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Öğe Circle of Willis anomalies in stroke patients related with symptomatic carotid artery disease(Turkish Society of Cerebrovascular Diseases, 2012) Kamis?i S.; Kamişli Ö.; Teker U.; Kablan Y.; Saraç K.; Oz?can C.PURPOSE: Carotid artery disease, strokes due to hypoperfusion and embolism is composed of two mechanisms, the brain collateral circulation has an important role in the prevention of stroke. We investigated the Circle of Willis anomalies in the anterior circulation ischemic stroke related with carotid artery disease who had transient ischemic attack or ischemic stroke. MATERIAL AND METHODS: The patients whose circle of Willis anomalies in the digital subtraction angiographies fully evaluated in the first week of neurological symptoms included to this study. The relationship between the severity of symptomatic carotid artery stenosis was evaluated with variety of anomalies. Patients with stenosis and posterior cerebral artery first divison hypoplasia or aplasia in the same side had statistical lower stenosis percentages with patients those without this anomaly (p <0.013). CONCLUSION: The existence of Circle of Willis anomalies are as important as the degree of stenosis in symptomatic carotid artery disease. This situation can be considered when treatment decisions.Öğe Computed tomography guided percutaneous nephrostomy(2003) Baysal T.; Soylu A.; Saraç K.; Alkan A.; Dusak A.; Sarier M.Objectives: We investigated the value of computed tomography guided nephrostomies'in patients with absent or minimal pelvicaliceal dilatation and with different kidney anatomy and localization without using ultrasound and fluoroscopy. Material and Methods: We attempted 48 computed tomography guided nephrostomy placements in 40 patients. Both puncture of collecting system and placement of the catheters were made under computed tomography guidance. The Seldinger method was used in all procedures. Results: Percutaneous nephrostomies were successfully achieved in all patients without major complications. There were minimal dilatation of the pelvicaliceal systems in 28 (58.3%) of 48 nephrostomies. Four patients had obesity, and another 4 had rotation anomaly. One patient had both ectopic located and malrotated kidney. One patient had subcapsular haematoma and another one had retrorenal colon variation. Eighteen of the percutaneous nephrostomies were made intercostally. Single puncture was used in 35 (73%) and twice puncture were used in 13 (27%) procedures. The time necessary for the procedure ranged from 17-36 min (mean 28 min). Conclusion: Computed tomography guided percutaneous nephrostomy is a safe method with low rate of complications especially in patients with obesity, without pelvicaliceal dilatation or with minimal dilatation and patients with ectopic, malrotated kidneys and retrorenal colon variations.Öğe The effects of hesperidin on idiopathic pulmonary fibrosis evaluated by histopathologial-biochemical and micro-computed tomography examinations in a bleomycin-rat model(Scientific Publishers of India, 2016) Görmeli C.A.; Saraç K.; Çiftçi O.; Timurkaan N.; Malkoç S.Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive parenchymal lung disease. The pathology is characterized by recurrent injury to microscopic alveolar epithelial cells. These injuries activate inflammatory cells, resulting in the proliferation of fibroblasts and alveolar tissue damage. Interstitial inflammation, advanced oxidative stress, and abnormal antioxidant activity were demonstrated to be the main causes of IPF. Hesperidin (HP) is a bioflavonoid with anti-inflammatory, antioxidant, anticarcinogenic, and analgesic actions. HP may be able to prevent pulmonary fibrosis, and may ultimately lead to healthy lung function. We hypothesized that HP could prevent Bleomycin (BLC)- induced pulmonary fibrosis due to its biochemical, antioxidant, and anti-inflammatory properties and may ultimately lead to healthy lung function. Based on these findings, we hypothesized that HP could prevent BLC-induced pulmonary fibrosis due to its biochemical, antioxidant, and anti-inflammatory properties. The animals were divided into 4 groups with 14 rats per group. The experimental treatments were as follows: Control, BLC, HP, and BLC+HP. Six of the 14 lungs in each group were sent