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    Effects of papaverine on healing of colonic anastomosis in rats
    (Springer Wien, 2017) Basceken, Salim Ilksen; Sevim, Yusuf; Akyol, Cihangir; Cicek, Egemen; Aydin, Ferit; Kocaay, Akin Firat; Pasaoglu, Ozge Tugce
    Background Anastomotic leak is the most devastating complication after colorectal surgery, and the blood supply is a very important factor in anastomotic healing. Papaverine is a vasodilatory and antispasmodic agent which has been used in many ischemic conditions because of its potentially protective effects. The aim of this study is to investigate the effects of papaverine on healing colon anastomosis. Methods Forty 8- to 10-week-old female Wistar Albino rats were used in this study. Rats were randomized into 4 groups: control group; ischemia-reperfusion and anastomosis group; ischemia-reperfusion and anastomosis + intraperitoneal one dose papaverine group; and ischemia-reperfusion and anastomosis + intraperitoneal daily (10 days) papaverine group. Anastomotic bursting pressures, the hydroxyproline measurements and macroscopic adhesion gradings were evaluated. Results There was a significant difference between papaverine-administered groups and ischemia-reperfusion and anastomosis group for anastomotic bursting pressures, hydroxyproline measurements and macroscopic adhesion grading (p < 0.05). Conclusion In the rat model, papaverine had a favorable effect on anastomotic healing.
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    Is lesser curvature resection for GIST can be associated with delayed gastric emptying?
    (2020) Donder, Yunus; Baykan, Mehmet; Sevim, Yusuf; Ertan, Tamer; Karagoz Eren, Saliha
    Aim: Patients who performed wedge resection of the lesser curvature of the stomach due to GIST were evaluated for delayed gastric emptying. Material and Methods: Thirty patients who underwent wedge gastric resection for GIST in stomach between 2009-2019 were evaluated retrospectively. In Seven patients it is located in lesser curvature. Results: Fifty-five patients were operated between 2009 and 2019 for GIST.In 7 patients, GIST was found to be located in the lesser curvature of the stomach. Of the 7 patients, 2 (%28) were male and 5 (%72) were female. Laparoscopy was performed in 4 patients and conventional procedure was performed in 3 patients. The average age was 56±10.5 (46-67) years in the conventional procedure group, and 61.5±10.4 (50-73) in the laparoscopic group. Average hospital stay was 4.67±1.5 (3-6) days for conventional procedure and, 2.75±0.9 (2-4) days for the laparoscopic group. Age and length of hospital stay were not different between the two groups (p=0.522 and p=0.094, respectively).All patients had normal radiological findings. Stool discharge was observed on postoperative day 3 at the latest. Conclusion: In conclusion, resection of lesser curvature (with laparoscopic or conventional procedure) GISTs with a tumor free surgical margin staying near to the gastric wall to prevent vagal nerve injury is feasible without gastric emptying problems.