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Öğe Burun tıkanıklığının nadir bir sebebi: inferior konka bülloza(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Sapmaz, Emrah; Sapmaz, Hilal Irmak; Toplu, Yüksel; Öçalan, Ramazan; Karaer, Işıl Çakmakİnferior konka bülloza oldukça nadir görülen bir anatomik varyasyondur. İnferior konka bülloza, inferior konkanın kemik lamelinin içerisinde hava keseciğinin olmasıdır ve bazen bu hava kesesi maksiller sinüslede alakalı olabilir. Genellikle asemptomatiktir ve görüntüleme yöntemleriyle tesadüfen tespit edildir. Bazen burun tıkanıklığı, baş ağrısı ve geniz akıntısı gibi semptomlarla neden olabilir. Tedavisinde çeşitli teknikler tarif edilmiştir. Biz bu makalede 23 yaşında burun tıkanıklığı, baş ağrısı ve geniz akıntısı nedeniyle kliniğimize baş vuran ve üst orta ve alt konklarda konka bülloza tespit ettiğimiz,,inferior konka büllozanın tedavisinde lateralizasyon ve radyofrekansla ablasyon yaptığımız aynı zamanda orta konka büllozaya parsiyel rezeksiyon uyguladığımız bir bayan vakayı sunduk.Öğe Clinical results and health-related quality of life in otoplasty patients using cartilage resection and suturing methods(Springer, 2014) Toplu, Yuksel; Sapmaz, Emrah; Firat, Cemal; Toplu, Sibel AltunisikIn this study, we evaluated clinical results and health-related quality of life in our otoplasty patients in whom we used cartilage resection method (CRM) and suturing method (SM). A total of 132 ears of 77 patients (36 males, 41 females; mean age 14.6 +/- 6.4) between January 2006 and February 2013 were included in this study. Patients were divided into two groups according to the type of surgery performed: Group 1 was the cartilage resection group (CRG) and Group 2 was the suturing group (SG). CRM was performed on 64 ears of 37 patients (unilateral in 10 cases and bilateral in 27 cases), and SM was performed on 68 ears of 40 patients (unilateral in 12 cases and bilateral in 28 cases). The parameters of the groups, including operation time, measurements of the auriculocephalic distances, complication rates, postoperative satisfaction rates, and health-related quality of life were compared. Mean operation time was 53.7 +/- 7.8 min in the CRG and 44.9 +/- 4.2 min in the SG (P a parts per thousand currency sign 0.05). Mean postoperative auriculocephalic measurements were similar in both groups. The complications were more frequent in the CRG (10/37 patients, 27.02 %) than in the SG (3/40 patients, 7.54 %) with statistically significant difference (P < 0.05). Three months after the surgery, visual analog scale increased from 25 (preoperatively) to 70 in the CRG and from 30 to 90 in the SG, with a statistically significant difference (P < 0.05). Patients' health-related quality of life showed a statistically significant increase after the operation in both groups (P < 0.05). CRM and SM are effective treatment methods with high success rates for patients with prominent ears. In the selected cases, SM seems to represent a better option for otoplasty than CRM because clinical results, cosmetic outcomes, patient satisfaction, and health-related quality of life scores were better than CRM.Öğe Disfajinin Nadir Bir Sebebi; Diffüz İdiopatik İskelet Hiperostozisi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Sapmaz, Emrah; Keleş, ErolDiffüz idiopatik iskelet hiperosteozisi etiyolojisi kesin olarak bilinmeyen travmatik, post enfeksiyöz ve dejeneratif olaylardan bağımsız olarak paravertebral ligamanların enkondral ossifikasyonu ile karakterize bir hastalıktır. Vücutta bir çok kemik tutulumu olabilir fakat en sık tutulum vertebralardadır. Tanısı primer olarak radyolojiktir. Servikal vertebra tutulumu olan hastalarda yutma güçlüğü boyun hareketlerinde kısıtlılık ses kısıklığı ve nefes almada zorluk şikayetleri olabilir. Biz bu makalede 63 yaşında disfaji nedeniyle değerlendirdiğimiz ve diffüz idiopatik iskelet hiperosteozis tanısı konulan bir vakayı sunduk.Öğe Efeito da genisteina na ototoxicidade induzida pela cisplatina e estresse oxidativo(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2022) Tan, Mehmet; Toplu, Yuksel; Varan, Emrah; Sapmaz, Emrah; Ozhan, Onural; Parlakpinar, Hakan; Polat, AlaadinObjetivo: A cisplatina e um agente antineoplasico usado em adultos e criancas para o tra-tamento de diversas lesoes malignas. Pode causar ototoxicidade irreversivel. A genisteina e um fitoestrogeno que funciona como antioxidante e inibidor do ciclo celular ao inibir as enzi-mas DNA topoisomerase e tirosina-quinase. O efeito protetor da genisteina na prevencao da ototoxicidade induzida pela cisplatina e os niveis de estresse oxidativo foram investigados. Metodo: Trinta e dois ratos Sprague Dawley foram usados em 4 grupos (controle, cisplatina, cis-platina + genisteina, genisteina). As medidas das emissoes otoacusticas por produto de distorcao foram tomadas nos dias 1, 2 e 5 do protocolo do teste. Foram medidos os niveis sericos de malondialdeido, superoxido dismutase, catalase, glutationa peroxidase, estado antioxidante total, estado oxidante total e indice de estresse oxidativo. Resultados: A audicao do grupo cisplatina + genisteina foi melhor do que a do grupo cisplatina. Enquanto os parametros malondialdeido, estado oxidante total e indice de estresse oxidativo diminuiram significantemente no grupo cisplatina + genisteina em comparacao com o grupo cisplatina, o superoxido dismutase mostrou aumento significantemente (p < 0,05). Conclusao: A genisteina apresentou efeitos positivos contra a ototoxicidade com seu efeito antioxidante. Nivel de evidencia: Nivel 3. (c) 2021 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Publicado por Elsevier Editora Ltda. Este e um artigo Open Access sob uma licenca CC BY (http:// creativecommons.org/licenses/by/4.0/).Öğe The effect of dexpanthenol on ototoxicity Induced by cisplatin(Clin Exp Otorhinolaryngol., 2016) Toplu, Yüksel; Sapmaz, Emrah; Parlakpınar, Hakan; Kelleş, Mehmet; Kalcıoğlu, Mahmut Tayyar; Tanbek, Kevser; Kızılay, AhmetObjectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.Öğe The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin(Korean Soc Otorhinolaryngol, 2016) Toplu, Yuksel; Sapmaz, Emrah; Parlakpinar, Hakan; Kelles, Mehmet; Kalcioglu, M. Tayyar; Tanbek, Kevser; Kizilay, AhmetObjectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P <0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group's measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.Öğe Measurement of Frontal Sinus Volume by Using Computed Tomography: A Stereological Study(Derman Medical Publ, 2015) Sapmaz, Hilal Irmak; Tugtag, Berin; Sapmaz, Emrah; Kose, Evren; Ozbag, Davut; Uysal, MuratAim: Paranasal sinuses are the anatomic regions that are frequently affected by allergic diseases and infections, thus it is substantial to comprehend the morphological structure of these regions for surgery. The aim of our study is to obtain stereological evaluation of frontal sinus volumes of female and male individuals by using computerized tomography (CT). Material and Method: This study assessed the CT images of 140 cases (70 male, 70 female) were at the age of 20 to 60 years and didn't have a disease of frontal sinus. Frontal sinus volumes were calculated stereologically on coronal plane sections by using planimetric method via Cavalieri principle. Results: When the data of male and female individuals were compared statistically; it was observed that frontal sinus volumes of men were larger. Average frontal sinus volume of women was 4,04 +/- 1,84 cm(3) and it was 7,02 +/- 2,78 cm(3) for men. Discussion: Significant advancement was obtained for paranasal sinus imaging by the use of CT, magnetic resonance imaging and three dimensional imaging techniques. In our study, frontal sinus volumes of adult individuals were measured by using planimetry method and it was detected significantly larger in men. Since frontal sinus is one of the paranasal sinuses that reveal asymmetrical development, it is clinically important to seek out its volume. In conclusion; we think that determination of the frontal sinus volume will make a major contribution to physicians for inflammatory sinus diseases, frontal sinus traumas and endoscopic sinus surgery.Öğe Nasolacrimal duct obstruction with obstructive nasal deformity; is synchronous nasal surgery necessary?(2021) Toplu, Yuksel; Bayindir, Tuba; Balbaba, Mehmet; Kalcioglu, Mahmut Tayyar; Sapmaz, Emrah; Karatas, ErkanThe aim of this study was to evaluate the necessity of the simultaneous additional nasal surgery to increase success rate of the endoscopic dacryocystorhinostomy operation, in the patients with nasolacrimal duct obstruction and obstructive nasal deformity. One hundred and thirty patients with nasolacrimal duct obstruction and obstructive nasal deformity (59 were female and 71 male, age ranged between 31 and 82 years, mean=60.3 years) were included in this study. Patients with nasolacrimal duct obstruction were divided into two main groups (group A and B) and six subgroups (A1, A2, A3 and B1, B2, B3) according to the presence of obstructive nasal deformity and applied operation techniques. The success and complications rates of this groups were evaluated. The success rates of endoscopic dacryocystorhinostomy in the additional nasal surgery performed group (Group A) were not statistically significant higher than the group without additional nasal surgery (Group B). Complications rate of group A (26.08%) were statistically significant higher than group B (9.8%). In patients with complications, the average success rate of endoscopic dacryocystorhinostomy surgery (70.8%) was statistically significant lower than in patients with no complications (88.6%), respectively. Additional nasal surgery has no statistically significant effect on the success of the endoscopic dacryocystorhinostomy surgery. Developing complications was statistically affect the success rate of endoscopic dacryocystorhinostomy surgery. Due to these reasons, contrary to the general idea, we believe that, to increase the success rate of the endoscopic dacryocystorhinostomy surgery, additional nasal surgery is unnecessary in patients with nasolacrimal duct obstruction and obstructive nasal deformity.Öğe A new classification for septal perforation and effects of treatment methods on quality of life(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2019) Sapmaz, Emrah; Toplu, Yuksel; Somuk, Battal TahsinIntroduction: Septal perforation is a condition characterized by toss of cartilage and/or bony structures along with the mucoperichondrium and mucoperiosteum lining them. The etiology includes a history of nasal surgery or trauma, nose picking, bilateral septal cauterization, overuse of nasal sprays, cocaine abuse, vasculitis, and malignancies. Objective: Comparison of quality of life in patients with septal perforation after conservative or surgical treatment, and a new approach for the determination of the diameter of the perforation from a different point of view. Methods: The diameter of septal perforation, total vertical diameter of septum, and horizontal diameter of the perforation were measured in a total of 34 patients. Nineteen of the patients underwent surgical septal perforation repair, and 15 of them received septal button application. The patients were asked to complete the Glasgow Benefit Inventory quality of life questionnaire. Results: The septal perforation successfully healed in 18 of 19 patients who underwent surgical treatment. The quality of life scores were statistically significantly higher in the surgical treatment group when compared to the button group (p <0.05). Conclusion: The septal perforation classification we propose would be beneficial for providing realistic dimensions, treatment methods, and surgical techniques. (C) 2018 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Öğe Otoplasty: results of suturing and scoring techniques(Springer, 2014) Toplu, Yuksel; Sapmaz, Emrah; Toplu, Sibel Altunisik; Deliktas, HacimIn this study, we evaluated our otoplasty surgery results in patients with prominent ears. A total of 76 ears in 42 patients (20 male, 22 female; mean age 14; range 6-34 years) who underwent otoplasty surgery under general anesthesia between April 2005 and February 2012 were evaluated retrospectively. Of the 76 surgical cases, while 65 were operated on for the first time (primary), 6 had had previous unsuccessful surgical interventions at other institutes (secondary) and 5 were our own revision surgery cases. Of the primary cases; 11 had unilateral and 27 had bilateral surgery. Postoperative follow-ups were performed at week one, months one, three and six and at 1 year. While 60 of the 65 primary surgeries and all 6 of the secondary surgeries had successful results, 5 cases required revision surgery. The revision otoplasty surgeries were found to be successful in all patients on follow-up visits. Otoplasty surgery is an effective treatment method with high success rates for patients with prominent ears.Öğe The protective role of molsidomine on the cisplatin Induced ototoxicity(Indian Journal of Otolaryngology and Head & Neck Surgery, 2014) Toplu, Yüksel; Parlakpınar, Hakan; Sapmaz, Emrah; Karataş, Erkan; Polat, Alaattin; Kızılay, AhmetThis experimental study was designed to investigate the protective effects of molsidomine (MOL) on against cisplatin-induced ototoxicity (CIO). To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status [including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI)] were evaluated. Thirty-two female wistar albino rats were divided into four groups including; control (Group K), cisplatin (Group C), cisplatin plus MOL group (Group CM), and MOL group (Group M). DPOAEs measurements between 0.9961 and 8.0003 Hz as DP-gram and input/output (I/O) functions were performed in the same (left) ear of all rats on days 0, 1st, 5th and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. In the C group, statistically significant DPOAE amplitude reductions were detected at 2.5195, 3.1758, 3.9961, 5.0391, 6.3516 and 8.0039 Hz frequencies (p\0.05) between 0th and 1st, 0th and 5th and 0th and 12th days’ measurements (p\0.05). Serum level of MDA, TAC and OSI levels were significantly higher in the C group versus K group (p\0.05). In the CM group, there were no significant differences at all frequencies between 0th and other days’ measurements (p[0.05) and the serum levels of all biochemical parameters were shifted toward normal values, similar to the K group (p\0.05). No significant differences were detected in the either M or K group’s measurements. According to these results, cisplatin-related ototoxicity has been significantly prevented by MOL.