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Öğe Capsaicin Reduces Kidney Injury in a Sepsis Model Induced by Cecal Ligation and Puncture(Wiley, 2025) Bircan, Burak; Firat, Semanur; Cakir, Murat; Sekerci, Guldeniz; Oz, Samet; Aydin, Ali[No abstract available]Öğe Central Administration of Meteorin-Like Protein to Rats Activates Hypothalamus-Pituitary-Thyroid Axis Hormones and Increases Peripheral Uncoupling Proteins(Wiley, 2022) Sekerci, Guldeniz; Erden, Yavuz; Tekin, Suat[Abstract Not Available]Öğe Cytotoxic and Genotoxic Effects of Nateglinide on A2780, LNCaP and Caco2 Cell Lines(Wiley, 2023) Oz, Samet; Yuksel, Furkan; Sekerci, Guldeniz; Tekin, Suat[Abstract Not Available]Öğe Cytotoxic potential of silver, palladium, rhodium, ruthenium, and iridium complexes of a cycloheptyl-substituted lipophilic N-heterocyclic carbene ligand(Taylor & Francis Ltd, 2023) Karatas, Mert Olgun; Sekerci, Guldeniz; Tekin, Suat; Sandal, Suleyman; Kucukbay, HasanLipophilicity is a crucial parameter for cytotoxicity of metal complexes, in many cases associated with increased activity. In the present study, we synthesized a series of N-heterocyclic carbene (NHC) complexes of different metals with a lipophilic benzimidazolium chloride to investigate and compare their cytotoxicity. Rh- (4), Ru- (5), and Ir-NHC (6) complexes of a cycloheptyl-substituted benzimidazole-based NHC ligand (1) have been prepared by transmetalation reaction between Ag-NHC and the corresponding metal compound. The newly synthesized complexes have been characterized by NMR, IR, LC-MS spectroscopy, and elemental analyses. The anti-growth effects of the newly synthesized Rh-, Ru-, and Ir-NHC complexes and previously reported NHC precursor (1), Ag- (2), and Pd-NHC (3) complexes against human breast (MCF-7), colorectal (Caco-2), ovarian (A2780), and prostate (LNCaP) cancer cell lines have been investigated by MTT assay. The results revealed that the compounds provide stronger anti-growth effects against all cell lines compared to standard drug cisplatin. Among the compounds, benzimidazolium chloride, and Ag-NHC complex showed promising activities.Öğe Eco-friendly synthesis of α-aminophosphonates using ultrasound irradiation: In vitro pharmacological studies and molecular docking approach(Elsevier, 2026) Badaoui, Kawther; Sehout, Imene; Sekerci, Guldeniz; Keskin, Tuba; Tekin, Suat; Hamlaoui, Ikram; Kucukbay, HasanA series of novel alpha-aminophosphonates 4a-m have been successfully synthesized via Kabachnik-Fields reaction under ultrasound irradiation and in the presence of acetylsalicylic acid as catalyst with yields ranging 69-87 %. All compounds were characterized by 1H, 13C, 31P, FTIR and elemental analysis. Anticancer activity was evaluated using three cancer cell lines (MCF-7, A2780, Caco-2). Compounds 4k, 4h and 4e exhibited good cytotoxic activity against MCF-7. The in vitro antioxidant activity of the synthesized molecules was evaluated by four complementary methods (DPPH, ABTS, FRAP and Phenanthroline). Compound 4c and 4f showed high antioxidant capacity at ABTS scavenging assay, while compounds 4a, 4b, 4c, 4d, 4e and 4f showed high antioxidant capacity at Phenanthroline assay. The target molecules showed moderate antifungal activity against the phytopathogenic strain Fusarium oxysporum f.sp. lycopersici (FOL). Compounds 4e, 4h, and 4k, that showed the best the highest activity against breast cancer (MCF-7), were further analyzed through molecular docking to investigate their modes of interaction with two enzymes implicated in this cancer.Öğe The Effect of Capsaicin on Oxidative Stress Parameters in Kidney in Sepsis Model Induced by Cecal Ligation and Puncture(Wiley, 2023) Firat, Semanur; Bircan, Burak; Cakir, Murat; Sekerci, Guldeniz; Oz, Samet[Abstract Not Available]Öğe The Effect of TRPA1 Channel Agonist ASP7663 and Antagonist HC-030031 on Oxidative Stress Parameters in Renal Ischemia Reperfusion in Rats(Wiley, 2023) Firat, Semanur; Sekerci, Guldeniz; Cakir, Murat; Bircan, Burak; Oz, Samet[Abstract Not Available]Öğe Effects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in rats(Springer, 2022) Sekerci, Guldeniz; Erden, Yavuz; Tekin, SuatBackground Meteorin-like hormone (Metrnl) is a peptide secreted from the adipose tissue and modulates the whole-body energy metabolism. Metrnl release into the