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Öğe Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats(Taylor & Francis Ltd, 2012) Beytur, Ali; Kose, Evren; Sarihan, Mehmet Ediz; Sapmaz, Hilal Irmak; Dogan, Zumrut; Cetin, Asli; Vardi, NigarObjective: In this study, the therapeutic and protective effects of montelukast against cisplatin (CP)-induced acute renal damage were investigated. Materials and Methods: Thirty-five female rats were divided into five groups as follows: (1) control, (2) montelukast (10 mg/kg daily for 10 days per-oral (p.o.), (3) CP (single dose 7 mg/kg intraperitoneally (i.p.)), (4) CP + montelukast (10 mg/kg daily for 10 days p.o., after 3 days of the injection of CP), (5) montelukast (10 mg/kg daily for 10 days p.o.) + CP (single dose 7 mg/kg i.p., after the last dose of montelukast). At the end of the experiment, malondialdehyde (MDA), a lipid peroxidation product, myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined in the renal tissue. Also, blood urea nitrogen (BUN) and creatinine (Cr) levels were assayed from the trunk blood samples. Results: CP treatment caused a significant elevation of MDA, MPO, BUN, and Cr levels when compared with the control group. Also, GSH levels were found to be reduced due to the CP treatment. Montelukast administration after CP injection ameliorated all of these parameters. Our histopathological findings (marked swelling of epithelial cells, tubular dilatation, tubular desquamation, and loss of brush border in the kidney) were consistent with the biochemical results. Conclusion: Montelukast treatment after CP injection exerted therapeutic effects against CP-induced acute kidney damage.Öğe Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study(Hindawi Ltd, 2012) Kose, Evren; Sapmaz, Hilal Irmak; Sarihan, Ediz; Vardi, Nigar; Turkoz, Yusuf; Ekinci, NihatThe effects of montelukast against methotrexate-induced liver damage were investigated. 35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx). At the end of the experiment, the liver tissues of rats were removed. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues. In addition, the liver tissues were examined histologically. MDA and MPO levels of Mtx group were significantly increased when compared to control group. In Mtx + ML group, these parameters were decreased as compared to Mtx group. Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes. The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls. ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present. It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.Öğe Burun tıkanıklığının nadir bir sebebi: inferior konka bülloza(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Sapmaz, Emrah; Sapmaz, Hilal Irmak; Toplu, Yüksel; Öçalan, Ramazan; Karaer, Işıl Çakmakİnferior konka bülloza oldukça nadir görülen bir anatomik varyasyondur. İnferior konka bülloza, inferior konkanın kemik lamelinin içerisinde hava keseciğinin olmasıdır ve bazen bu hava kesesi maksiller sinüslede alakalı olabilir. Genellikle asemptomatiktir ve görüntüleme yöntemleriyle tesadüfen tespit edildir. Bazen burun tıkanıklığı, baş ağrısı ve geniz akıntısı gibi semptomlarla neden olabilir. Tedavisinde çeşitli teknikler tarif edilmiştir. Biz bu makalede 23 yaşında burun tıkanıklığı, baş ağrısı ve geniz akıntısı nedeniyle kliniğimize baş vuran ve üst orta ve alt konklarda konka bülloza tespit ettiğimiz,,inferior konka büllozanın tedavisinde lateralizasyon ve radyofrekansla ablasyon yaptığımız aynı zamanda orta konka büllozaya parsiyel rezeksiyon uyguladığımız bir bayan vakayı sunduk.Öğe Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: An experimental study(Sage Publications Inc, 2016) Sapmaz, Hilal Irmak; Sarsilmaz, Mustafa; Godekmerdan, Ahmet; Ogeturk, Murat; Tas, Ufuk; Kose, EvrenAim: This study was carried out to determine the effects of formaldehyde (FA) inhalation on the humoral immunity of rats and the protective effect of Nigella sativa (NS) oil. Materials and Methods: The rats (n = 33) were divided into five groups, with five animals in the control group (FA-free air) and seven in the other four groups. Group FA I was exposed to FA (5 ppm), group FA NS I was treated with NS and exposed to FA (5 ppm), group FA2 was exposed to FA (10 ppm), and group FA + NS2 was treated with NS and exposed to FA (10 ppm). At the end of a 4-week study period, blood samples were collected. Enzyme-linked immunosorbent assay was used to determine the levels of serum total immunoglobulin A (IgA), total immunoglobulin M (IgM), total immunoglobulin G (IgG), and complement 3 (C3). Results: FA inhalation significantly increased serum IgA, IgM, and C3 levels and decreased serum IgG levels compared with the control group. NS administration decreased serum IgA, IgM, and C3 levels, which were induced by FA inhalation. Conclusion: FA inhalation significantly increased acute antibody responses and C3 levels in a dose-dependent manner compared with the control group. FA inhalation decreased the secondary immune response compared with the control group. Levels of acute antibody responses and complement following exposure to FA inhalation returned to normal following treatment with NS (immunoregulatory effect). However, NS did not affect the secondary immune response.Öğe HSP70 immune reactivity and TUNEL positivity in the liver of toluene-inhaled and melatonin-treated rats(Sage Publications Inc, 2013) Tas, Ufuk; Ogeturk, Murat; Kuloglu, Tuncay; Sapmaz, Hilal Irmak; Kocaman, Nevin; Zararsiz, Ismail; Sarsilmaz, MustafaToluene is a clear, colorless and volatile hydrocarbon that is metabolized in liver, produced free oxygen radicals and can mediate cellular damage. Melatonin which is a pineal gland hormone is a very potent antioxidant. It can make the cellular membrane more durable against oxidative attacks and protect nuclear DNA from oxidative damage. This study aimed to investigate heat shock protein (HSP)70 immune reactivity and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) positivity (apoptotic activity) in the liver of toluene-inhaled and melatonin-treated rats. A total of 21 adult male Wistar albino rats were divided at random into 3 equal groups. Animals in group I were designated as control. The rats in group II were exposed to toluene (3000ppm/1h/day) for 30 days, while the rats in group III were treated with melatonin (10mg/kg/day, intraperitoneally) plus toluene inhalation. At the end of the 30-day experimental period, all rats were killed by decapitation. Then the liver tissues of rats were removed and tissue specimens were embedded in paraffin blocks. The specimens were stained with periodic acid-schiff (PAS) following routine histological procedures. Sections obtained from paraffin blocks were used for immune detection of TUNEL and HSP70. In light microscopic observations of tissues from toluene-inhaled rats, massive hepatocyte degeneration, ballooning degeneration and decreased PAS positivity were observed. Increased TUNEL positivity and HSP70 immune reactivity were determined in toluene-inhaled group and melatonin treatment decreased all these adverse effects.Öğe Measurement of Frontal Sinus Volume by Using Computed Tomography: A Stereological Study(Derman Medical Publ, 2015) Sapmaz, Hilal Irmak; Tugtag, Berin; Sapmaz, Emrah; Kose, Evren; Ozbag, Davut; Uysal, MuratAim: Paranasal sinuses are the anatomic regions that are frequently affected by allergic diseases and infections, thus it is substantial to comprehend the morphological structure of these regions for surgery. The aim of our study is to obtain stereological evaluation of frontal sinus volumes of female and male individuals by using computerized tomography (CT). Material and Method: This study assessed the CT images of 140 cases (70 male, 70 female) were at the age of 20 to 60 years and didn't have a disease of frontal sinus. Frontal sinus volumes were calculated stereologically on coronal plane sections by using planimetric method via Cavalieri principle. Results: When the data of male and female individuals were compared statistically; it was observed that frontal sinus volumes of men were larger. Average frontal sinus volume of women was 4,04 +/- 1,84 cm(3) and it was 7,02 +/- 2,78 cm(3) for men. Discussion: Significant advancement was obtained for paranasal sinus imaging by the use of CT, magnetic resonance imaging and three dimensional imaging techniques. In our study, frontal sinus volumes of adult individuals were measured by using planimetry method and it was detected significantly larger in men. Since frontal sinus is one of the paranasal sinuses that reveal asymmetrical development, it is clinically important to seek out its volume. In conclusion; we think that determination of the frontal sinus volume will make a major contribution to physicians for inflammatory sinus diseases, frontal sinus traumas and endoscopic sinus surgery.