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    Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study
    (Taylor & Francis Inc, 2018) Erdemli, Mehmet Erman; Salmas, Ramin Ekhteiari; Durdagi, Serdar; Akgul, Hasan; Demirkol, Mehmet; Aksungur, Zeynep; Selamoglu, Zeliha
    In the present study, the changes that occur in rat liver tissue as a result of the use of grape seed extract (GSE) and low level laser therapy (LLLT) in intraoral wound (IW) healing are analyzed using biochemical parameters. Diode laser application groups received 8J/cm(2) dose LLLT once a day for 4days (810nm wavelength, continuous mode, 0.25W, 9s). As a result of the biological parameter analysis, it was determined that the oxidative damage caused by the IWs and recovery period on 7th and 14th days could be substantially removed with GSE applications that have antioxidant capacity especially in rat liver tissue. In addition, the active compound of grape seed, catechin is studied in the active site of glycogen synthase kinase 3 (GSK3) target using molecular modeling approaches. Post-processing molecular dynamics (MD) results for catechin is compared with a standard GSK3 inhibitor. MD simulations assisted for better understanding of inhibition mechanism and the crucial amino acids contributing in the ligand binding. These results along with a through free energy analysis of ligands using sophisticated simulations methods are quite striking and it suggests a greater future role for simulation in deciphering complex patterns of molecular mechanism in combination with methods for understanding drug-receptor interactions.
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    The effects of grapeseed extract and low level laser therapy administration on the liver in experimentally fractured mandible
    (2017) Erdemli, Mehmet Erman; Akgul, Hasan; Ege, Bilal; Aksungur, Zeynep; Gozukara Bag, Harika; Selamoglu, Zeliha
    Aim: The present study investigated the changes in the liver tissues of rats with experimentally fractured mandible following the use of Grape Extract (GSE) and Low Level Laser Therapy (LLLT) in healing the fracture in dentistry. Materials and Methods: 60 adult male Wistar Albino rats were randomly assigned to 5 main groups (Control, Fractured Mandible (FM), FM + GSE, FM + LLLT, FM + LLLT + GSE), and then these groups were divided into two groups of 7 and 21 days (n = 6). A vertical fracture line passing through the molar teeth was formed in the right mandibles of all subjects except for these in the control group, and the fracture was internally fixed with a four-hole microplate and four micro-screws. Malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) activities were analyzed to determine the changes caused by GSE and LLLT administration in rat liver tissues in fractured mandibles. Results: It was determined that MDA and SOD levels in FM group and GSH and CAT activity levels in FM + GSE group and MDA levels in FM + LLLT group and GSH and CAT levels in FM + GSE + LLLT group increased statistically significantly to the control group on days 7 and 21. Conclusion: Biochemical parameters were investigated on the 7th and the 21st days, and it was determined that the oxidative damage caused by mandibular defects could be eliminated substantially in the rat liver especially with the administration of grapeseed that has antioxidant capacity
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    The Effects on Oxidative Systems in Liver Tissues of Systemic Ozone Application after Critical Size Hone Defect Surgery in Rat Mandibles
    (Ars Docendi, 2019) Erdemli, Mehmet Erman; Akgul, Hasan; Selamoglu, Zeliha
    Examination of the changes that non-toxic doses of antioxidant action ozone used in increasing osteogenic activity by dentists causes on rat liver tissues. The effects of ozone applications that are significant in mandibular bone defect therapies and oral and maxillofacial surgery practice on oxidant / antioxidant system in rat liver tissues are investigated by analyzing malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) parameters. While there were statistically significant reductions in MDA levels and SOD activities after 15 and 45 days long ozone applications on critical mandibular bone defect induced rat livers, statistically significant increases were observed in GSH levels and CAT activities (P <= 0.05). This is the first study where the effects of ozone therapies used in treatment of mandibular bone defect on liver tissue oxidant / antioxidant system in rats are scrutinized with the analysis of biochemical parameters. It was determined that ozone applications did not have any negative effects on liver tissue oxidant / antioxidant system and concurrently had positive effects on liver antioxidant system and to reveal the biochemical mechanism completely, further studies are needed.
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    ROLE OF PROPOLIS ON OXIDATIVE STRESS IN VARIOUS TISSUES OF FISH
    (Parlar Scientific Publications (P S P), 2014) Aldemir, Osman Selcuk; Selamoglu, Zeliha; Gulhan, Mehmet Fuat; Cakir, Oguz; Ozdemir, Ilknur; Dastan, Sevgi Durna; Dogan, Husnu
    The aim of this study was to investigate the therapeutic effects of propolis on biochemical parameters in tissues of rainbow trout (Oncorhynchus mykiss) exposed to cypermethrin. Cypermethrin is a potential toxic pollutant that directly threats the aquatic ecosystems and environment. Sublethal cypermethrin concentration of 0.0082 ppm was applied to the fish for 96 h. Propolis is a natural product collected from plants by honey bees. Its polyphenolic components, caffeic acid derivatives and flavonoids in particular, are matter of interest because of their strong antioxidant properties. Therapeutic concentration of propolis has been determined as 10 ppm in a previous study. Herein, malondialdehyde (MDA) levels and catalase (CAT) activities were determined in spleen and heart tissues of rainbow trouts. Results showed that CAT activities and MDA levels increased (P <= 0.001) in tissues of fish exposed to cypermethrin compared to control group. CAT activities and MDA levels in the tissues of fish decreased in cypermethrin+propolis group (P <= 0.001) compared to cypermethrin group. Propolis (10 ppm) on the tissues of the rainbow trout showed significant therapeutic effects. Propolis may serve as an antitoxic agent against pesticide toxicity to aquatic animals.