for micro- CT analysis. The remaining 8 lung specimens were harvested for histopathological and biochemical analyses. BLC-treated rats showed marked histopathological changes in the lungs. In these rats, thickening of interalveolar septa due to macrophage and lymphocyte infiltration, as well as fibroblast proliferation, were observed. Histopathological changes were less severe in the BLC+HP group compared with the BLC group. HP treatment led to a decrease in lipid peroxidation and an increase in antioxidant status compared with the BLC group. Also micro-CT showed a significant positive correlation with histopathological and biochemical results. To the best of our knowledge, this is the first study to evaluate the beneficial effects of HP against pulmonary fibrosis using histopathological, biochemical, and micro-CT analyses and HP successfully minimized the severity of BLC-induced lung injury, which was used as a model for IPF. © 2016, Scientific Publishers of India. All rights reserved.Öğe Magnetic resonance spectroscopy of brain in epileptic patients(2003) Saraç K.Magnetic resonance spectroscopy (MRS) reveals metabolic changes in the tissue, non-invasively. MRS was found to be useful in investigation of epileptic foci leading to epileptic discharges, the extent of the lesion and follow up of the anti-epileptic drug medication.Öğe MR spectroscopy in the differential diagnosis of focal brain lesions in neurofibromatosis type 1 patients(2003) Alkan A.; Kutlu R.; Sigirci A.; Baysal T.; Altinok T.; Dusak A.; Saraç K.PURPOSE: To determine the role of MR spectroscopy in the differential diagnosis of focal brain lesions in neurofibromatosis type 1. MATERIALS AND METHODS: Fifteen patients with neurofibromatosis type 1 were evaluated by routine MRI and single voxel MR spectroscopy (TE: 31). The posterior parietal white matter of 20 age-matched healthy volunteers constituted the control group. NAA/Cr, Cho/Cr and MI/Cr ratios were calculated and compared with the control group. RESULTS: A total of 58 focal brain lesions were detected by MR imaging. When patients with hamartomas and gliomas were compared with the control group, a decrease in the NAA/Cr ratio, and a significant increase in Cho/Cr and MI/Cr ratios were found. The decrease in the NAA/Cr ratio and the increase in Cho/Cr and MI/Cr ratios of gliomas were significant when compared with hamartomas. With MRI and MR spectroscopy findings, 52 hamartomas and 6 gliomas were detected. CONCLUSION: Since MR spectroscopy has the ability to detect cellular metabolic changes, it could provide additional information to MR imaging about the differential diagnosis and treatment planning of focal parenchymal lesions in neurofibromatosis type 1.Öğe Pregnant woman with subarachnoid hemorrhage and multiple intracranial aneurysms: A case report(Turkish Neurosurgical Society, 2006) Koçak A.; Ateş O.; Çayli S.R.; Saraç K.Aneurysmal subarachnoid haemorrhage (SAH) during pregnancy is rare but serious obstetric complication and may be confused with eclampsia. SAH occurs more often in primiparae and in the third trimester of pregnancy. The hemodynamic and endocrine changes play an important role in the growth and rupture of aneurysms. There are no differences in the clinical course of SAH among pregnant and non-pregnant patients. A 19-yr-old woman who was 34-weeks pregnant presented with an SAH, secondary to a ruptured left posterior communicating artery (L-PComA) aneurysm. The angiogram revealed multiple cerebral aneurysms. Following initial recovery, she subsequently underwent simultaneous elective caesarean section and clipping of the aneurysms. The management and pathogenesis of a ruptured aneurysm during pregnancy is discussed.Öğe Takayasu and giant cell (temporal) arteritis: The concealed realities(2004) Alat I.; Bahçeci F.; Taşkapan H.; Saraç K.[No abstract available]Öğe Teratoma presenting as a cystic lesion on the chest wall(2000) Soysal Ö.; Kutlu R.; Saraç K.; Aydin A.; Özen S.A 28-year-old woman presented with a rare case of chest-wall teratoma. Computed tomography of a cystic lesion located in the anterior chest wall revealed a hyperdense object with the appearance of a tooth. The cystic mass was totally excised via a chest-wall incision without thoracotomy. Pathologic examination showed a benign teratoma containing an immature tooth.
