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    2-methyl-1,4-benzodioxan-substituted bis(NHC)PdX2 complexes: Synthesis, characterization and the catalytic activity in the direct arylation reaction of some 2-alkyl-heterocyclic compounds
    (Springer, 2019) Gok, Yetkin; Aktas, Aydin; Sari, Yakup; Erdogan, Hulya
    Almost in all fields of chemistry, the C-C cross-coupling reactions such as the direct arylation reaction have attracted much attention and have advanced quickly in recent years due to the importance of environment-friendly properties. This study contains the synthesis of the 2-methyl-1,4-benzodioxan-substituted bis(NHC)PdX2 complexes and their catalytic activity in direct arylation reaction. The bis(NHC)PdX2 complexes have been prepared from the 2-methyl-1,4-benzodioxan-substituted Ag(I)NHC complexes via transmetallation method. The bis(NHC)PdX2 complexes have been characterized using H-1 NMR, C-13 NMR, FT-IR spectroscopy and elemental analysis techniques. The bis(NHC)PdX2 complexes have been examined as catalysts in the direct arylation reactions with 2-n-butylfuran, 2-n-butylthiophene and 2-isopropylthiazole, and have demonstrated excellent activity in these reactions.
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    4-Vinylbenzyl and 2-morpholinoethyl substituted ruthenium (II) complexes: Design, synthesis, and biological evaluation
    (Elsevier, 2020) Sari, Yakup; Gurses, Canbolat; Celepci, Duygu Barut; Kelestemur, Unzile; Aktas, Aydin; Yuksel, Sengul; Ates, Burhan
    Recently, the medical applications of organoruthenium complexes have attention attracted to organometallic chemists and biochemists. In this study, 4-vinylbenzyl and 2-morpholinoethyl substituted (NHC) Ru(II)(eta(6)-p-cymene) complexes were synthesized and in vitro DNA binding, cell cytotoxicity (anticancer activity) and genotoxicity properties were determined in order to understand the biological activities. These complexes have been prepared from the 4-vinylbenzyl and 2-morpholinoethyl substituted Ag(I) NHC complexes via transmetallation method. The characterization of the new (NHC)Ru(II)(eta(6)-p-cymene) complexes was performed by using H-1 NMR, C-13 NMR, FTIR spectroscopy and elemental analysis techniques. Also, molecular structure of complex 1b was obtained with single-crystal X-ray diffraction method. IC50 value of 1b against MCF-7 cell line was determined as 3.61 mu M and for 1b, an oxidation effect was observed in the concentrations higher than 50 mu g/mL. Comet assay unlike sister chromatid exchange (SCE) analysis data showed correlated results with cytotoxicity as well as DNA binding properties of the complexes. (C) 2019 Elsevier B.V. All rights reserved.
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    Benzimidazolium Salts Bearing 2-methyl-1,4benzodioxane Group: Synthesis, Characterization, Computational Studies, In vitro Antioxidant and Antimicrobial Activity
    (Biointerface Research Applied Chemistry, 2021) Albayrak, Sevil; Gok, Yetkin; Sari, Yakup; Tok, Tugba Taskin; Aktas, Aydin
    This study contains the synthesis of the 1-(2-methyl-1,4-benzodioxane)benzimidazole and 2-methyl-1,4-benzodioxane substituted benzimidazolium salts. The benzimidazolium salts were synthesized from the reaction of the 1-(2-methyl-1,4-benzodioxane)benzimidazole and various aryl chlorides. All compounds were characterized using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. The antioxidant properties of benzimidazolium salts were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and hydrogen peroxide scavenging ability assays. The compounds showed a moderate inhibitory effect on DPPH radical (The percent inhibition = 29.53-39.75). Also, the compounds exhibited significant H2O2 radical scavenging activity. Antimicrobial activities of the compounds were examined against nine bacterial strains and Candida albicans. All compounds displayed marked antimicrobial activity against tested microorganisms, particularly against Pseudomonas aeruginosa, Listeria monocytogenes, and C. albicans. From the computational perspective, benzimidazolium salts were also optimized at B3LYP / DMol3// DFT level using the Discovery Studio 2020 program. HOMO-LUMO analysis and molecular electrostatic potential surface (MESP) were exerted to examine the effects of benzimidazolium salts' electronic and structural properties.