circulation is influenced by obesity, cold exposure, and exercise. Thyroid hormones also exert many of their effects on metabolism through uncoupling proteins (UCPs). This study aimed to determine effect of Metrnl on hypothalamo-hypophysier-thyroid axis and energy metabolism and reveal the possible involvement of UCPs in this process. Methods and results Fourty male Sprague-Dawley rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 nM Metrnl. Hypothalamus, muscle, white adipose tissue (WAT) and brown adipose tissue (BAT) samples were collected to detect thyrotropin-releasing hormone (TRH), and UCP1 and UCP3 protein levels by western blot analysis. Serum thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) hormone levels were determined by enzyme-linked immunosorbent assay. Central infusion of Metrnl caused significant increase in serum TSH, T3 and T4 levels compared to control (p < 0.05). After Metrnl treatment, there were significant increases in TRH in hypothalamus tissue, UCP1 in WAT and BAT; and UCP3 protein in the muscle tissue (p < 0.05). Conclusions The findings that Metrnl induced increases in the peripheral UCPs and hypothalamus-pituitary-thyroid axis hormones implicate a role for this hormone in body energy homeostasis through UCP-mediated mechanisms.Öğe Exploring the anticancer potential of new 3-cyanopyridine derivatives bearing N-acylhydrazone motif: Synthesis, DFT calculations, cytotoxic evaluation, molecular modeling, and antioxidant properties(Wiley, 2024) Kadi, Ibtissem; Sekerci, Guldeniz; Boulebd, Houssem; Zebbiche, Zineddine; Tekin, Suat; Benarous, Khedidja; Serseg, Talia3-Cyanopyridine derivatives are known for exhibiting excellent anticancer activity due to their strong capability to inhibit various biological targets, including Pim-1 kinase, survivin, and tubulin polymerization. On the other hand, N-acylhydrazones (NAH) are known to be a very versatile motif in medicinal chemistry and drug design. Based on these data, we report in this paper, the synthesis of novel 3-cyanopyridines incorporating N-acyl hydrazine scaffold, the evaluation of their cytotoxicity on the breast (MCF-7) and ovarian (A-2780) cancer cell lines and their antioxidant properties. Excluding 4a and 4d, all tested molecules exhibited high cytotoxicity against A-2780, with IC50 values ranging from 1.14 to 1.76 mu M. Conversely, only four molecules 3d, 4b, 4c, and 4d demonstrated cytotoxicity against MCF-7, with IC50 values ranging from 1.14 to 3.38 mu M. On the other hand, all the tested molecules exhibited a moderate antioxidant capacity in both the DPPH and metal chelation assays. Docking and molecular dynamics studies revealed that 2d, 3d, and 4d are potential inhibitors of tubulin and the oe strogen receptor, which may explain their high cytotoxicity. These results are promising to study these newly synthesized 3-cyanopyridine-N-acylhydrazones in depth for use as potential anticancer candidates. A series of novel N-acetylhydrazone motifs-containing 3-cyanopyridine derivatives were synthesized, and their anticancer properties against MCF-7 and A2780 cancer cell lines, along with their antioxidant capacities, were investigated under in vitro conditions. Additionally, density functional theory (DFT) calculations and molecular modeling were conducted in silico. imageÖğe Inhibition of Transient Receptor Potential Ankyrin 1 Channels Reduces Renal Ischemia Reperfusion Injury(Wiley, 2025) Firat, Semanur; Cakir, Murat; Bircan, Burak; Aydin, Ali; Sekerci, Guldeniz; Oz, Samet[No abstract available]Öğe Investigation of anticancer effects of Meteorin like protein on different human cancer cell lines(2024) Sekerci, Guldeniz; Beytur, Leyla; Yuksel, Furkan; Tekin, SuatAim: Cancer is one of the biggest health problems threatening humanity, and the fight against cancer continues with different methods worldwide. Despite advances in cancer prevention and treatment, the low success rate and tumor recurrence make the discovery of new alternative agents important. Adipokines are among those known to be associated with cancer. The relationship of the peptide-structured Meteorin like protein (Metrnl), a member of the adipokine family, discovered in 2012, with cancer remains a mystery. This study was conducted to examine the cytotoxic effects of Metrnl on human ovarian, prostate, colon and breast