Öğe The Protective Role of Molsidomine on the Cisplatin-Induced Ototoxicity(Springer India, 2014) Toplu, Yuksel; Parlakpinar, Hakan; Sapmaz, Emrah; Karatas, Erkan; Polat, Alaattin; Kizilay, AhmetThis experimental study was designed to investigate the protective effects of molsidomine (MOL) on against cisplatin-induced ototoxicity (CIO). To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status [including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI)] were evaluated. Thirty-two female wistar albino rats were divided into four groups including; control (Group K), cisplatin (Group C), cisplatin plus MOL group (Group CM), and MOL group (Group M). DPOAEs measurements between 0.9961 and 8.0003 Hz as DP-gram and input/output (I/O) functions were performed in the same (left) ear of all rats on days 0, 1st, 5th and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. In the C group, statistically significant DPOAE amplitude reductions were detected at 2.5195, 3.1758, 3.9961, 5.0391, 6.3516 and 8.0039 Hz frequencies (p < 0.05) between 0th and 1st, 0th and 5th and 0th and 12th days' measurements (p < 0.05). Serum level of MDA, TAC and OSI levels were significantly higher in the C group versus K group (p < 0.05). In the CM group, there were no significant differences at all frequencies between 0th and other days' measurements (p[0.05) and the serum levels of all biochemical parameters were shifted toward normal values, similar to the K group (p < 0.05). No significant differences were detected in the either M or K group's measurements. According to these results, cis-platin-related ototoxicity has been significantly prevented by MOL.Öğe A Rare Cause of Nasal Obstruction: Concha Bullosa of the Inferior Turbinate(2014) Sapmaz, Emrah; Sapmaz, Hilal Irmak; Toplu, Yüksel; Öçalan, Ramazan; Karaer, Işıl Çakmakİnferior konka bülloza oldukça nadir görülen bir anatomik varyasyondur. İnferior konka bülloza, inferior konkanın kemik lamelinin içerisinde hava keseciğinin olmasıdır ve bazen bu hava kesesi maksiller sinüslede alakalı olabilir. Genellikle asemptomatiktir ve görüntüleme yöntemleriyle tesadüfen tespit edildir. Bazen burun tıkanıklığı, baş ağrısı ve geniz akıntısı gibi semptomlarla neden olabilir. Tedavisinde çeşitli teknikler tarif edilmiştir. Biz bu makalede 23 yaşında burun tıkanıklığı, baş ağrısı ve geniz akıntısı nedeniyle kliniğimize baş vuran ve üst orta ve alt konklarda konka bülloza tespit ettiğimiz,,inferior konka büllozanın tedavisinde lateralizasyon ve radyofrekansla ablasyon yaptığımız aynı zamanda orta konka büllozaya parsiyel rezeksiyon uyguladığımız bir bayan vakayı sundukÖğe A Rare Cause of Nasal Obstruction: Concha Bullosa of the Inferior Turbinate(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Sapmaz, Emrah; Sapmaz, Hilal Irmak; Toplu, Yüksel; Öçalan, Ramazan; Karaer, Işıl ÇakmakConcha bullosa of the inferior turbinate is an extremely rare anatomic malformation. Inferior concha bullosa is the structure with air sacs on the inferior turbinate body and may be associated with maxillary sinus. Inferior concha bullosa is generally asymptomatic and diagnosed incidentally by computed tomography. Its main clinical symptoms are nasal obstruction, headache, and postnasal drip. Several techniques have been suggested as treatment options. With this study, we intend to report the case of a 23 year old woman who has nasal obstruction, headache, and postnasal drip was diagnosed with inferior, middle and superior concha bullosa and we have performed laterization through radiofrequency ablation on inferior turbinate and partial resection on the middle turbinate.Öğe An Unusual Cause of Conductive Hearing Loss: Bilateral Complete Meatal Obstruction Following Otoplasty(Lippincott Williams & Wilkins, 2014) Toplu, Yuksel; Toplu, Sibel Altunisik; Sapmaz, Emrah; Deliktas, HacimThere are many causes of conductive hearing loss. Otoplasty is a commonly performed cosmetic surgery to correction for prominent ear. We discussed an unusual cause of conductive hearing loss, bilateral complete meatal obstruction following otoplasty, in this article. This complication was probably due to unsuitable placement of the Furnas sutures. In the literature, as a cause of conductive hearing loss, unilateral complete meatal obstruction has been described rarely, but bilateral complete obstruction has not been defined. Hearing loss recovered completely after revision surgery. Correct diagnosis, accurate preoperative or perioperative examination, choice of the proper technique and surgeon experience are essential for avoiding inadequate results or complications of otoplasty. The surgeon should be aware of the cartilage elasticity and suture techniques to avoid this complication.
