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    Glucose-insulin-potassium solution before cardiopulmonary bypass in coronary artery surgery
    (2000) Turkoz A.; Toprak H.I.; Sari S.; Ozturk E.; Durmus M.; Turkoz R.; Ersoy M.O.
    Glucose-insulin-potassium (GIK) solution has been advocated for the treatment of ischemic myocardium. This prospective, randomized clinical study was conducted to evaluate whether GIK solutions would cause benefit for the patients in addition to anterograd and retrograd combined blood cardioplegia undergoing coronary artery bypass grafting because of depressed left ventricle and unstable angina. The study group consisted of 33 patients with depressed left ventricle and unstable angina who underwent coronary artery bypass grafting, 2 patients were excluded from the study because of catheter dislocation. In 15 patients GIK solution (500 mL of 30 % dextrose, 70 units insuline, 80 mEq potassium) was given intravenously at 1 mL/kg per hour started with induction of anaesthesia, until the stage of cardiopulmonary bypass (CPB). Sixteen patients received ringer's lactate as the control group. The patients were analysed for hemodynamic changes, blood glucose and potassium levels. Pulmonary capillary wedge pressure, cardiac output, systemic vascular resistance, pulmonary vascular resistance were not different between two groups immediately before and after CPB. Blood glucose levels were not different between the two groups, but in both groups the levels increased after the end of the infusion of GIK solution, on the fifteenth minutes and at the end of the CPB. No differences were determined at the end of operation. There was no difference in serum potassium levels between the two groups, but potassium levels increased significantly during and immediately after CPB and decreased to the basal levels at the end of the operation in both groups. There was no significant difference between the groups in perioperative myocardial infarction, incidence of atrial and ventricular arrhythmias, times of ventilator support, length of stay in the intensive care unit and mortality. In this study, GIK therapy did not produce any additional positive hemodynamic effects and postoperative recovery from depressed left ventricle and urgent coronary artery bypass grafting.
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    Synthesis and cytotoxicity studies on new pyrazolecontaining oxime ester derivatives
    (University of Benin, 2021) Karakurt A.; Bozbey I.; Uslu H.; Sari S.; Ozdemir Z.; Salva E.
    Purpose: To synthesize a series of new 1-(2-naphthyl)-2-(1H-pyrazol-1-yl)ethanone oxime ester derivatives (5-12) with potential anticancer properties, and to determine their cytotoxic effects in mouse fibroblast and human neuroblastoma cell lines. Methods: The title compounds were obtained through sodium salt reaction of 1-(naphthalene-2-yl)-2-(1H-pyrazol-1-yl)etanone oxime (4) with various acyl chlorides. The cytotoxic effects were evaluated by MTS colorimetric assay, while physicochemical descriptors were calculated using QikProp software. Results: Most of the compounds showed approximately 50-60 % inhibition against SH-SY5Y neuroblastoma cells at 100 ?M. Of these, compound 7a was the most active combination with an IC50 value of 85.94 ?M. The toxic effect of the compounds on mouse fibroblast cell line was insignificant (p < 0.05) even when the dose was increased. The calculated physicochemical properties of the compounds were within drug-like chemical space. Conclusion: The synthesized oxime ester derivatives with pyrazole ring exhibit selective toxicity to neuroblastoma cells without affecting healthy mouse fibroblast cells. The compounds proved to be druglike while their pharmacokinetic features were also encouraging, and were in line with in silico predictions. © 2019 The authors.