cancer cell lines. Materials and Methods: In the study, ovarian (A2780), human prostate (LNCaP), colon (Caco-2) and breast cancer (MCF-7) cell lines were used. After the cells were incubated with 1, 5, 10, 50, 100 and 200 ng/mL Metrnl for 24 h, the cytotoxicity level was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay method. determined. Comparisons between groups were made with the Kruskal Wallis H-Test. Results: Concentrations of Metrnl significantly reduced cell viability in A2780, LNCaP, Caco-2 and MCF-7 cell lines (p<0.05). Conclusion: These results show that Metrnl may have anticarcinogenic activity on A2780, LNCaP, Caco-2 and MCF-7 cells, but further studies are needed on this subject.Öğe Investigation of Cytotoxic and Genotoxic Properties of Hybrid Compounds Containing New Generation Amino Acid Structures(Wiley, 2023) Sekerci, Guldeniz; Yuksel, Furkan; Tekin, Suat; Caliskan, Eray; Biryan, Fatih; Koran, Kenan; Sandal, Suleyman[Abstract Not Available]Öğe Investigation of the Effects of Vildagliptin on Cancer Cell Lines: An In Vitro Study(Wiley, 2025) Sekerci, Guldeniz; Keskin, Tuba; Tekin, Suat[No abstract available]Öğe JAK inhibitor Baricitinib Attenuates Kidney Injury in Sepsis Model Induced by Cecal Ligation and Puncture(Wiley, 2025) Tarakci, Betul; Firat, Semanur; Cakir, Murat; Bircan, Burak; Sekerci, Guldeniz; Aydin, Ali[No abstract available]Öğe Loratadine Reduces Cell Viability in Different Types of Human Cancer Cell Lines(Wiley, 2025) Keskin, Tuba; Sekerci, Guldeniz; Tekin, Suat[No abstract available]Öğe Phoenixin-14 Administration Acts Protective Role in Rats with Experimental Acute Kidney Injury Model(Wiley, 2025) Oz, Samet; Bahar, Mehmet Refik; Sekerci, Guldeniz; Cetin, Asli; Tekin, Suat[No abstract available]Öğe Preparation, DFT calculations, docking studies, antioxidant, and anticancer properties of new pyrazole and pyridine derivatives(Wiley, 2022) Zebbiche, Zineddine; Sekerci, Guldeniz; Boulebd, Houssem; Kucukbay, Fatumetuzzehra; Tekin, Suat; Tekin, Zehra; Kucukbay, HasanSeven novel pyrazole derivatives (4a-g) and four novel starting compounds incorporating substituted pyridine moieties were synthesized successfully. Cell viability assay for the tested compounds was performed, and the inhibitory concentrationlogarithmic 50 (LogIC(50)) values of the compounds were calculated after a 24-h treatment. Four of the examined compounds (3d, 3g, 4f, and 4g) showed comparable cytotoxic activity against CaCo-2 compared to the standard drug docetaxel at 0.1 and 1 mu M concentrations. Although the LogIC(50) of docetaxel was -0.678 mu M for CaCo-2 cells at 24 h, the LogIC(50) values of compounds were -0.794, -0.567, -0.657, and -0.498 respectively. Five of the compounds (2d, 2g, 3d, 3g and 4e) showed comparable cytotoxic activity against MCF-7 at 0.1 mu M concentration compared to docetaxel (p < 0.05). Docking studies revealed the compounds have a good affinity to the active site of the human topoisomerase II beta enzyme. The antioxidant capacities of all compounds were determined using both 1,1-diphenyl-2-picrylhydrazyl and metal chelation methods. Although the compounds did not show significant antioxidant activity, relatively effective are compounds 3c, 3d, and 3g, which are hydrazine derivatives with approximately 50% antioxidant activity of standard antioxidants at concentrations of 62.5 and 125 mu g/ml.Öğe Protective Effect of Transient Receptor Potential Ankyrin 1 Inhibition on Renal Ischemia Reperfusion Injury in Rats(Wiley, 2025) Cakir, Murat; Aydin, Ali; Firat, Semanur; Sekerci, Guldeniz; Bircan, Burak; Oz, SametThe transient receptor potential ankyrin 1 (TRPA1) channels, characterized as nonselective cation channels with permeability to calcium ions (Ca2 +), are part of the extensive family of transient receptor potential (TRP) channels. Research has demonstrated that TRPA1 channels function as sensors for oxidative stress in the renal tubules. Additionally, TRPA1 expression has increased in renal tissue following ischemia-reperfusion (IR). There is also a significant correlation between IR-induced renal injury and TRPA1 expression. This study investigated the effects of selective TRPA1 agonist ASP7663 and selective TRPA1 antagonist HC-030031 on renal IR injury. A total of 40 rats were divided into four groups: control, IR, IR+ASP7663, and