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    Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity
    (Taylor & Francis Ltd, 2016) Sari, Yakup; Akkoc, Senem; Gok, Yetkin; Sifniotis, Vicki; Ozdemir, Ilknur; Gunal, Selami; Kayser, Veysel
    This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 24 h in the absence of light. The obtained complexes were identified and characterised by H-1 and C-13 NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity.
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    N-Propylphthalimide-substituted bis-(NHC)PdX2 complexes: synthesis, characterization and catalytic activity in direct arylation reactions
    (Springer, 2018) Erdogan, Hulya; Aktas, Aydin; Gok, Yetkin; Sari, Yakup
    Palladium-catalyzed direct arylation of heteroaromatics has become a popular method for producing carbon-carbon bonds via C-H bond activation. A wide diversity of heteroaromatics such as furan, thiophenes and thiazoles can be used for this reaction. This paper reports the synthesis of N-propylphthalimide-substituted bis-(NHC)PdX2 complexes (NHC = N-heterocyclic carbene), and their catalytic activity in direct arylation reactions. The complexes have been prepared from Ag(I)NHC precursors by transmetallation and characterized by spectroscopy and elemental analysis. The bis-(NHC)PdX2 complexes show excellent activity as catalysts in the direct arylation reactions of 2-n-butylfuran, 2-n-butylthiophene and 2-isopropylthiazole.
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    New 4-vinylbenzyl-substituted bis(NHC)-Pd(II) complexes: Synthesis, characterization and the catalytic activity in the direct arylation reaction
    (Elsevier Science Sa, 2018) Gok, Yetkin; Aktas, Aydin; Erdogan, Hulya; Sari, Yakup
    This study contains the synthesis of the new 4-vinylbenzyl substituted bis(NHC)-Pd(II) complexes and their catalytic activity in direct arylation reaction. The bis(NHC)-Pd(II) complexes have been prepared from Ag(I) NHC complexes by transmetallation method. The complexes have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy and elemental analysis techniques. Also, all the complexes showed excellent activity as catalysts in the direct arylation reaction. (C) 2017 Elsevier B.V. All rights reserved.
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    Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes
    (Wiley, 2018) Sari, Yakup; Aktas, Aydin; Taslimi, Parham; Gok, Yetkin; Gulcin, Ilhami
    The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 351.0-1269.9 nM against hCA I, 346.6-1193.1 nM against hCA II, and 19.0-76.3 nM against AChE. On the other hand, acetazolamide, a clinically used molecule, utilized as CA inhibitor, obtained a K-i value of 1246.7 nM against hCA I and 1407.6 nM against hCA II. Additionally, tacrine inhibited AChE and obtained a K-i value of 174.6 nM.
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    Synthesis, Characterization and Crystal Structure of New 2-Morpholinoethyl-Substituted Bis-(NHC)Pd(II) Complexes and the Catalytic Activity in the Direct Arylation Reaction
    (Springer, 2017) Sari, Yakup; Aktas, Aydin; Celepci, Duygu Barut; Gok, Yetkin; Aygun, Muhittin
    This paper contains the synthesis of the new 2-morpholinoethyl substituted bis-(NHC)Pd(II) complexes and their catalytic activity in direct arylation reaction. The new bis-(NHC)Pd(II) complexes have been prepared from Ag(I)NHC complexes by using transmetallation method. The new bis-(NHC)Pd(II) complexes have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy and elemental analysis techniques. Molecular and crystal structure of the complex 1a and its ligand (N-benzylbenzimidazole) were obtained by single crystal X-ray diffraction method. The new bis-(NHC)Pd(II) complexes exhibit activity in the reaction after being examined as catalysts in the direct arylation (C-H activation) reaction. [GRAPHICS] .