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    Effect of hyperbaric oxygen on hyperglycemia-induced cochlear damage: An experimental study
    (2019) Yiğider, Ayşe Pelin; Gül, Mehmet; Körpınar, Şefika; Kaplan, Mehmet Ali; Server, Ela; Yiğit, Özgür; Daştan, Sevgi; Toklu, Akın Savaş
    Abstract: Objectives: This study aims to investigate whether hyperglycemiainducedcochlear damage can be treated with hyperbaric oxygentherapy (HBOT) in rats with diabetes mellitus using distortionproduct otoacoustic emission (DPOAE) and histopathological analysis.Materials and Methods: The study included 18 male albinoSprague Dawley rats (weighing ?350 g, at least two months ofage). Animals were divided into three groups as the control group(group 1), streptozocin (STZ)-induced diabetes group (group 2),and STZ-induced diabetes+HBOT group (group 3). Distortionproduct otoacoustic emission was used to demonstrate functionalstatus of cochlea and applied at the beginning and at the end of theeighth week. Group 3 was treated with HBOT for one week at sixthweek. By the end of the eighth week, all animals were decapitated.Histological evaluation was performed under light microscopy.Results: All animals in groups 2 and 3 had fasting blood glucose levels>250 mg/dL. There was no difference in terms of signal-to-noise ratiovalues between groups at the end of the study except for 2 kHz, whichwas lower in groups 2 and 3. Histological evaluation showed thatdegenerations including hydropic degeneration, loss of supportingand hair cells, basilar membrane deformation, and fibrinoid materialin deposition in the scala media were higher in group 2 than group 3.Conclusion: In our study, HBOT ameliorated diabetes-inducedcochlear damage histologically. In light of our findings, we believethat the management of hearing loss in diabetics may evolvedramatically if the proper algorithm is formed.