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Öğe Anticonvulsant activity of some new Nafimidone derivatives: Effects on GABA metabolism(Wiley-Blackwell, 2015) Uyumlu, A. B.; Satilmis, B.; Batcioglu, K.; Alagoz, M. A.; Karakurt, A.; Genc, M. F.[Abstract Not Available]Öğe Effects of Calcium Channel Blockers on Trypsinogen Activation and Severity of Cerulein-induced Acute Pancreatitis in Rats(Wolters Kluwer Medknow Publications, 2018) Uyumlu, A.; Satilmis, B.; Batcioglu, K.; Karadag, N.; Genc, M.Acute pancreatitis is an inflammatory disease of the pancreas associated with high mortality but without a specific therapy. Intrapancreatic protease activation appears to be an early event in the development of acute pancreatitis but its association with pathogenesis has not been established. Recently it has been demonstrated that an enormous rise in the cytoplasmic Ca2+ levels of pancreatic acinar cells could be associated with the development of acute pancreatitis, thereby suggesting that Ca2+ channel could be a potential target for treatment. In this study, the protective effects of calcium channel blockers such as 2-aminoethoxydiphenyl borate, dantrolene and verapamil were investigated in cerulein-induced acute pancreatitis in vivo. Rats were divided into five groups. Group 1 (control), group 2 (cerulein, 100 mu g/kg), group 3 (cerulein+2-aminoethoxydiphenyl borate, mg/kg), group 4 (cerulein+dantrolene, 10 mg/kg) and group 5 (cerulein+verapamil, 2.5 mg/kg). Activities of amylase, lipase, cathepsin B, pancreatic secretory trypsin inhibitor, trypsin, levels of trypsinogen activation peptide and trypsinogen were measured addition to histological examination of the sections of pancreas. The results showed that cerulein increased the amylase, lipase and trypsin activities and trypsinogen activation peptide levels significantly. Administration of calcium channel blockers significantly protected the pancreas from histological damage (p<0.05). The results of this study demonstrated that calcium channel blockers can mitigate early protease activation and pancreas injury. It was suggested regulation of calcium channels would be relevant to maintain pancreatic acinar cell homeostasis and further research is necessary to understand the protective effects of calcium channel blockers.Öğe In vitro effects of neopterin on invasion, metastasis and proliferation of hepatocellular cancer cell lines(Lippincott Williams & Wilkins, 2023) Satilmis, B.; Sahin, T. T.; Otan, E.; Kutluturk, K.; Karakas, S.; Yilmaz, S.[Abstract Not Available]Öğe Investigation of in vivo radioprotective and in vitro antioxidant and antimicrobial activity of garlic (Allium Sativum)(Verduci Publisher, 2012) Batcioglu, K.; Yilmaz, Z.; Satilmis, B.; Uyumlu, A. B.; Erkal, H. S.; Yucel, N.; Gunal, S.OBJECTIVE, In this study, we aimed to assess the in vivo antioxidant potential via evaluating radioprotective effects in kidney and liver tissues of rats and in vitro antimicrobial and radical scavenger activity of garlic extract. MATERIALS AND METHODS, Thirty-two mature female Wistar rats were divided into four groups, each consisting of eight rats. Experimental groups were control group (1), GE group (2), irradiation group (3) and both GE and irradiation group (4). For the rats in two groups (group 3 and 4), irradiation was performed on a Cobalt-60 unit using a single fraction of 20 Gy. The GE was given to rats once a day during the month before irradiation and continued for five days after irradiation. The garlic cloves were peeled on crushed ice and 50 g of garlic was cut into small pieces and homogenized in 75 mL of 0.9% NaCl. The concentration of this garlic preparation was considered to be 500 mg/mL on the basis of weight of the starting material (0.5 g/mL). This extract was administered to rats by oral gavage. RESULTS, Our findings suggest that the use of garlic extract could be useful for addressing the limited therapeutic gain due to the radiation sensitivity of normal tissues adjacent to the tumour which are exposed to radiation, by strengthening the antioxidant system. In vitro and in vivo experiments seem to yield similar conclusions. CONCLUSIONS, It can be stated that garlic is may be recommended to be sufficiently included in the diets of radiotherapy patients considering its antioxidant and antimicrobial efficacy.Öğe Simultaneous determination of some phenolic compounds and antioxidant activity of Inula viscosa (L.) Aiton(Georg Thieme Verlag Kg, 2011) Gokbulut, A.; Sarer, E.; Satilmis, B.; Batcioglu, K.[Abstract Not Available]
