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    Anterior segment parameters and tear functions in patients with thalassemia major
    (2019) Bayramoglu, Sadik Etka; Aydogan, Gonul; Erdogan, Mehmet; Yildiz Ekinci, Dilbade; Sayin, Nihat
    Aim: To determine whether the biomicroscopic, topographic and biomechanical properties of the anterior segment and the tear function have changed in Thalassemia Major (TM) patients.Material and Methods: Eighty-eight eyes of patients with TM and 102 eyes of healthy controls paired with age, gender, and spherical equivalent were included in this cross- sectional case-control study. Biomicroscopic, topographic and biomechanical findings of anterior segment and Schirmer test measurements were compared between the two groups.Results: The mean age was found to be 15.11±6.01years in TM group, and 13.83±4.92 years in the control group (p=0.17). In 34 (38.63%) patients with TM, minor peripheral lens opacities were detected. Visual acuity was 20/20 in all patients with lens opacity. The mean iridocorneal angle (ICA) was 44.67±5.86 and the topographic anterior chamber depth (ACD) was 3.65±0.28 mm in the TM patients. Mean ICA was 48.78 ± 6.51 and topographic ACD was 3.76±0.30 mm in the control group (p0.001 and P=0.02 respectively). The mean Schirmer test result was 14.06±4.13 mm in patients with TM and 16.2±3.75 mm in the control group (p=0.001).Conclusion: In contrast to previous literature, we did not found any vision decreasing complications in the TM group. Although peripheral lenticular opacities were detected in some of the patients with TM, none of the patients had an anterior segment finding that could reduce visual acuity. Intraocular lens calculation formulas and surgical technique may be affected due to decreased ICA and ACD values in patients with TM.
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    Evaluation of macula, optic nerve and choroid in children with joint hypermobility
    (2019) Bayramoglu, Sadik Etka; Ekinci, Dilbade Yildiz; Sayin, Nihat; Aktay Ayaz, Nuray; Cakan, Mustafa
    Aim: To evaluate the macula, optic nerve and choroid layer by using Spectral Domain (SD)-OCT in children with joint hypermobility (JH)Material and Methods: In this cross-sectional case control study, 25 eyes of 25 children with JH diagnosed by rheumatological examination and 37 eyes of 37 healthy children were evaluated. Images were taken with SD -OCT. Two groups were compared in terms of mean central macular thickness, macular volume, ganglion cell complex (GCC) thickness, retina nerve fiber layer (RNFL) thickness and choroidal thickness (CT). CT was measured at the fovea; other CT measurements were taken 1,000 µm away from the fovea at the nasal and temporal regions and 1000 µm away from the optic disc at the nasal and temporal regions.Results: Mean subfoveal CT was 293.85±40.74 µm in JH group and 301.66±49.47 µm in the control group (p=0.548). There was no significant difference regarding to the mean macular and peripapillary CT values of all regions (P >0 .05 for all points). Moreover, the mean thicknesses of the RNFL, macula, and GCC did not differ between the two groups.Conclusion: This study showed that CT of children with JH is similar to those of healthy controls. In addition, there was no difference in macular thickness, RNFL and GCC between the two groups. These findings suggest that posterior segment structures are not affected in individuals with JH. Keywords: Joint hypermobility; choroid; macula; optic nerve.