Yazar "Sekerci, Guldeniz" seçeneğine göre listele

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    Cytotoxic and Genotoxic Effects of Nateglinide on A2780, LNCaP and Caco2 Cell Lines
    (Wiley, 2023) Oz, Samet; Yuksel, Furkan; Sekerci, Guldeniz; Tekin, Suat
    [Abstract Not Available]
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    Cytotoxic potential of silver, palladium, rhodium, ruthenium, and iridium complexes of a cycloheptyl-substituted lipophilic N-heterocyclic carbene ligand
    (Taylor & Francis Ltd, 2023) Karatas, Mert Olgun; Sekerci, Guldeniz; Tekin, Suat; Sandal, Suleyman; Kucukbay, Hasan
    Lipophilicity is a crucial parameter for cytotoxicity of metal complexes, in many cases associated with increased activity. In the present study, we synthesized a series of N-heterocyclic carbene (NHC) complexes of different metals with a lipophilic benzimidazolium chloride to investigate and compare their cytotoxicity. Rh- (4), Ru- (5), and Ir-NHC (6) complexes of a cycloheptyl-substituted benzimidazole-based NHC ligand (1) have been prepared by transmetalation reaction between Ag-NHC and the corresponding metal compound. The newly synthesized complexes have been characterized by NMR, IR, LC-MS spectroscopy, and elemental analyses. The anti-growth effects of the newly synthesized Rh-, Ru-, and Ir-NHC complexes and previously reported NHC precursor (1), Ag- (2), and Pd-NHC (3) complexes against human breast (MCF-7), colorectal (Caco-2), ovarian (A2780), and prostate (LNCaP) cancer cell lines have been investigated by MTT assay. The results revealed that the compounds provide stronger anti-growth effects against all cell lines compared to standard drug cisplatin. Among the compounds, benzimidazolium chloride, and Ag-NHC complex showed promising activities.
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    The Effect of Capsaicin on Oxidative Stress Parameters in Kidney in Sepsis Model Induced by Cecal Ligation and Puncture
    (Wiley, 2023) Firat, Semanur; Bircan, Burak; Cakir, Murat; Sekerci, Guldeniz; Oz, Samet
    [Abstract Not Available]
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    The Effect of TRPA1 Channel Agonist ASP7663 and Antagonist HC-030031 on Oxidative Stress Parameters in Renal Ischemia Reperfusion in Rats
    (Wiley, 2023) Firat, Semanur; Sekerci, Guldeniz; Cakir, Murat; Bircan, Burak; Oz, Samet
    [Abstract Not Available]
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    Effects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in rats
    (Springer, 2022) Sekerci, Guldeniz; Erden, Yavuz; Tekin, Suat
    Background Meteorin-like hormone (Metrnl) is a peptide secreted from the adipose tissue and modulates the whole-body energy metabolism. Metrnl release into the circulation is influenced by obesity, cold exposure, and exercise. Thyroid hormones also exert many of their effects on metabolism through uncoupling proteins (UCPs). This study aimed to determine effect of Metrnl on hypothalamo-hypophysier-thyroid axis and energy metabolism and reveal the possible involvement of UCPs in this process. Methods and results Fourty male Sprague-Dawley rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 nM Metrnl. Hypothalamus, muscle, white adipose tissue (WAT) and brown adipose tissue (BAT) samples were collected to detect thyrotropin-releasing hormone (TRH), and UCP1 and UCP3 protein levels by western blot analysis. Serum thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) hormone levels were determined by enzyme-linked immunosorbent assay. Central infusion of Metrnl caused significant increase in serum TSH, T3 and T4 levels compared to control (p < 0.05). After Metrnl treatment, there were significant increases in TRH in hypothalamus tissue, UCP1 in WAT and BAT; and UCP3 protein in the muscle tissue (p < 0.05). Conclusions The findings that Metrnl induced increases in the peripheral UCPs and hypothalamus-pituitary-thyroid axis hormones implicate a role for this hormone in body energy homeostasis through UCP-mediated mechanisms.