Öğe Protective efficacy of Nigella sativa oil against the harmful effects of formaldehyde on rat testicular tissue(Wolters Kluwer Medknow Publications, 2018) Sapmaz, Hilal Irmak; Yildiz, Azibe; Polat, Alaadin; Vardi, Nigar; Kose, Evren; Tanbek, Keyser; Cuglan, SongulObjective: To explore the effects of Nigella sativa oil (NSO) on the histopathological and biochemical changes that inhaled formaldehyde (FA) induces on the testicular tissue of rats. Methods: Thirty three adult male rats were separated into five groups as follows: C, the control group; 4FA group which received FA for 4 weeks; 13FA group which was given FA for 13 weeks; 4FA+NSO group which was administered FA plus NSO for 4 weeks; 13FA+NSO group which was treated with FA plus NSO for 13 weeks. FA was administered through inhalation for 8 h 5 days a week at a dose of 5 ppm in a special glass cage, and NSO was administered orally 1 mL/kg once daily. Rats were decapitated at the end of the experiment and testicular tissue specimens were harvested for histopathologic and biochemical assessment. Results: Compared to the C group, reduction was observed in the number of intact tubules and in the mean germinative epithelium thickness of the FA groups. Significant increase was observed in the number of intact tubules with the long-term (13 weeks) administration of NSO together with FA. Reduced glutathione peroxidase activity was found and oxidative stress index values were measured higher in the 4FA and 13FA groups versus the C group (P<0.05). Moreover, total antioxidant status levels decreased only in the 4FA group (P<0.05) while only the 13FA group significantly increased malondialdehyde levels and reduced catalase activities in comparison with the C group. In the 13FA+NSO group, malondialdehyde levels decreased however glutathione peroxidase and catalase activities increased compared to the 13FA group. Differences measured in total antioxidant status levels were found to be statistically significant only between the 4FA and the 4FA+NSO groups. Conclusions: NSO as an antioxidant should be used for a longer term to achieve protective efficacy both histoparhologically and biochemically in the testicular tissue.Öğe A Rare Cause of Nasal Obstruction: Concha Bullosa of the Inferior Turbinate(2014) Sapmaz, Emrah; Sapmaz, Hilal Irmak; Toplu, Yüksel; Öçalan, Ramazan; Karaer, Işıl Çakmakİnferior konka bülloza oldukça nadir görülen bir anatomik varyasyondur. İnferior konka bülloza, inferior konkanın kemik lamelinin içerisinde hava keseciğinin olmasıdır ve bazen bu hava kesesi maksiller sinüslede alakalı olabilir. Genellikle asemptomatiktir ve görüntüleme yöntemleriyle tesadüfen tespit edildir. Bazen burun tıkanıklığı, baş ağrısı ve geniz akıntısı gibi semptomlarla neden olabilir. Tedavisinde çeşitli teknikler tarif edilmiştir. Biz bu makalede 23 yaşında burun tıkanıklığı, baş ağrısı ve geniz akıntısı nedeniyle kliniğimize baş vuran ve üst orta ve alt konklarda konka bülloza tespit ettiğimiz,,inferior konka büllozanın tedavisinde lateralizasyon ve radyofrekansla ablasyon yaptığımız aynı zamanda orta konka büllozaya parsiyel rezeksiyon uyguladığımız bir bayan vakayı sundukÖğe A Rare Cause of Nasal Obstruction: Concha Bullosa of the Inferior Turbinate(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Sapmaz, Emrah; Sapmaz, Hilal Irmak; Toplu, Yüksel; Öçalan, Ramazan; Karaer, Işıl ÇakmakConcha bullosa of the inferior turbinate is an extremely rare anatomic malformation. Inferior concha bullosa is the structure with air sacs on the inferior turbinate body and may be associated with maxillary sinus. Inferior concha bullosa is generally asymptomatic and diagnosed incidentally by computed tomography. Its main clinical symptoms are nasal obstruction, headache, and postnasal drip. Several techniques have been suggested as treatment options. With this study, we intend to report the case of a 23 year old woman who has nasal obstruction, headache, and postnasal drip was diagnosed with inferior, middle and superior concha bullosa and we have performed laterization through radiofrequency ablation on inferior turbinate and partial resection on the middle turbinate.Öğe The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development(Medicine Science | International Medical Journal, 2016) Çuğlan, Songül; Ekinci, Nihat; Yıldız, Azibe; Doğan, Zümrüt; Sapmaz, Hilal Irmak; Vardı, Nigar; Özyalın, Fatma; Bakırcı, Sinan; Çay, Mahmut; Köse, Evren; Türköz, Yusuf; Özbağ, DavutThis study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically.Öğe The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development(2017) Cuglan, Songul; Ekinci, Nihat; Yıldız, Azibe; Doğan, Zümrüt; Sapmaz, Hilal Irmak; Vardı, Nigar; Özyalın, FatmaThis study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically
