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Öğe Efficiency and side effects of isotretinoin usage in the treatment of acne vulgaris(2008) Çikim A.Ç.; Seyhan M.Background and Design: Although satisfying results with isotretinoin therapy were reported in treatment of severe or moderate but resistant acne vulgaris; the data about this treatment modality in Turkey is insufficient. Therefore we aimed to asses the clinical efficiency of isotretinoin treatment in patients with severe or moderate but resistant acne. Material and Method: Ninety four patients were enrolled into the study. The patients were evaluated for clinical symptoms and biochemical parameters; dosage of isotretinoin treatment; response to treatment and adverse events. Patients received 0,5-1 mg/kg/day isotretinoin for 24-32 weeks, with a 120/mg/kg total cumulative dose. The severity of the facial lesions were graded from 0 (no acne) to 12 (severe acne); and corporal lesions (back and chest) from 0 (no acne) to 8 (severe acne). Results: Although three of the patients (3.2%) failed to continue medication; ninety one patients (96.8%) finale the treatment period with complete recovery. The most common clinical side effect was cheilitis which was seen in all the patients and the most important biochemical side effect was the elevation of serum triglyceride concentrations. Conclusion: Isotretinoin can be concluded as a valuable and rather tolerable choice of treatment in patients with severe or moderate but resistant acne vulgaris.Öğe Mucocutaneous finding in celiac disease(Nova Science Publishers, Inc., 2009) Seyhan M.; Selimo?lu M.A.Celiac disease (CD) once was recognized as a gastrointestinal disease is now known as a disorder with a wide spectrum of signs and symptoms, including dermatological manifestations. A variety of dermatological changes may occur during the course of CD, including desquamating or psoriatic dermatitis, pigmentation, hair and nail abnormalities, as well as the associated specific lesion of dermatitis herpetiformis. Mucocutaneous conditions associated with CD may be classified into two main etiological groups: (1) Autoimmune or immunologically mediated conditions; (2) conditions that result from the complications of malabsorption. However at present the data are not homogeneous and most of the evidence for the association between CD and skin disorders is based on individual cases, making it difficult to draw definitive conclusions on this topic. Sometimes cutaneous symptoms may be the only symptoms of CD, thus dermatologists should recognize the most common dermal and other manifestations of CD, so as to initiate appropriate screening investigations where indicated. In that chapter dermatological disorders associated with CD are discussed. © 2009 Nova Science Publishers, Inc.Öğe Psychiatric morbidity in dermatology patients: Frequency and results of consultations(Medknow Publications and Media Pvt. Ltd, 2006) Seyhan M.; Aki T.; Karincaoglu Y.; Ozcan H.BACKGROUND: Dermatological patients quite commonly depict psychiatric morbidity. PURPOSES: To study the psychiatric morbidity among skin patients of our clinic. METHODS: In the present study, the patients who were treated in the Dermatology Clinic of Inonu University Medical Faculty were evaluated retrospectively. The age, gender, marital status, habits, dermatological and systemic diseases, previously used drugs, current therapy and psychiatric diagnosis of each patient were recorded. FINDINGS: Of 636 patients involved in the study, 15.3% had psychopathological problems, which were depression (32.0%), adjustment difficulty (15.5%), anxiety (13.4%), psychosomatic disorders (10.3%), obsessive-compulsive disorder and conversion (5.1%), dysthymic disorder (4.1%), attention deficit and hyperactivity disorder (2.1%), panic attack (1.0%), premenstrual syndrome, schizophrenia, somatization disorder, insomnia, alcohol dependency, bipolar affective disorder, mental retardation, agoraphobia, social phobia and dementia. The dermatological diseases defined for the patients with psychopathology diagnosis were chronic urticaria (25.8%); psoriasis (15.5%); alopecia areata, totalis and iniversalis (11.3%); acute urticaria, neurodermatitis and Behcet's disease (5.1%); atopic dermatitis and drug eruptions (4.1%); pemphigus (3.1%); angioedema, contact dermatitis and generalized pruritus (2.1%); folliculitis and the others (1.0%). CONCLUSIONS: Psychiatric morbidity has an affect on the course of dermatological diseases. When required, psychiatric consultation should be sought by dermatology clinics and patients should be followed with the cooperation of dermatologists and psychiatrists. LIMITATION: The indoor-based study had not included any control group and any domicillary patient.Öğe An unusual complication of erythema multiforme and its treatment.(2005) Karincaoglu Y.; Coskun B.K.; Seyhan M.[No abstract available]
