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    Analysis of the association between anxiety and depression levels and oxidative stress levels
    (2020) Savrun, Atakan; Savrun, Seyda Tuba; Gokcen, Emre; Aygun, Ali; Kasko Arici, Yeliz; Turkarslan, Murat
    Aim: There is a balance between reactive oxygen species (ROS) and antioxidant systems preventing them in the organism. In cases where this balance is impaired, molecular and cellular functions are negatively affected. Thiol-disulfide homeostasis (TDH) is also affected by this imbalance. It has been reported that the balance between oxidative and anti-oxidative systems is disrupted in individuals with psychiatric diseases such as anxiety and depression. Accordingly, it was aimed to determine the level of TDH in the serum of students who took the oral internship exam.Material and Methods: Volunteer fifth grade students of Medical Faculty, 19 male and 21 female, was included in the study. Of the students included in the study, Beck depression and Beck anxiety, albumin, ischemia-modified albumin (IMA), total thiol (SH + SS), native thiol (SH) and SS levels were measured and SS / SH + SS %, SH / SH + SS % and SS / SH % were calculated before and after the oral internship exam. These data were compared with the association between anxiety and depression level changes before and after the oral internship exam.Results: It was observed that the anxiety levels of the participants before the oral exam decreased in the period after the oral exam (p0.001). It was detected that the level of depression of the participants before the oral exam decreased after the oral exam (p0,05). Conclusion: Oral internship exam of Medical Faculty is a factor increasing anxiety and depression levels of the students. However, no association was found between oral internship exam and TDH parameters.
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    The value of laboratory markers in the differential diagnosis of acute vestibular syndrome
    (2021) Gokcen, Emre; Demir, Bilgehan; Savrun, Seyda Tuba
    Aim: Stroke is one of the leading and most challenging problems in distinguishing between central and peripheral causes of acute vestibular syndrome. This study aims to evaluate the potential utility of neutrophil to lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and gamma-glutamyl transferase (GGT) levels in the differential diagnosis of acute vestibular syndrome. Materials and Methods: This retrospective study included 152 patients diagnosed with vestibular neuritis (VN) and posterior circulation ischemic stroke (PCIS) within the scope of the isolated acute vestibular syndrome (AVS: vertigo, nystagmus, nausea-vomiting, postural instability, and intolerance of head movements). Of all these patients, we listed the ones having normal MRI findings and diagnosed with VN in the department of otorhinolaryngology. The diagnosis of stroke was made through neuroimaging methods (CT and MRI). NLR and GGT levels were compared among the patients diagnosed with VN and PCIS.Results: GGT, NLR, PLR levels were significantly higher in the patients with the PCIS group (p0.05). The AUC (area under the curve) and optimal cutoff values for NLR, PLR, and GGT were analyzed by ROC analysis. According to these results, the diagnostic value of NLR was higher in predicting stroke (AUC: 0.741; 95%CI: 0.652-0.829, p0.001)Conclusion: As a result, NLR, GGT, and PLR can be useful biomarkers for deciding in favor of stroke in the differential diagnosis of VN.