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Öğe Comparison of fluconazole and ketoconazole in the treatment of superficial dermatophyte infections(1996) Dogan G.; Sasmaz S.; Ozcan A.; Senol M.; Yologlu S.Background and design.- In this study, we compared the efficacy of fluconazole and ketoconazole in dermatophytosis. Fifty six patients with superficial dermatophyte infection, were randomly given either once-weekly of oral fluconazole 150 mg, or oral ketoconazole 200 mg/d for four weeks. The efficacy of the treatment was evaluated clinically cure and direct microscopic examination at 30th, 60th and 90th day after cessation of the drug. Side effect profile was decided with patients' complaints and laboratory examination. Results.- At the end of study, 85.71% on the 30th day, 92.86% on the 60th day and 85.71% on the 90th day in the fluconazole group showed mycologic eradication; in the ketoconazole group were found 89.28%, 85.71% and 82.14%, respectively. But there was no statistical difference between the two agents. None of the patients described any subjective side effects and all laboratory examination results were normal. Conclusion.- Finally, fluconazole and ketoconazole were found to be equally effective in superficial dermatophyte infections.Öğe Efficacy of micronized flavonoid fraction in healing of clean and infected wounds(Springer New York, 2001) Hasanoglu A.; Ara C.; Ozen S.; Kali K.; Senol M.; Ertas E.Purified micronized flavonoid fraction, comprising 90% diosmin and 10% hesperidin, is basically used as a phelebotonic and vasculoprotector agent. It also has anti-inflammatory and anti-edematous actions. This study was designed to evaluate the efficacy of micronized flavonoid fraction in clean and infectious wounds. Sixty Guinea pigs were separated into 2 main groups and 6 subgroups. The first three groups had clean wounds and the other three groups had infected wounds contaminated with S. aureus. Then these main groups were separated into 3 subgroups. The first subgroups was treated with 60 mg/kg/day micronized flavonoid fraction per oral, the second ones was treated with topical 60 mg/kg/day micronized flavonoid fraction, and the third ones had no treatment. Infected wounds were obtained by contamining the wounds with S. aureus. There were no significant differences in wound healing between the groups that have clean wounds (p > 0.05). In the groups with infected wounds, orally and topically treated guina pigs had accelerated wound healing compared to the untreated control group (p < 0.05), confirmed with surface area measurements and histopathological evaluation. Healing showed no difference between the groups treated orally and topically. This study showed that oral or topical administration of micronized flavonoid fraction in the infected wounds is beneficial, while it has no significant effect in clean wounds.Öğe Human skin mast cell: Current concepts(1997) Senol M.; Fireman P.Skin mast cells play an important role in cutaneous inflammation, especially IgE-mediated, complement-mediated, and T cell-mediated delayed type hypersensitivity reactions. They can synthesize and release various preformed and newly formed mediators that are important in the pathobiology of certain diseases such as urticaria, mastocytosis, atopic dermatitis, contact dermatitis, bullous pemphigoid, scleroderma, psoriasis, and parasitic skin infections. Reading this article will reinforce the reader's knowledge of the recent concepts on human cutaneous mast cells. Their origin, morphology, distribution, heterogeneity, function, activation, and mediators are included in the subject. Interactions of mast cells with their microenvironment and the other cells, and their role in some pathobiologic situations are briefly outlined.Öğe Syringocystadenoma papilliferum(1997) Ozcan A.; Senol M.; Dogan G.; Aydin A.; Atik E.Syringocystadenoma papilliferum is a rare adnexal benign tumur which commonly develops from apocrine sweat glands. It is mostly seen in women. The majority of the lesions are located on the scalp and neck. They are rarely found on the trunk and the extremities. The lesion is generally found as an asymptomatic solitary plaque. A basal cell epithelioma can rarely arise in this lesion especially when exists with a nevus sebaceus. A 33-year-old woman with a syringocystadenoma papilliferum was presented and the current literature on this issue was reviewed.Öğe The treatment of melasma with hydroquinone and hydroquinone, retinoic acid and corticosteroid combination(1995) Senol M.; Ozcan A.; Hazneci E.; Dogan G.Background and design. - For the purpose of comparing the efficacy of hydroquinone alone or a combination (with retinoic acid and corticosteroid) in the treatment of melasma, two groups of patients were studied. Results. - Hydroquinone and combination therapy were used for three months in each group (20 patients). There was no significant difference between the efficacy and the side effects of the two therapy schedule. Conclusion. - We concluded that hydroquinone alone is sufficient in the treatment of melasma because of its economic and practical properties.Öğe Tularemia: A Case Transmitted from a Sheep(1999) Senol M.; Özcan A.; Karincaoglu Y.; Aydin A.; Özerol I.H.Tularemia is an arthropod-borne infectious disease caused by Francisella tularensis, a gram-negative microorganism that normally resides in a wide range of wild and domestic animals. The disease is characterized by a sudden onset with high fever, headache, malaise, chills, myalgia, and arthralgia. A short time after exposure, an inflamed and ulcerated lesion rapidly appears at the site of entry. A regional lymphadenopathy follows the cutaneous presentation. Cultures from the lesions or blood generally give negative results. Histopathologic examination reveals either a nonspecific inflammatory infiltrate or an infectious granuloma. The most useful laboratory procedure in the diagnosis of tularemia is serologic tests. Streptomycin, gentamicin, and tetracycline are the drugs of choice in the treatment Quinolones are also effective. Tularemia is fairly rare in Turkey. We present a typical case of ulceroglandular tularemia transmitted from a sheep to a young man.
