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Öğe Amyloidosis cutis dyschromica: A case treated with acitretin(Wiley, 2005) Ozcan, A; Senol, M; Aydin, NE; Karaca, SWe report a case of amyloidosis cutis dyschromica with diffuse postinflammatory-type hypo- and hyperpigmentation all over the body. The diagnosis was confirmed with routine light microscopic and immunohistochemical staining methods. The patient was treated with acitretin with a good response.Öğe Body odor in dermatologic diagnosis(Excerpta Medica Inc, 1999) Senol, M; Fireman, PPatients with an unpleasant body odor often consult dermatologists. A dermatologist needs to become familiar with the occurrence and significance of medically related odors. Although body odor may be essentially physiological, and problems with body malodor are paid little attention, they can cause many personal troubles and may induce a variety of psychosocial disturbances. Body odor in general is an indicator of individual care and hygiene, or results from eating garlic, onion, spicy foods, curry, or drinking alcohol; however, in some instances it can be pathologic. It is a well-known clinical fact that many diseases (both of internal and cutaneous origin), several syndromes, and some intoxications cause characteristic, peculiar, and identifiable odors. Their identification can provide diagnostic clues, guide the laboratory evaluation, and help in the choice of immediate and appropriate therapy. Thus, olfactory evaluation can be an important part of clinical examination and olfactory diagnosis is still valid in recognizing certain diseases. This report reviews the physiological and pathologic body odors and the importance of olfactory diagnosis in dermatology.Öğe A case of Lupus vulgaris with unusual location(Japanese Dermatolgical Assoc, 2003) Senol, M; Ozcan, A; Mizrak, B; Turgut, AC; Karaca, S; Kocer, HTuberculosis (TB) is one of the oldest diseases of our planet; today, it still is a serious medicosocial problem in both developing and developed countries. Cutaneous tuberculosis is part of the small percentage of extrapulmonary forms of the disease and has considerable morphological variability. It is often confused with various cutaneous disorders and some other granulomatous processes of the skin. Here, we present a case of long-standing and atypically-located lupus vulgaris in an old man. The patient was successfully treated with triple antituberculous therapy.Öğe A case of sporotrichosis treated with itraconazole(Taylor & Francis Ltd, 2003) Ozcan, A; Senol, M; Karaca, S; Sener, S; Polat, M; Ozerol, IHLymphocutaneous sporotrichosis is caused by Sporothrix schenckii, a dimorphic fungus commonly existing on decaying plants and in the soil. The fungus has a worldwide distribution but is more prevalent in temperate and tropical climates. Infection may result from traumatic inoculation of contaminated material such as soil, hay, moss, plant debris, splinters, thorns and barbs. Inoculation is also possible through some animal scratches and bites. We describe a typical case of lymphocutaneous sporotrichosis, which was confirmed by clinical, histological and microbiological features. The patient was successfully treated with 400 mg daily systemic itraconazole for 4 months.Öğe A detailed method for isolation and purification of human cutaneous mast cells(Elsevier Ireland Ltd, 2005) Senol, M; Ozerol, IH; Patel, AV; Skoner, DP[Abstract Not Available]Öğe Disseminated lupus vulgaris and papulonecrotic tuberculid: Case report(Blackwell Science Inc, 2000) Senol, M; Ozcan, A; Aydin, A; Karincaoglu, Y; Sasmaz, S; Sener, SThe incidence of tuberculosis and extrapulmonary forms of this disease is increasing all over the world. Lupus vulgaris is the most prevalent form of cutaneous tuberculosis in Europe and the Middle East, Papulonecrotic tuberculid, the most common form of hyperergic response to mycobacteria or their fragments, is uncommon in children. We report lupus vulgaris with papulonecrotic tuberculid in a 12-year-old girl who had a 3-year history of slowly growing plaques on her trunk, extremities, and the tip of her nose and papuloulcerative lesions over her entire body. A skin biopsy specimen showed minimally caseating granulomatous inflammation, Staining for acid-fast bacilli was negative in both plaques and papules. Polymerase chain reaction identified Mycobacterium tuberculosis DNA in the patient's sputum, gastric fluid, and plaques and was negative in the papules. She was started on antituberculous therapy with four drugs and her lesions responded rapidly.Öğe Doppler waveforms and blood flow parameters of the superior and inferior mesenteric arteries in patients having Behcet disease with and without gastrointestinal symptoms -: Preliminary data(Amer Inst Ultrasound Medicine, 2003) Sigirci, A; Senol, M; Aydin, E; Kutlu, R; Alkan, A; Altinok, MT; Yologlu, SObjective. To evaluate hemodynamic changes in mesenteric arteries in patients with Behcet disease with and without gastrointestinal symptoms. Methods. Doppler sonography of mesenteric arteries was performed in 25 symptomatic and 15 asymptomatic patients having Behcet disease and in 25 healthy control subjects. The peak systolic, minimal, and mean velocities, resistive and pulsatility indexes, inner diameter, cross-sectional area, and blood flow volume of mesenteric arteries were evaluated. The results were compared between patient groups and controls. Results. The mesenteric artery flow was significantly greater in patients in the symptomatic group than in those in the asymptomatic group or in controls. In the superior mesenteric artery, mean velocity and mean blood flow volume (0.35+/-0.18 m/s and 711+/-404 mL/min, respectively; P<.0001) in the symptomatic group were significantly higher than in the asymptomatic group (0.16±0.07 m/s and 305±168 mL/min, respectively) or in controls (0.15±0.07 m/s and 290±123 mL/min, respectively). The mean peak systolic velocity (1.23±0.47 m/s; P<.005) in the symptomatic group was significantly higher than in controls (0.93+/-0.23 m/s). In the inferior mesenteric artery, mean velocity and mean blood flow volume (0.25+/-0.10 m/s and 139+/-79 mL/min) in the symptomatic group were significantly higher than in the asymptomatic group (0.16+/-0.07 m/s; P<.006; and 78±26 mL/min; P<.007) or in controls (0.17+/-0.07 m/s; P<.0031; 83±48 mL/min; P<.004). Conclusions. In this study, symptomatic patients with gastrointestinal Behcet disease were associated with a significant increase in mesenteric artery flow that could be evaluated easily on spectral patterns of arteries during Doppler sonography. The Doppler sonographic findings also revealed that intestinal involvement in patients with Behcet disease without gastrointestinal symptoms is not significantly different from that of healthy controls.Öğe Embolia cutis medicamentosa (Nicolau syndrome) two cases due to different drugs in distinct age groups(Adis Int Ltd, 2005) Ozcan, A; Senol, M; Aydin, EN; Aki, T[Abstract Not Available]Öğe False-positive reaction between syphilis and hepatitis C infection(Israel Journal Med Sciences, 1997) Sonmez, E; Ozerol, IH; Senol, M; Kizilkaya, N; Sahin, K; Ozbilge, HThere are limited data about false-positive reactions against hepatitis C virus (HCV) in syphilitic patients and false-positive reactions against syphilis in the patients with HCV infection, The aim of this study was to demonstrate the false-positivity of syphilis in patients with HCV infection, the false-positivity of anti-HCV in patients with syphilis and the validity of the serological tests in such patients. Fifty patients with positive anti-HCV, 21 patients with positive VDRL and 50 healthy subjects were studied. Syphilis serology was determined by the Venereal Disease Research Laboratory (VDRL) test and microhemagglutination for T. pallidum (MHA-TP) test. Hepatitis C serology was determined by a second generation ELISA (Ortho Diagnostics) test for HCV antibody, and anti-HCV positive patients were tested for HCV RNA by polymerase chain reaction (PCR). All assays were performed on all subjects. Not only the false-positive VDRL reaction in the patients with HCV infection but also false-positive anti-HCV tests in syphilitic patients have been observed. Four patients with syphilis had positive anti-HCV and negative HCV-RNA, whereas 10% (5 of 50) of patients with hepatitis C infection had positive VDRL and these patients were negative for MHA-TP test, The rates of false-positivity of VDRL and anti-HCV were higher than within the control group (p<0.05). According to these data, positive anti-HCV in syphilitic patients and positive VDRL in chronic hepatitis C may be false-positive results with regard to the reaginic tests, Therefore, therapeutic measures should not be initiated without confirmation with a treponemal test or PCR. VDRL and HCV-ELISA tests may be interacted with IgM or IgG antibodies. This relationship should be investigated in further studies.Öğe Fox-Fordyce disease(European Acad Dermatology & Venereology, 2003) Ozcan, A; Senol, M; Aydin, NE; Karaca, S; Sener, S[Abstract Not Available]Öğe Giant vascular eccrine spiradenoma(Blackwell Science Ltd, 1998) Senol, M; Ozcan, A; Sasmaz, S; Ozen, S; Ciralik, HA 60-year-old man suffering from cardiac insufficiency consulted the Dermatology Department, Inonu University Turgut Ozal Medical Center, because of a bleeding tumor on his right hypochondrium. The tumor had begun as a small nodule approximately 5 years before, and had grown slowly with time. A small, superficial ulcer had appeared on the lesion approximately 6 months previously, and slight bleeding had occasionally occurred. The patient had no pain and no other complaint except bleeding. Dermatologic examination revealed a violaceous, ulcerated, and bleeding tumoral lesion below the mid-portion of the right costochondral line (Fig. 1). The tumor was a non-tender, hemispheric mass, approximately 3-4 cm in size, adherent to the epidermis, but movable on the underlying tissue. An incisional biopsy was performed with diagnoses of dermatofibrosarcoma protuberans and desmoid tumor. Histopathologic examination revealed prominent blood-filled vascular spaces (Fig. 2) and clearly delimited cords, showing two types of cell (Fig. 3). The vascular spaces contained a periodic acid-Schiff (PAS)-positive, granular, eosinophilic material. There was no malignant transformation. The lesion was totally excised and primarily sutured.Öğe Hair, nail, serum, and urine copper levels in users of copper intrauterine devices and interactions between copper and some other trace elements(Dustri-Verlag Dr Karl Feistle, 1997) Akyol, O; Ersan, F; Akcay, F; Altuntas, Y; Senol, M; Sasmaz, S; Yasar, AWe studied copper (Cu) and some other trace element (Fe, Mg, Zn, and Ca) levels which continuously interact with Cu in hair, nail, serum, and urine of copper intrauterine device (IUD) wearers. This study was performed on 3 groups of women. Twenty-two healthy women were studied as control group (group II), the second group included 18 healthy women who had been using IUD for more than 2 years (group III), and third group included 23 healthy women who had been using IUD for less than 2 years (group III). Cu levels in hair were 37.9 +/- 16.3 ppm in control group, 49.3 +/- 20.0 ppm (p < 0.025) in group I, and 64.5 +/- 29.2 ppm (p < 0.0005) in group III. Cu levels in nail were 21.9 +/- 5.35 ppm in control group, 25.96 +/- 9.05 ppm (p < 0.05) in group II, and 37.71 +/- 11.3 ppm (p < 0.0005) in group III. There was a statistically significant difference between group II and III (p < 0.005). Cu levels were 2.51 +/- 1.1 mu g/ml and 0.33 mu g/ml in serum and urine, respectively in control group, and there were no significant differences between the ether groups. Important differences were also found in the levels of the other trace elements among the groups. In the intracorrelation analyses, positive and negative correlations were present among hair, nail, serum, and urine Cu and the other trace element levels of women using IUD. High levels of Cu in hair and nails showed that Cu, which is released from IUD to intrauterine cavity, was absorbed into the bloodstream and deposited into several organs and tissues like hair and nail. However, requirement of quantitative estimation of excess copper accumulation in tissues by periodical analyses of hair and nail samples from the subjects is controversial.Öğe Heparin-induced exfoliative dermatitis in a patient on haemodialysis(Adis International Ltd, 1999) Sevinc, A; Pekdemir, H; Harputluoglu, M; Sari, R; Buyukberber, S; Senol, M[Abstract Not Available]Öğe Human cutaneous mast cells: Current concepts(Mary Ann Liebert, Inc, 1997) Senol, M; Fireman, PSkin mast cells play an important role in cutaneous inflammation, especially immunoglobulin-E (IgE)-mediated early type, complement-mediated, and T cell-mediated delayed type hypersensitivity reactions. They can synthesize and release various preformed and newly formed mediators that are important in the pathobiology of certain diseases such as urticaria, mastocytosis, atopic dermatitis, contact dermatitis, bullous pemphigoid, scleroderma, psoriasis, and parasitic skin infections. They also have important functions in parasite infestations, angiogenesis, and tissue remodeling besides allergy and inflammation. Their origin, morphology, distribution, heterogeneity, function, activation, and mediators are included in the subject. Interactions of mast cells with their microenvironment and the other cells, and their role in some pathobiological situations are briefly outlined. This article will reinforce the reader's knowledge of the recent concepts on human cutaneous mast cells.