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    Investigation of anticancer effects of Meteorin like protein on different human cancer cell lines
    (2024) Sekerci, Guldeniz; Beytur, Leyla; Yuksel, Furkan; Tekin, Suat
    Aim: Cancer is one of the biggest health problems threatening humanity, and the fight against cancer continues with different methods worldwide. Despite advances in cancer prevention and treatment, the low success rate and tumor recurrence make the discovery of new alternative agents important. Adipokines are among those known to be associated with cancer. The relationship of the peptide-structured Meteorin like protein (Metrnl), a member of the adipokine family, discovered in 2012, with cancer remains a mystery. This study was conducted to examine the cytotoxic effects of Metrnl on human ovarian, prostate, colon and breast cancer cell lines. Materials and Methods: In the study, ovarian (A2780), human prostate (LNCaP), colon (Caco-2) and breast cancer (MCF-7) cell lines were used. After the cells were incubated with 1, 5, 10, 50, 100 and 200 ng/mL Metrnl for 24 h, the cytotoxicity level was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay method. determined. Comparisons between groups were made with the Kruskal Wallis H-Test. Results: Concentrations of Metrnl significantly reduced cell viability in A2780, LNCaP, Caco-2 and MCF-7 cell lines (p<0.05). Conclusion: These results show that Metrnl may have anticarcinogenic activity on A2780, LNCaP, Caco-2 and MCF-7 cells, but further studies are needed on this subject.
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    Investigation of Cytotoxic and Genotoxic Properties of Hybrid Compounds Containing New Generation Amino Acid Structures
    (Wiley, 2023) Sekerci, Guldeniz; Yuksel, Furkan; Tekin, Suat; Caliskan, Eray; Biryan, Fatih; Koran, Kenan; Sandal, Suleyman
    [Abstract Not Available]
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    Preparation, DFT calculations, docking studies, antioxidant, and anticancer properties of new pyrazole and pyridine derivatives
    (Wiley, 2022) Zebbiche, Zineddine; Sekerci, Guldeniz; Boulebd, Houssem; Kucukbay, Fatumetuzzehra; Tekin, Suat; Tekin, Zehra; Kucukbay, Hasan
    Seven novel pyrazole derivatives (4a-g) and four novel starting compounds incorporating substituted pyridine moieties were synthesized successfully. Cell viability assay for the tested compounds was performed, and the inhibitory concentrationlogarithmic 50 (LogIC(50)) values of the compounds were calculated after a 24-h treatment. Four of the examined compounds (3d, 3g, 4f, and 4g) showed comparable cytotoxic activity against CaCo-2 compared to the standard drug docetaxel at 0.1 and 1 mu M concentrations. Although the LogIC(50) of docetaxel was -0.678 mu M for CaCo-2 cells at 24 h, the LogIC(50) values of compounds were -0.794, -0.567, -0.657, and -0.498 respectively. Five of the compounds (2d, 2g, 3d, 3g and 4e) showed comparable cytotoxic activity against MCF-7 at 0.1 mu M concentration compared to docetaxel (p < 0.05). Docking studies revealed the compounds have a good affinity to the active site of the human topoisomerase II beta enzyme. The antioxidant capacities of all compounds were determined using both 1,1-diphenyl-2-picrylhydrazyl and metal chelation methods. Although the compounds did not show significant antioxidant activity, relatively effective are compounds 3c, 3d, and 3g, which are hydrazine derivatives with approximately 50% antioxidant activity of standard antioxidants at concentrations of 62.5 and 125 mu g/ml.
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    Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine-based tripeptides
    (Wiley, 2023) Caliskan, Eray; Kaplan, Alpaslan; Sekerci, Guldeniz; Capan, Irfan; Tekin, Suat; Erkan, Sultan; Koran, Kenan
    Peptides are one of the leading groups of compounds that have been the subject of a great deal of biological research and still continue to attract researchers' attention. In this study, a series of tripeptides based on tyrosine amino acids were synthesized by the triazine method. The cytotoxicity properties of all compounds against human cancer cell lines (MCF-7), ovarian (A2780), prostate (PC-3), and colon cancer cell lines (Caco-2) were determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay method, and % cell viability and logIC50 values of the compounds were calculated. Significant decreases in cell viability were observed in all cells (p < 0.05). The comet assay method was used to understand that the compounds that showed a significant decrease in cell viability had this effect through DNA damage. Most of the compounds exhibited cytotoxicity by DNA damage mechanism. Besides, their interactions between investigated molecule groups with PDB ID: 3VHE, 3C0R, 2ZCL, and 2HQ6 target proteins corresponding to cancer cell lines, respectively, were investigated by docking studies. Finally, molecules with high biological activity against biological receptors were determined by ADME analysis.