. Fecal specimens of 240 children with AGE were investigated by polymerase chain reaction, and viral agents were identified in 131 (54.6%) samples. The distribution of viral agents was as follows: 56 (42.8%) norovirus, 44 (33.6%) rotavirus, 29 (22.1%) enterovirus, 21 (16.0%) adenovirus, 21 (16.0%) parechovirus, 5 (3.8%) sapovirus and 1 (0.8%) Aichivirus. Single and multiple viral agents were detected in 38.8% and 15.8% of patients, respectively. The duration of hospitalization was longer in children with multiple viral agents than in those infected with a single viral agent (p<0.001). While the highest rate of rotavirus infection was detected in winter, the highest rate of norovirus was found in the summer. In conclusion, norovirus and rotavirus are the most frequent causes of childhood AGE in our country.Öğe Evaluation by N-terminal Prohormone of Brain Natriuretic Peptide Concentrations and Ross Scoring of the Efficacy of Digoxin in the Treatment of Heart Failure Secondary to Congenital Heart Disease With Left-to-Right Shunts(Springer, 2013) Elkiran, Ozlem; Sandikkaya, Ayse; Kocak, Gulendam; Karakurt, Cemsit; Taskapan, Cagatay; Yologlu, SaimThis study aimed to evaluate the effectiveness of digoxin in children with heart failure secondary to left-to-right shunt lesions and normal left ventricular systolic function. The study registered 37 such patients (ages 10 days to 24 months, groups 1 and 2) and used 20 healthy children as a control group (group 3). Left ventricular systolic function, as assessed by conventional echocardiography, was normal in all the subjects. Congestive heart failure was diagnosed by clinical evaluation and modified Ross scoring. Plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations and complete blood counts were assessed in all the children. Group 1 was treated with digoxin, enalapril, and furosemide and group 2 with enalapril and furosemide. Approximately 1 month after starting treatment, the patients were reevaluated by physical and echocardiographic examinations, modified Ross scoring, plasma NT-proBNP concentrations, and complete blood counts. The pre- and posttreatment Ross scores of group 1 (p = 0.377) and group 2 (p = 0.616) did not differ significantly. The NT-proBNP values in both groups decreased after treatment (p = 0.0001). The pre- and posttreatment NT-proBNP values did not differ significantly in group 1 (p = 0.094)) and group 2 (p = 0.372). The pretreatment NT-proBNP values in groups 1 and 2 (p = 0.0001) were significantly higher than in the control group (p = 0.003). A smaller difference was observed between posttreatment NT-proBNP values in group 1 and the control group (p = 0.045). We found no significant difference between the posttreatment NT-proBNP values of group 2 and those of the control group (p = 0.271). The study showed that both treatments currently used to treat heart failure secondary to congenital heart disease with left-to-right shunts and preserved left ventricular systolic function are effective and do not differ significantly. Thus, digoxin does not provide any extra benefit in the treatment of such patients.Öğe A Newborn with Massive Congenital Astroblastoma(Informa Healthcare, 2011) Turkmen, Emine; Raisanen, Jack; Dogan, Metin; Sandikkaya, Ayse; Dogan, Derya Gumus; Sahin, Nurhan; Karadag, Ahmet[Abstract Not Available]Öğe Publication Pattern of Turkish Medical Theses: Analysis of 22.625 Medical Theses Completed in Years 1980-2005(Ortadogu Ad Pres & Publ Co, 2011) Ozgen, Unsal; Egri, Mucahit; Aktas, Mumtaz; Sandikkaya, Ayse; Ozturk, O. Faruk; Can, Sermet; Ozcan, CemalObjective: The objective of this study was to determine the conversion rates of Turkish residency theses to scientific articles. Material and Methods: 22.625 residency theses written at 28 university hospitals, nine state hospitals and two military hospitals' residency programmes and recorded at the web of National Thesis Center were searched through Web of Science in order to evaluate their publication pattern in SCI-expanded journals in 1980-2005. Results: The number of published thesis at SCI expanded journals was found to be 1397 (6.2%) with the median number of citations received per paper ranging from 0.3 to 5.0. Publication percentage was highest for theses written at military hospitals and lowest for those written at state hospitals. Conclusion: Percentage of published thesis in Turkey is lower when compared to the remaining European Countries. Therefore, we need alternative practices to use our manpower, time and financial resources more effectively. The first alternative is to put an end to the obligation to write thesis in order to complete residency training in some types of hospitals or to convert this obligation to an option. Another alternative is to establish a National Thesis Advisory Center and make it essential to get approval from this center in order to conduct a thesis project.