Öğe Hypomelanosis of Ito with trisomy 13 mosaicism [46, XY, der (13;13) (q10;q10),+13/46,XY](Turkish J Pediatrics, 2002) Yakinci, C; Kutlu, NO; Alp, MN; Senol, M; Durmaz, Y; Budak, TThe term hypomelanosis of Ito (HI) has been used as a diagnosis for individuals with swirly hypopigmentation or depigmentation distributed along the lines of Blaschko. HI should be appropriately evaluated for a possible association with chromosomal or genetic mosaicism or chimerism. We report a six-month-old severely motor and mental retarded boy with these typical cutaneous lesions associated with extracutaneous features, including facial dysmorphism, polydactyly, and inguinal. hernia. The cytogenetic examination of lymphocytes kdemonstrated a mosaicism of 46, XY, der (13;13) (q10;q10), +13/46, XY. This is the first case reported in the literature showing an association between phylloid pigmentary pattern of hypomelanosis of Ito and trisomy 13 mosaicism.Öğe Papular urticaria(Mary Ann Liebert Inc, 1998) Senol, M; Sasmaz, S; Ozerol, IHPapular urticaria, also known as strophulus, strophulus infantum, strophulus pruriginosus, lichen urticatus, flea-bite dermatitis, prurigo acuta simplex, and prurigo chronica multiformis, is a very pruritic and persistent dermatologic disease of childhood. It is primarily seen in children with atopic diathesis and represents a complex hypersensitivity reaction to many kinds of insect bites. The disease is a relatively common diagnosis in dermatology and pediatric clinics. In this article, we briefly outline recent concepts on its etiologic, epidemiological, physiopathological, clinical, histopathological, and diagnostic properties and review the information about its prevention and therapy.Öğe Periorbital solitary-type infantile myofibromatosis(Slack Inc, 1997) Bayramlar, H; Hepsen, IF; Sarac, K; Hasanoglu, A; Tecimer, T; Ozgen, U; Senol, M[Abstract Not Available]Öğe Pityriasis rosea-like eruption due to lithium(Adis International Ltd, 2004) Senol, M; Ozcan, A; Ozcan, EM; Aydin, EN[Abstract Not Available]Öğe The risk of coronary heart disease in men with androgenetic alopecia(Elsevier Science Bv, 1999) Sasmaz, S; Senol, M; Ozcan, A; Dogan, G; Tuncer, C; Akyol, O; Sener, SBackground The meaningful association of androgenetic alopecia and coronary heart disease has been well documented, but few studies have focused on the importance of lipid parameters, such as total cholesterol, triglycerides, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, lipoprotein (a), apolipoprotein A1 and apolipoprotein B in patients with androgenetic alopecia. Objective The aim of this study is to investigate the relation between androgenetic alopecia and coronary heart disease and to determine the significance of certain lipid parameters on this relationship. Subjects Forty-one men with vertex type androgenetic alopecia (study group) and 36 men, age-matched, with normal hair status (control group) were the subjects of this study. Results We found significant differences in serum lipoprotein (a) and triglyceride levels between the study and control groups (P < 0,05). Forty-seven percent of patients and 30% of controls had a lipoprotein (a) level more than 30 mg/dl higher than the level critical for atherosclerotic heart disease. Conclusion Dermatologists should investigate lipid profile, especially lipoprotein (a), of patients with androgenetic alopecia and refer to a cardiologist if necessary. (C) 1999 Elsevier Science B.V. All rights reserved.Öğe Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis(European Acad Dermatology & Venereology, 2002) Piskin, S; Sayan, C; Durukan, N; Senol, MBackground The exact aetiology of recurrent aphthous stomatitis (RAS) is still unknown, but different predisposing factors, including iron, vitamin B 12 and folic acid deficiencies, have been proposed. Material and methods Serum iron, ferritin, folic acid and vitamin B12 levels were investigated in 35 patients with RAS and in 26 healthy controls. Results Vitamin B12 levels were found significantly lower in subjects with RAS than in controls. No significant differences were found in other parameters. Conclusion We concluded that vitamin B12 deficiency may be an aetiological factor in recurrent aphthous stomatitis.
