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    Asymmetric dimethylarginine level in hyperglycemic gestation
    (Springer, 2011) Sertkaya, Ayse Cikim; Kafkasli, Ayse; Turkcuoglu, Ilgin; Karabulut, Aysun Bay
    We aimed to evaluate plasma asymmetric dimethylarginine (ADMA) concentrations and its relation with insulin sensitivity/resistance indices in pregnant women with different degrees of carbohydrate intolerance. This study included a two step approach; 50 g glucose challenge test (GCT) followed by 100 g oral glucose tolerance test (OGTT) was used for diagnosis of carbohydrate intolerance within 24-28th weeks of gestation. Pregnant women with positive GCT but negative OGTT (AGCT group, n = 30) and gestational diabetics (GDM group, n = 58) were compared to healthy pregnant controls (n = 50). Plasma ADMA concentration and its relationship with glucose and insulin levels and insulin sensitivity/resistance indices (HOMA-IR, QUICKI, ISIOGTT) were evaluated. Both AGCT and GDM groups were found to have similarly higher plasma ADMA levels than control subjects (3.60 +/- 1.21; 4.00 +/- 1.70; 2.65 +/- 0.82 mu mol/l, respectively, P = 0.001). ADMA was significantly but slightly correlated with insulin sensitivity/resistance indices and moderately correlated with 2-h insulin level. The 2-h insulin value of the OGTT was the independent influencing constant for ADMA (R = 0.57, P = 0.0001). In conclusion, plasma asymmetric dimethylarginine level was higher in cases with abnormal glucose challenge test but normal OGTT as well as in gestational diabetics, compared to pregnant women with normal glucose tolerance. The elevated ADMA level in pregnant women with carbohydrate intolerance may possibly be due to elevated insulin level.
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    DNA repair proteins may differentiate papillary thyroid cancer from chronic lymphocytic thyroiditis and nodular colloidal goiter
    (Nature Portfolio, 2021) Evren, Bahri; Yilmaz, Sami; Karadag, Nese; Sertkaya, Ayse Cikim; Topaloglu, Omercan; Kilinc, Faruk
    Malignant thyroid lesions are the most common malignancy of the endocrine glands with increasing rates in the last two decades. Papillary thyroid cancer is the most common thyroid malignancy. In our study, we aimed to quantitatively evaluate the levels of DNA repair proteins MSH2, MLH1, MGMT, which are representative blocks of patients diagnosed with papillary carcinoma, chronic thyroiditis, or colloidal goiter. Total or subtotal thyroidectomy material of 90 patients diagnosed with papillary carcinoma, nodular colloidal goiter, or chronic thyroiditis between 2009 and 2012 were retrospectively evaluated. Tissue samples obtained from paraffin blocks were stained with MGMT, MSH2, MLH1 proteins and their immunohistochemistry was evaluated. Prepared sections were examined qualitatively by an impartial pathologist and a clinician, taking into account the staining method under the trinocular light microscope. Although there was no statistically significant difference in MGMT, MSH2, MLH1, follicular cell positivity, staining intensity, and immunoreactivity values, papillary carcinoma cases showed a higher rate of follicular cell positivity, and this difference was more pronounced between papillary carcinoma and colloidal goiter. In the MSH2 follicular cell positivity evaluation, the difference between chronic thyroiditis and colloidal goiter was significant (p=0.023). The difference between chronic thyroiditis and colloidal goiter was significant in the MSH2 staining intensity evaluation (p=0.001). The difference between chronic thyroiditis and colloidal goiter was significant in MLH1 immunoreactivity evaluation (p=0.012). Papillary carcinoma cases were demonstrated by nuclear staining only for MSH2 and MLH1 proteins as opposed to hyperplastic nodules. The higher levels of expression of DNA repair genes in malignant tumors compared to benign tumors are attributed to the functional activation of DNA repair genes. Further studies are needed for DNA repair proteins to be a potential test in the development and progression of thyroid cancer.
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    THE RELATIONSHIP BETWEEN HEIGHT MEASUREMENT AND METABOLIC RISK MARKERS IN OVERWEIGHT AND OBESE WOMEN
    (Istanbul Univ, Faculty Medicine, Publishing Office, 2005) Akkaya, Vakur; Sertkaya, Ayse Cikim; Ozbey, Nese; Orhan, Yusuf
    Objective: The aim of this study was to determine the relationship between height and cardiovascular risk markers in overweight and obese women. Materials and methods: The study group was composed of 3665 overweight or obese women with body mass index varying from 25 to 67 kg/m(2). In order to determine the relationship between body height and various cardiovascular risk markers, ANOVA, unpaired-t test and chi-square tests were performed. Results: Data analyses indicated a significant positive relationship between height and weight and HDL cholesterol and an inverse relationship between height and age, serum total cholesterol, glucose, triglyceride, systolic and diastolic blood pressure. No significant relationship was found between height and uric acid, insulin and HOMA (homeostasis model assessment). Age, weight, body mass index, glucose, cholesterol, triglyceride, systolic and diastolic blood pressures were found to vary between quartiles of stature. The incidence of diabetes mellitus, hypertension, hypercholesterolemia and abdominal obesity also was found to differ significantly between quartiles of stature using ANOVAanalysis. Conclusion: These results support the suggestion that short stature may be relevant to hyperglycemia, hypertension and hypercholesterolemia. Therefore, the measurement of metabolic risk markers could be useful in clinical screening for overweight and obese women of short stature.
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    The relationship between obesity and restless legs syndrome
    (2019) Algul, Fatma Ebru; Sertkaya, Ayse Cikim; Altınayar, Sibel
    Restless legs syndrome (RLS) has been shown to be more common in obese than in non-obese people in many studies. The aim of this study was to investigate passible relationship between obesity and seconder RLS prevalence and severity in the Turkish population. Method: A total of 70 volunteers were included in the study. Of these 44 were obese (BMI?30 kg/m2) and 26 were non obese(BMI <30 kg/m2. The International RLS Study Group (International Restless Legs Study Group, IRLSS) diagnosis criteria were used for the RLS diagnosis and International RLS criteria to determine the severity. 17 subjects had RLS and of these 13 were in the obese group and 4 in the non-obese group. No significant difference was found between obese and non-obese groups in terms of RLS prevalence (p:0.165) and RLS severity (p:0.918). Our study on a small sample from the Turkish population showed no significant relationship between obesity and RLS presence and severity. The reason may be the small numbers of obese and control group subjects in our study.