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    Clinicopathological characteristics and prognosis of gastric adenocarcinoma patients
    (2019) Senel, Fatma
    Aim: The purpose of the study was to investigate the effective prognostic factors on recurrence and mortality in patients with differential thyroid cancer. Material and Methods: The effects of various parameters of demographic characteristics, the admission symptoms, physical examination, laboratory findings, pathological examination, and surgical method of 184 patients, who underwent surgery due to differential thyroid cancer between January 1986 and December 2009 in 4th General Surgical Clinic of Ankara Numune Training and Research Hospital, on prognosis were examined. The information of the patients was obtained from automation system of the hospital and Thyroid Cancer Information and Follow-Up Form of 4th General Surgical Clinic of Ankara Numune Training and Research Hospital.Results: The sample group consisted of 172 papillary cancer patients and 12 follicular cancer patients. The mean age of the patients was 45.4 years (15-78). There were 159 (86.4%) female patients and 25 (13.6%) male patients. The mean follow-up period of 161 (87.5%) patients, who were followed up regularly, was 73.26 months (1-231). The mean recurrence period was 77.66 months (1-150). Mortality was observed in eight (4.3%) patients during their follow-up period. The mean life expectancy of those who died was 66.87 months (1-150 months).* Single variable analysis revealed that the T stage and pathologic final stage were effective on recurrence. Painful nodules and palpable lymph nodes in the neck and the papillary histological malignant subtype variant, as well as the presence of vascular and adjacent organ invasion, multicentricity, T stage, the lymph nodes, distant metastasis, and the clinical stage during the admission were identified to be effective on mortality.Conclusion: The risk of recurrence is high in DTC patients with high T stage and advanced pathologic stage. The rate of survival of those with multicentric tumors and advanced pathologic stage is low. Therefore, it is important for patients to be followed up closely within a postoperative multidisciplinary context.Keywords: Differential; thyroid; cancer; recurrence; mortality.
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    Clinicopathological features of papillary thyroid carcinoma: A single-centre experience in Turkey
    (2020) Senel, Fatma
    Aim: The goal of this study was to determine the incidence of papillary thyroid carcinoma (PTC) at our centre and examine the clinicopathological features of the tumours.Material and Methods: The study included 823 patients who underwent thyroidectomies in our centre between January 2013 and June 2017 and were examined histopathologically at the Pathology Clinic. We examined their demographic characteristics, preoperative diagnoses, operative procedures, FNAC diagnoses, histopathological characteristics, and postoperative prognoses.Results: Out of the 823 patients, 16.3% were diagnosed with malignancy. Of these diagnoses, 89.6% were papillary carcinomas, 3.7% were follicular carcinomas, 3% were lymphomas, 1.5% was medullary carcinomas, 1.5% were anaplastic carcinomas, and 0.7% were poorly differentiated carcinomas. The rate of PTC incidence in thyroidectomy specimens was 14.6%. In our cases, the multifocality rate of tumours was 31.7%, and the rate of bilateral disease was 24.2%. Neck dissection was performed in 11 PTC patients. Seven of these patients (5.8%) had lymph node metastasis. Of all patients, 46.7% received postoperative radioactive iodine (RAI) therapy. No recurrence or distant metastasis was detected in any of the cases.Conclusion: PTC is the most common type of thyroid carcinoma at our centre. Fine-needle aspiration cytology (FNAC) is valuable for diagnosing classical PTC. Because of the high occurrence of bilateral and multifocal disease in PTC, performing total thyroidectomy is appropriate. Long-term life expectancy is good for these patients.
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    Histopathological features of salivary gland tumors: A single-center experience
    (2020) Senel, Fatma; Karaman, Hatice
    Aim: This study’s goal was to retrospectively evaluate cases who were diagnosed with primary salivary gland tumors in our center, to examine the histopathological features of these tumors, and to reveal difficulties in the differential diagnosis. Material and Methods: Sixty-four patients who applied to our center with complaints of pain and swelling in the salivary gland region between January 2016 and February 2020 and who were diagnosed with salivary gland tumor in our pathology clinic were analyzed retrospectively. The age and sex of the patients, the salivary gland where the tumor was located, and the histopathological examination results were recorded. Results: The age range of the patients was 13-89 years, and 57.8% and 42.2% of 64 patients in total were female and male, respectively. While 86% of the patients had tumors located in the parotid gland, 14% of them had tumors located in the submandibular gland. According to the histopathological examination results, 89% and 11% of the patients had benign and malignant tumors, respectively. While the most common tumor among benign tumors was a pleomorphic adenoma at a rate of 57.8%, the most common tumor among malignant tumors was a mucoepidermoid carcinoma at a rate of 4.7%. Conclusion: In the present study, salivary gland tumors were more common in females. The majority of salivary gland tumors were located in the parotid gland, and the majority of them were benign. The majority of tumors located in the submandibular gland were malignant.
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    The role of fine-needle aspiration cytology in papillary thyroid carcinoma cases
    (2020) Senel, Fatma; Karaman, Hatice
    Aim: Thyroid diseases are among the most common diseases in our country and all over the world. Fine-needle aspiration cytology (FNAC) is a useful and simple method for diagnosing papillary thyroid carcinoma (PTC) and can be used as a first step. The aim of this study was to determine the diagnostic value of FNAC in PTC cases by comparing FNAC and histopathological findings and to present our experiences.Material and Methods: This retrospective study evaluates 800 cases who underwent thyroidectomies in our center and had a histopathological examination in the pathology clinic. The age, gender, operation procedure, FNAC findings, and histopathological results of PTC cases were recorded.Results: Of 800 thyroidectomy cases, 119 (14.9%) were diagnosed with PTC; 50 (42%) were classic PTC cases and 69 (58%) were papillary microcarcinoma (PMC) cases. Of the 50 classic PTC cases, 45 had FNAC, which were included in the study. Of these, the positivity rate was 84.5% when atypia of undetermined significance (AUS) cases and suspected malignancies were included with those diagnosed with malignancy. Of 45 PTC cases, 3(6.6 %) were inadequate, 4 (8.9 %) were benign, 7 (15.5 %) were AUS, 4 (8.9 %) were suspected of follicular neoplasm, 18 (40 %) were suspected of malignancy, and 9 (20 %) were diagnosed as malignant. Conclusion: In our study, the false positivity rate was 0.5% and the false negative rate was 8.9%. Carcinomas in the follicular pattern can only be diagnosed by histopathological approach. FNAC is currently the gold standard for diagnosing PTC. However, a benign FNAC diagnosis should be viewed with caution as false-negative results do occur. When a benign FNAC diagnosis is given, surgery is necessary if there is any clinical suspicion of malignancy.