IR + HC-030031. The rat kidneys were exposed to 45 min of ischemia, followed by 24 h of reperfusion. TRPA1 agonist ASP7663 and selective TRPA1 antagonist HC-030031 were administered intraperitoneally to the treatment groups with renal IR. HC-030031 administration reduced the elevated kidney injury molecule-1 (KIM-1), blood urea nitrogen (BUN), and creatinine (Cre) caused by renal IR. HC-030031 administration reduced the increased histopathological damage in renal tissue due to IR. It also reduced renal tissue interleukin-1beta (IL-1 beta), interleukin-6 (IL-6), toll-like receptor-4 (TLR-4), phosphorylated-NF-kappa B, phosphorylated-I kappa B-alpha, tumor necrosis factor-alpha (TNF-alpha), and caspase-3 levels. In this study, TRPA1 antagonist HC-030031 showed a protective behavior on renal IR injury by averting inflammation and apoptosis. After further studies, TRPA1 inhibition may be a new treatment strategy to prevent renal IR injury.Öğe Protective Effects of Phoenixin-14 Administration Against Renal Ischemia/Reperfusion Injury in Rats(Wiley, 2025) Oz, Samet; Bahar, Mehmet Refik; Sekerci, Guldeniz; Taslidere, Asli; Tekin, SuatPhoenixin (PNX), identified in the rat hypothalamus in 2013, has two bioactive isoforms with 14 and 20 amino acids. Initially studied for its role in reproductive regulation, research has since shown that PNX also prevents visceral pain, enhances memory, and aids heart tissue recovery. However, its role in kidney tissue remains unclear. Due to its antioxidant properties, PNX may help reduce oxidative stress and cellular damage in organs. This study was designed to determine the potential protective effects of Phoenixin-14 (PNX-14) against renal ischemia/reperfusion (I/R)-induced injury in rats. 40 male Wistar Albino rats were divided into four groups: Control, I/R, PNX-14 (50 mu g/kg), and PNX-14 (100 mu g/kg) (n = 10). All groups except the control group underwent 45 min of bilateral ischemia followed by 24 h of reperfusion. PNX-14 (50 and 100 mu g/kg, intraperitoneally) was administered 1 h before induction of ischemia. Both doses of PNX-14 reduced the levels of acute kidney injury markers (blood urea nitrogen and creatinine) in blood tissue (p < 0.05). PNX-14 increased the activity of antioxidant enzymes (superoxide dismutase and catalase) and the levels of glutathione, while reducing malondialdehyde (p < 0.05). Histological evaluation of the I/R group revealed significant histopathological findings, and it was found that PNX-14 administration improved these histological damages (p < 0.05). These results suggest that PNX-14 provides protection against renal injury induced by I/R. After further studies, PNX-14 may be a new therapeutic strategy to prevent renal I/R injury.Öğe Protective Effects of TRPV1 Agonist Capsaicin in Sepsis-Induced Acute Kidney Injury in Rats(Wiley, 2025) Bircan, Burak; Cakir, Murat; Aydin, Ali; Firat, Semanur; Sekerci, Guldeniz; Samet, Oz; Tekin, SuatTransient receptor potential vanilloid-1 (TRPV1) channels have been shown to be present in many tissues, including the kidney. Previous studies have reported that TRPV1 activation has anti-inflammatory and renoprotective effects. In this study, we investigated the effects of TRPV1 agonist capsaicin on acute kidney injury (AKI) in a rat sepsis model induced by cecal ligation and puncture (CLP). Rats were divided into control, CLP and treatment groups in which 3 different doses of capsaicin (2, 6 and 30 mg/kg) were administered with CLP administration. Kidney tissues and sera from animals 24 h after CLP were analyzed. Histopathological examinations have shown that kidney damage occurs due to sepsis. TLR4/NF-kappa B activity, proinflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha), caspase-3, caspase-8 and malondialdehyde levels increased in renal tissue due to sepsis. Serum levels of IL-1 beta, TNF-alpha and renal damage biomarkers (BUN, CRE, IL-18 and NGAL) increased due to sepsis. Capsaicin administration dose-dependently reversed sepsis-induced pathological changes in the kidney and serum. Our findings suggest that the TRPV1 agonist capsaicin has renoprotective effects in sepsis-induced AKI by reducing inflammation, oxidative damage and apoptosis. TRPV1 activation may be a promising therapeutic strategy to ameliorate sepsis-induced kidney and other organ damage.
